Novel neomycin sulfate-loaded hydrogel dressing with enhanced physical dressing properties and wound-curing effect

Choi, Jong Seo; Kim, Dong Wuk; Kim, Jong Oh; Yong, Chul Soon; Cho, Kwan Hyung; Youn, Yu Seok; Jin, Sung Giu; Choi, Hyun Seok

doi:10.3109/10717544.2015.1089958

Cited by 32 publications

(27 citation statements)

References 33 publications

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“…In this preparation, alginate generates the highest silver and asiaticoside release, improves the foam characteristics with an increase in the absorption property and compressive strength, has a comparable antimicrobial effect in the disk diffusion test and shows noncytotoxicity [ 89 ]. Finally, the alginate dressing preserves a moist environment around the wound, recovers the wound tissue to a normal state, while ensuring the disappearance of granulation tissue [ 90 ] and eliminating the possibility of damaging the tissue when the wound is removed [ 91 ].…”

Section: Applications Of Alginate In the Medical Fieldmentioning

confidence: 99%

Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders

et al. 2020

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Initially used extensively as an additive and ingredient in the food industry, alginate has become an important compound for a wide range of industries and applications, such as the medical, pharmaceutical and cosmetics sectors. In the food industry, alginate has been used to coat fruits and vegetables, as a microbial and viral protection product, and as a gelling, thickening, stabilizing or emulsifying agent. Its biocompatibility, biodegradability, nontoxicity and the possibility of it being used in quantum satis doses prompted scientists to explore new properties for alginate usage. Thus, the use of alginate has been expanded so as to be directed towards the pharmaceutical and biomedical industries, where studies have shown that it can be used successfully as biomaterial for wound, hydrogel, and aerogel dressings, among others. Furthermore, the ability to encapsulate natural substances has led to the possibility of using alginate as a drug coating and drug delivery agent, including the encapsulation of probiotics. This is important considering the fact that, until recently, encapsulation and coating agents used in the pharmaceutical industry were limited to the use of lactose, a potentially allergenic agent or gelatin. Obtained at a relatively low cost from marine brown algae, this hydrocolloid can also be used as a potential tool in the management of diabetes, not only as an insulin delivery agent but also due to its ability to improve insulin resistance, attenuate chronic inflammation and decrease oxidative stress. In addition, alginate has been recognized as a potential weight loss treatment, as alginate supplementation has been used as an adjunct treatment to energy restriction, to enhance satiety and improve weight loss in obese individuals. Thus, alginate holds the promise of an effective product used in the food industry as well as in the management of metabolic disorders such as diabetes and obesity. This review highlights recent research advances on the characteristics of alginate and brings to the forefront the beneficial aspects of using alginate, from the food industry to the biomedical field.

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Section: Applications Of Alginate In the Medical Fieldmentioning

confidence: 99%

Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders

et al. 2020

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“…These gels have tissue-like elasticity, toughness and are non-toxic [9] . Blended PVA gels incorporating several additives, such as L. bulgaricus extract [10] and neomycin sulfate [11] , have been studied in the literature with respect to antibacterial and healing properties.…”

Section: Introductionmentioning

confidence: 99%

Layered cryogels laden with Brazilian honey intended for wound care

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Pereira

et al. 2020

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“…aeruginosa infections [33]. Neomycin sulfate-loaded polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP), and sodium alginate (SA) dressing enhanced wound healing [34]. In general, antimicrobial biopolymers made from polysaccharides are considered superior to polymers made from synthetic polyesters or polyacrylic acid since these synthetic polymers have a risk of toxicity and a high cost of synthesis [35].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial biopolymer formation from sodium alginate and algae extract using aminoglycosides

et al. 2019

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Antimicrobial biopolymers provide a biodegradable, sustainable, safe, and cheap approach to drug delivery and wound dressing to control bacterial infection and improve wound healing respectively. Here, we report a one-step method of making antimicrobial alginate polymer from sodium alginate and aqueous extract of Wakame using antibiotic aminoglycosides. Thin layer chromatography of commercially available sodium alginate and Wakame extract showed similar oligosaccharide profiles. Screening of six aminoglycosides showed that kanamycin disulfate and neomycin sulfate produces the highest amount of biopolymer; however, kanamycin disulfate produces the most malleable and form fitting biopolymer. Image texture analysis of biopolymers showed similar quantification parameters for all the six aminoglycosides. Weight of alginate polymer as a function of aminoglycoside concentration follows a growth model of prion protein, consistent with the aggregating nature of both processes. Slow release of antibiotics and the resulting zone of inhibition against E. coli DH5α were observed by agar well diffusion assay. Inexpensive method of production and slow release of antibiotics will enable diverse applications of antimicrobial alginate biopolymer reported in this paper.

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Novel neomycin sulfate-loaded hydrogel dressing with enhanced physical dressing properties and wound-curing effect

Cited by 32 publications

References 33 publications

Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders

Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders

Layered cryogels laden with Brazilian honey intended for wound care

Antimicrobial biopolymer formation from sodium alginate and algae extract using aminoglycosides

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