Novel pH-sensitive alginate hydrogel delivery system reinforced with gum tragacanth for intestinal targeting of nutraceuticals

Apoorva, Anupam; Rameshbabu, Arun Prabhu; Dasgupta, Swagata; Manchikanti, Padmavati

doi:10.1016/j.ijbiomac.2020.01.027

Cited by 71 publications

(27 citation statements)

References 38 publications

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“…It has been reported that adding GT to polymeric drug delivery systems may improve their physico-mechanical properties and sustained release profile. In this regard, Apoorva et al incorporated GT into pH-sensitive sodium alginate (SA) hydrogels and evaluated its effects on the release profile of the loaded drug, i.e., phenolic compounds extracted from Basella sps [77]. Indeed, they added GT to SA to overcome one of the limitations of pure alginate beads, i.e., the low entrapment efficiency.…”

Section: Gt For Drug Delivery Strategiesmentioning

confidence: 99%

Gum Tragacanth (GT): A Versatile Biocompatible Material beyond Borders

et al. 2021

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The use of naturally occurring materials in biomedicine has been increasingly attracting the researchers’ interest and, in this regard, gum tragacanth (GT) is recently showing great promise as a therapeutic substance in tissue engineering and regenerative medicine. As a polysaccharide, GT can be easily extracted from the stems and branches of various species of Astragalus. This anionic polymer is known to be a biodegradable, non-allergenic, non-toxic, and non-carcinogenic material. The stability against microbial, heat and acid degradation has made GT an attractive material not only in industrial settings (e.g., food packaging) but also in biomedical approaches (e.g., drug delivery). Over time, GT has been shown to be a useful reagent in the formation and stabilization of metal nanoparticles in the context of green chemistry. With the advent of tissue engineering, GT has also been utilized for the fabrication of three-dimensional (3D) scaffolds applied for both hard and soft tissue healing strategies. However, more research is needed for defining GT applicability in the future of biomedical engineering. On this object, the present review aims to provide a state-of-the-art overview of GT in biomedicine and tries to open new horizons in the field based on its inherent characteristics.

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Section: Gt For Drug Delivery Strategiesmentioning

confidence: 99%

Gum Tragacanth (GT): A Versatile Biocompatible Material beyond Borders

et al. 2021

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“…Gels are also easy to manufacture and scale-up and are preferred vaginal drug delivery system among ladies [18,19]. Natural polymers are valuable candidates for mucoadhesive gel formulations due to their proven safety, high biocompatibility, [20,21], ability to conjugate with other polymers [22] and eco-friendliness [23].…”

Section: Introductionmentioning

confidence: 99%

Natural polymers for vaginal mucoadhesive delivery of vinegar, using design of experiment methods

et al. 2022

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Background/Aim. Vinegars are of the main international traditional nutraceuticals which have been used as vaginal health protectant due to vagina pH balance maintenance and antimicrobial properties. Since the main used form of vinegar was liquid, it was difficult for vaginal application with low residence time; in this study a vaginal mucoadhesive gel of vinegar was designed. Methods. Xanthan gum (XG) and tragacanth (TG) were utilized as natural gel forming polymers. The effects of Xanthan gum and tragacanth on mucoadhesion strength and drug release of the gel formulations were optimized using a 3 level (32) factorial design. Several physico-chemical properties of the gel formulations including gel viscosity, spreadability, scanning electron microscopy (SEM) images of hydrogel chains, and release kinetic were also investigated. Results. demonstrated that tragacanth possesses a statistically significant effect on release rate control (p-value=0.0027) while both tragacanth and xanthan gum have significant effect (p value= 0.0001 and 0.0017, respectively) on mucoadhesion property. Conclusion. Design of experiment suggested that formulation F7 with 5% xanthan gum and 1% tragacanth (mucoadhesion = 0.4632 N and release rate = 88.8% in 6 hours) can be considered as the optimum formulation with some modifications.

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“…Even though in recent years the general and scientific interest in nutrition, digestion, and what role they play in our body has increased, there is still much work to be carried out in the field of developing sensors and techniques that are capable of identifying and quantifying the chemical species involved in these processes. Until now, researchers have been monitoring the release of microencapsulated or nanoencapsulated compounds in liquid media in a static process, taking a sample of the medium and measuring it by a spectrophotometer [ 1 , 2 , 3 , 4 , 5 ], proximate analysis (Folin–Ciocalteu method) [ 6 , 7 , 8 , 9 , 10 ], or HPLC [ 11 ], which are static and invasive measurements.…”

Section: Introductionmentioning

confidence: 99%

New Sensor to Measure the Microencapsulated Active Compounds Released in an Aqueous Liquid Media Based in Dielectric Properties in Radiofrequency Range

Tomas-Egea

Fito

Colom

et al. 2021

Sensors

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In recent years, the general and scientific interest in nutrition, digestion, and what role they play in our body has increased, and there is still much work to be carried out in the field of developing sensors and techniques that are capable of identifying and quantifying the chemical species involved in these processes. Iron deficiency is the most common and widespread nutritional disorder that mainly affects the health of children and women. Iron from the diet may be available as heme or organic iron, or as non-heme or inorganic iron. The absorption of non-heme iron requires its solubilization and reduction in the ferric state to ferrous that begins in the gastric acid environment, because iron in the ferric state is very poorly absorbable. There are chemical species with reducing capacity (antioxidants) that also have the ability to reduce iron, such as ascorbic acid. This paper aims to develop a sensor for measuring the release of encapsulated active compounds, in different media, based on dielectric properties measurement in the radio frequency range. An impedance sensor able to measure the release of microencapsulated active compounds was developed. The sensor was tested with calcium alginate beads encapsulating iron ions and ascorbic acid as active compounds. The prediction and measurement potential of this sensor was improved by developing a thermodynamic model that allows obtaining kinetic parameters that will allow suitable encapsulation design for subsequent release.

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Novel pH-sensitive alginate hydrogel delivery system reinforced with gum tragacanth for intestinal targeting of nutraceuticals

Cited by 71 publications

References 38 publications

Gum Tragacanth (GT): A Versatile Biocompatible Material beyond Borders

Gum Tragacanth (GT): A Versatile Biocompatible Material beyond Borders

Natural polymers for vaginal mucoadhesive delivery of vinegar, using design of experiment methods

New Sensor to Measure the Microencapsulated Active Compounds Released in an Aqueous Liquid Media Based in Dielectric Properties in Radiofrequency Range

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