Novel PET/CT tracers for targeted imaging of membrane receptors to evaluate cardiomyocyte apoptosis and tissue repair process in a rat model of myocardial infarction

Sun, Ting; Wei, Lijiang; Tian, Hua; Zhan, Wanlin; Ma, Hui; Nie, Dan; Wang, Shilin; Chen, Xin; Tang, Ganghua

doi:10.1007/s10495-021-01681-1

Cited by 3 publications

(1 citation statement)

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“…In conclusion, the group suggests that [ 18 F]-ML-8 appears to be a better marker than [ 18 F]-ML-10 in imaging the process of apoptosis and discriminating necrosis. Two markers [ 18 F]-AlF-NOTA-PEG3-Cinnamycin ([ 18 F]-ANP-Cin) and [ 18 F]-AlF-NOTA-PEG3-β-Glu-RGD2 ([ 18 F]-ANP-RGD2) have been proposed [140]. Sprague Dawley rats were subjected to dynamic imaging establishing a 45 min accumulation peak in the predicted apoptotic zone.…”

Section: Radioisotopic Monitoring Of Cardiomyocytes Apoptosismentioning

confidence: 99%

Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers

Wargocka-Matuszewska

Uhrynowski

Rozwadowska

et al. 2022

IJMS

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Cardiovascular diseases (CVD) is a collective term describing a range of conditions that affect the heart and blood vessels. Due to the varied nature of the disorders, distinguishing between their causes and monitoring their progress is crucial for finding an effective treatment. Molecular imaging enables non-invasive visualisation and quantification of biological pathways, even at the molecular and subcellular levels, what is essential for understanding the causes and development of CVD. Positron emission tomography imaging is so far recognized as the best method for in vivo studies of the CVD related phenomena. The imaging is based on the use of radioisotope-labelled markers, which have been successfully used in both pre-clinical research and clinical studies. Current research on CVD with the use of such radioconjugates constantly increases our knowledge and understanding of the causes, and brings us closer to effective monitoring and treatment. This review outlines recent advances in the use of the so-far available radioisotope markers in the research on cardiovascular diseases in rodent models, points out the problems and provides a perspective for future applications of PET imaging in CVD studies.

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Section: Radioisotopic Monitoring Of Cardiomyocytes Apoptosismentioning

confidence: 99%