Novel natural compounds from endophytic fungi with anticancer activity

Li, Shoujie; Zhang, Xuan; Wang, Xianghua; Zhao, Changqi

doi:10.1016/j.ejmech.2018.07.015

Cited by 102 publications

(57 citation statements)

References 131 publications

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“…[24,25] Dihydroaltersolanol C and acetylalterporriol E (anthraquinones) Strong cytotoxicity against the murine lymphoma cell line L5178Y. [26] Alterporriol T Inhibition of a-glucosidase [26] Nigbeauvin A and B (azaphilones)…”

Section: -Dehydroaltersolanol a (Anthraquinone)mentioning

confidence: 99%

Beyond Enzyme Production: Solid State Fermentation (SSF) as an Alternative to Produce Antioxidant Polysaccharides

Gutiérrez-Uribe¹,

Verduzco-Oliva²

2019

Preprint

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Solid state fermentation (SSF) is considered more sustainable than traditional fermentation because it uses low amounts of water and transforms agro-industrial residues into value added products. Enzymes, biofuels, nanoparticles and bioactive compounds can be obtained from SSF. The key factor in SSF processes is the choice of microorganisms and their substrates. Many fungal species can be used and are mainly used due their lower requirements of water, O2 and light. Residues rich in soluble and insoluble fiber are utilized by lignocellulolytic fungi because they have the enzymes that break fiber hard structure (lignases, celullases or hemicelullases). During the hydrolysis of lignin, some phenolic compounds are released but fungi also synthetize compounds such as mycophenolic acid, dicerandrol C, phenylacetates, anthraquinones, benzofurans and alkenyl phenols that have health beneficial effects such as antitumoral, antimicrobial, antioxidant and antiviral activities. Another important group of compounds synthetized by fungi during fermentation are polysaccharides that also have important health promoting properties. Fungal biofermentation has also proved to be a process which can release high contents of phenolics and it also increases the bioactivity of these compounds.

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Section: -Dehydroaltersolanol a (Anthraquinone)mentioning

confidence: 99%

Beyond Enzyme Production: Solid State Fermentation (SSF) as an Alternative to Produce Antioxidant Polysaccharides

Gutiérrez-Uribe¹,

Verduzco-Oliva²

2019

Preprint

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“…Among these microorganisms that produce active metabolites, the endophytes that are fungi or bacteria that reside within plant tissues without causing apparent damage (Li et al, 2018) stand out. These are sources of secondary metabolites with many biological activities (Yan et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Chromatography and bioautography of endophytic fungi extracts of Uncaria tomentosa (Willd.) DC with antibacterial activity

Gonã‡Alves¹,

ARAÃšJO²,

Brasil³

et al. 2019

J. Med. Plants Res.

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Endophytic fungi of different species have already proved their efficacy against a range of pathogenic bacteria. However, the separation of the compounds contained in these extracts that actually have an effective activity is not a constant, but it is essential for the scientific knowledge to formulate a new medication. Thus, this study aimed to separate compounds from two endophytic fungi extracts of Uncaria tomentosa with positive results against Gram-positive and Gram-negative bacteria. The separation was carried out by thin-layer chromatography and bioautography. For this, it was necessary to produce fungal extracts from the endophytes Colletotrichum (23916) and Fusarium (23952), which were separated from the liquid state by filtration. The remaining filtrate was divided into ethyl acetate and then concentrated in a rotary evaporator at 40°C. Antimicrobial activity was evaluated and the Minimum Inhibitory Concentration (MIC) was determined with the following test microorganisms: Escherichia coli, Enterecoccus faecalis, Klebsiella pneumoniae and Staphylococcus aureus. Subsequently, it was carried out the thin layer chromatography (TLC) of the extracts using hexane, ethyl acetate/hexane, ethyl acetate and acetate/methanol. The reading was performed in 312 nm UV light, and right after the chromatography, the bioautography was carried out. The following Rf values were obtained: 0.30 for K. pneumoniae and 0.35 for E. coli, in ethyl acetate, for the extract 23952, and 0.81 for K. pneumoniae and 0.41 for S. aureus, in styrene acetate, for the extract 23916, confirming different compounds by bioautography. Therefore, it was concluded that several compounds present in the extracts tested have antibacterial activity.

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“…Os fungos endofíticos, existentes há pelo menos 400 milhões de anos, são considerados microrganismos simbioticamente associados a tecidos internos de plantas, como folhas, caules, casca, raízes, frutos, flores e sementes (LI et al, 2018;TOGHUEO et al, 2017).…”

Section: Fungos Endofíticosunclassified

“…Durante essa associação, a planta fornece nutrição e refúgio aos fungos. Em contrapartida, os mesmos promovem o controle de pragas, a tolerância a seca, a decomposição foliar, auxiliam no fluxo de nutrientes, pH e umidade e fornecem alguns metabólitos secundários importantes para o crescimento de plantas, caracterizando, assim, essa relação como uma simbiose de mutualismo (LI et al, 2018;MANGANYI et al, 2018;YANG et al, 2018;FERNANDES et al, 2015).…”

Section: Fungos Endofíticosunclassified

“…Porcentagem de fungos endofíticos isolados de cada filo de 2014 a 2017 Fonte: Autor "adaptado de"Li et al, 2018 Embora a diversidade de fungos endofíticos seja muito ampla, muitas espécies ainda são desconhecidas e, dentre as mais estudadas atualmente, podem serdestacadas as espécies Beauveria basiana, Metarhizium anisopliae, Isaria farinosa, Cladosporium spp., Fusarium oxysporum, Clonostachys rosea, Hypocrea lixii, Acremonium spp., Lecanicillium lecanii, Gibberella moniliformis, Aermonas hydrophilic, Sphingoonas capsulate, Halobacterium halobium, Myxococcus xanthus, Phomopsis sp., Fusarium tricinctum, Xylaria plebeja, Xylaria sp., Dothideomycete sp., Trichoderma asperellum, encontradas em associação à diversas plantas diferentes (Tabela 10) (BAMISILE et al, 2018; RUSSO et al, 2018; DEZAM et al, 2017; GREENFIELD et al, 2016; ZEILINGER, MARTÍN, GARCÍA-ESTRADA, 2015). Alguns fungos endofíticos associados a diferentes plantas Planta hospedeira Fungos endofíticos encontrados Milho Beauveria bassiana, Clonostachys rosea e, Metarhizium sp.…”

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Obtenção de extratos enzimáticos enriquecidos em proteases a partir de fungos associados a caules e folhas de mandioca visando a digestão do glúten

Garcia¹

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Novel natural compounds from endophytic fungi with anticancer activity

Cited by 102 publications

References 131 publications

Beyond Enzyme Production: Solid State Fermentation (SSF) as an Alternative to Produce Antioxidant Polysaccharides

Beyond Enzyme Production: Solid State Fermentation (SSF) as an Alternative to Produce Antioxidant Polysaccharides

Chromatography and bioautography of endophytic fungi extracts of Uncaria tomentosa (Willd.) DC with antibacterial activity

Obtenção de extratos enzimáticos enriquecidos em proteases a partir de fungos associados a caules e folhas de mandioca visando a digestão do glúten

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