Novel pH sensitive composite hydrogel based on functionalized chitosan/clay for the controlled release of a calcium channel blocker

Abstract

The concept of novel drug delivery systems aims at achieving systematically improved therapeutic success for drugs including those that have limited use because of toxicity, uneven distribution pattern, stability and formulation of difficulties. The paper reveals the potential uses of novel hybrids of oleic acid-g-chitosan and montmorillonite (OA-g-CS/MMT) in controlled drug delivery applications. A calcium channel blocker is a chemical that disrupts the movement of calcium (Ca 2+ ) through calcium channels. The calcium channel blocker used for the present investigation is diltiazem hydrochloride, which forms a class three antianginal drug, and a class IV antiarrhythmic. The drug-loaded novel composites have been prepared by solvent casting and freeze drying of the grafted polymer solution. Drug release was monitored by changing time, percentage of drug loading and pH of the medium. It was observed that the release was much more pronounced in the basic medium than in the acidic medium. The maximum release of drug from OA-g-CS/MMT in both gastric and intestinal fluids was observed within a time period of 12 h.

Nacre-Inspired Tunable Electromagnetic Interference Shielding Sandwich Films with Superior Mechanical and Fire-Resistant Protective Performance

“…As reported, the Ca 2+ cross-linked SA film would greatly enhance the mechanical performance. Besides, when introducing MMT, the geometry of SiO 4 tetrahedrons on the surface of the aluminosilicates contributes to form hydrogen bonds (the Velcro effect), which further improves the interfacial interactions with the CSA by numerous hydrogen bond interaction networks. , Therefore, it remains as a powerful interface interaction within the layers in the CSA-M0.6 film. As for the CSA-M0.6-T20mg sandwich film, the sandwich structure is obvious to observe.…”

Clays as Biomaterials in Controlled Drug Release: A Scientific and Technological Short Review

“…(Table 2) presents the main articles and their peculiarities in the different systems (clay AND drug) used for the purpose of incorporating and releasing the drug in the human organism. Among the evaluated drugs, the classes are: analgesics [4], anticancer [16][17][18] antibiotics, anti-inflammatories [19,20] antibacterials [20][21][22] and vitamins [23][24][25]. The clays, natural or synthetic, that stand out in these studies are: montmorillonite, halloysite, laponite, palygorskite and magnesium phyllosilicates.…”

“…For the authors [4,20,46] all results suggest that it is possible to prepare nanocomposites in which their properties can be controlled by the clay content present in the nanocomposite. Nu-merous studies are reported in the literature regarding the kinetic release study profile [18][19][20][59][60][61]. In the studies ofthe kinetics of in vitro release of 10-hydroxycamptotcin from the nanocomposites were adjusted to the kinetic model of pseudo-second order.…”

Functionalized polymeric silver nanoparticle hybrid network as a dual antimicrobe:Synthesis, characterization, and antibacterial application

“…25 CT is the second most abundant nontoxic cationic polysaccharide, composed of b-(1,4)22-amino-2-deoxy-D-glucose and is widely used in the biomedical field because of its excellent physiochemical properties and its biocompatibility and biodegradability in an aqueous environment. [26][27][28][29] Our research group has already reported the use of a thiolated chitosan/poly(lactic acid) blend incorporated in methionine-modified montmorillonite for the controlled release of amoxicillin (AMO) in the intestinal pH. 30 The hydrophilic nature and higher solubility of CT in an acidic medium prevents its ability to control the release of drug molecules.…”