Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol

Nastiti, Christofori Maria Ratna Rini; Ponto, Thellie; Mohammed, Yousuf; Roberts, Michael S.; Benson, Heather A. E.

doi:10.3390/pharmaceutics12020108

Cited by 41 publications

(40 citation statements)

References 48 publications

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“…However, one can see that thanks to coumarin encapsulation in the nanoemulsion, the latter penetrates the skin (examined 1 h after application), stopping at the dermis border ( Figure 5 C,D). Similar results were obtained by Sarheed et al [ 59 ], Yousef et al [ 36 ] and Nastiti et al [ 60 ], whereby the encapsulation of loratadine, curcumin and resveratrol, respectively, in a nanoemulsion enhanced the permeability of these compounds through the skin.…”

Section: Resultssupporting

confidence: 88%

Nanoemulsion Stabilized by Safe Surfactin from Bacillus subtilis as a Multifunctional, Custom-Designed Smart Delivery System

et al. 2020

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The developing field of bio-nanotechnology aims to advance colloidal research via the introduction of multifunctional nanoparticles to augment the dermal effectiveness of active substances. Self-emulsifying drug delivery systems (SEDDS)—isotropic mixtures of oils, surfactants, solvents and co-solvents or surfactants—are attracting interest in the cosmeceutical field. As part of this study, SEDDS systems containing vitamin C or vitamin E and curcumin were developed, whereby the bioavailability of the active compounds increased by enhancing their permeability to deeper layers of the skin. A composition consisting of 50% surfactin from Bacillus subtilis, 30% Transcutol and 20% oil phase was designed to encapsulate the active substances, i.e., vitamin C or vitamin E and curcumin, contained in the oil phase. The developed carriers were characterized by average particle sizes of 69–183 nm. The formulations with the vitamins were found to be physically and chemically stable for 6 months. Transdermal tests were carried out, showing that the carriers enable the transport of active substances deep into the skin, stopping at the dermis border. The formulations with vitamin C and vitamin E reduced the discoloration, the vascular lesions, and the depth of the wrinkles on the tested skin, which can be useful in cosmetics in the treatment of problem skin, including capillary and sensitive skin.

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Section: Resultssupporting

confidence: 88%

Nanoemulsion Stabilized by Safe Surfactin from Bacillus subtilis as a Multifunctional, Custom-Designed Smart Delivery System

et al. 2020

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“…Such high doses result in adverse effects (e.g., diarrhea, nausea, and abdominal pain with >1 g/day) [402]. As the poor bioavailability limits the RSV activity, there are various approaches for overwhelming the bioavailability, including co-delivery with piperine prodrug [403], micronized powders [403], and nanoplatform delivery [404][405][406][407]. Application of nanomedicine can improve the stability and bioavailability, and minimize side effects of RSV, which is making RSV a prospective candidate for treating many diseases, including cancers.…”

Section: Resveratrolmentioning

confidence: 99%

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

AbouAitah

Łojkowski

2021

Pharmaceutics

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Natural prodrugs derived from different natural origins (e.g., medicinal plants, microbes, animals) have a long history in traditional medicine. They exhibit a broad range of pharmacological activities, including anticancer effects in vitro and in vivo. They have potential as safe, cost-effective treatments with few side effects, but are lacking in solubility, bioavailability, specific targeting and have short half-lives. These are barriers to clinical application. Nanomedicine has the potential to offer solutions to circumvent these limitations and allow the use of natural pro-drugs in cancer therapy. Mesoporous silica nanoparticles (MSNs) of various morphology have attracted considerable attention in the search for targeted drug delivery systems. MSNs are characterized by chemical stability, easy synthesis and functionalization, large surface area, tunable pore sizes and volumes, good biocompatibility, controlled drug release under different conditions, and high drug-loading capacity, enabling multifunctional purposes. In vivo pre-clinical evaluations, a significant majority of results indicate the safety profile of MSNs if they are synthesized in an optimized way. Here, we present an overview of synthesis methods, possible surface functionalization, cellular uptake, biodistribution, toxicity, loading strategies, delivery designs with controlled release, and cancer targeting and discuss the future of anticancer nanotechnology-based natural prodrug delivery systems.

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“…Recently, various approaches have been proposed to improve RSV biological activities after systemic and topical administration; these strategies include RSV incorporation into different types of nanocarriers and synthesis of prodrugs or RSV derivatives with improved chemical–physical characteristics compared to the parent drug [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. In particular, several studies suggest the feasibility of improving RSV effectiveness by synthesizing derivatives in which molecules that might exert a synergic effect are linked to RSV (i.e., RSV hybrids and codrugs) [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antioxidant and Anti-Glycation Activity of Resveratrol and Its Novel Triester with Trolox

et al. 2020

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Resveratrol (RSV) is well known for its many beneficial activities, but its unfavorable physicochemical properties impair its effectiveness after systemic and topical administration; thus, several strategies have been investigated to improve RSV efficacy. With this aim, in this work, we synthesized a novel RSV triester with trolox, an analogue of vitamin E with strong antioxidant activity. The new RSV derivative (RSVTR) was assayed in vitro to evaluate its antioxidant and anti-glycation activity compared to RSV. RSVTR chemical stability was assessed at pH 2.0, 6.8, and 7.2 and different storage temperatures (5 °C, 22 °C, and 37 °C). An influence of pH stronger than that of temperature on RSVTR half-life values was pointed out, and RSVTR greatest stability was observed at pH 7.2 and 5 °C. RSVTR showed a lower antioxidant ability compared to RSV (determined by the oxygen radical absorbance capacity assay) while its anti-glycation activity (evaluated using the Maillard reaction) was significantly greater than that of RSV. The improved ability to inhibit the glycation process was attributed to a better interaction of RSVTR with albumin owing to its increased topological polar surface area value and H-bond acceptor number compared to RSV. Therefore, RSVTR could be regarded as a promising anti-glycation agent worthy of further investigations.

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Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol

Cited by 41 publications

References 48 publications

Nanoemulsion Stabilized by Safe Surfactin from Bacillus subtilis as a Multifunctional, Custom-Designed Smart Delivery System

Nanoemulsion Stabilized by Safe Surfactin from Bacillus subtilis as a Multifunctional, Custom-Designed Smart Delivery System

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

In Vitro Antioxidant and Anti-Glycation Activity of Resveratrol and Its Novel Triester with Trolox

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