Novel photothermal therapy using platinum nanoparticles in synergy with near-infrared radiation (NIR) against human breast cancer MCF-7 cell line

Abed, Ali S.; Mohammed, Ahmed Mishaal; Khalaf, Yousif H.

doi:10.1016/j.rechem.2022.100591

Cited by 16 publications

(2 citation statements)

References 42 publications

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“…[ 11,28,58,59 ] We believe that such ability can be of great importance when combined with dual responsiveness of our nanoparticles, as it may allow for a synergistic combination of imaging‐guided drug delivery and photothermal therapy. [ 60,61 ] Further studies are on the way to assess such synergistic therapy with our ternary core‐shell composite nanoparticles in vitro and in vivo.…”

Section: Resultsmentioning

confidence: 99%

Dual Stimuli‐Responsive Ternary Core‐Shell Polystyrene@Pnipam‐Pedot Latexes

Vretik,

Noskov,

Chepurna

et al. 2023

Part & Part Syst Charact

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The ability of stimuli‐responsive materials to respond to external stimuli depends on their intra‐ and intermolecular interactions, which, in turn, are governed by changes in the material composition. Here, the importance of these factors for new heat and light‐sensitive latexes of core‐shell nanoparticles is reported with the polystyrene core, the poly(N‐isopropylacrylamide) (PNIPAM) shell containing doped poly(3,4‐ethylenedioxythiophene) (PEDOT). It is found that hydrogen bonding, C═O─π aromatic, hydrophilic‐hydrophobic interactions in the shell cause conformational changes in PNIPAM similar to those occurring in the PNIPAM coil‐globule transition. Depending on the EDOT:PS@PNIPAM feed ratio and the PEDOT content in PNIPAM shells, these interactions and changes affect nanoparticle sizes and are responsible for shifting the lower critical solution temperature (LCST) of PNIPAM in the shell from 32.1 to 33.9 °C. The core‐shell morphology of nanoparticles is maintained only for latexes with EDOT feed to ≈9 wt.%. At the higher EDOT content, PNIPAM shells are destroyed. Synthesized PS@PNIPAM‐PEDOT latexes demonstrate temperature‐dependent behavior and produce a photothermal effect under NIR irradiation, which allows for a rise of their temperature above LCST. This dual stimuli (heat and light) responsiveness suggests an important possibility for these latexes to be used for drug or diagnostic agent delivery.

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Section: Resultsmentioning

confidence: 99%

Dual Stimuli‐Responsive Ternary Core‐Shell Polystyrene@Pnipam‐Pedot Latexes

Vretik,

Noskov,

Chepurna

et al. 2023

Part & Part Syst Charact

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show abstract

“…The synergy between the NIR and PM-NPs (as therapeutic agents) has been explored by different researchers. Ali et al [95] and Wang et al [96] studies showed an enhanced cytotoxicity on lung (A549), and breast cancer (MCF-7) cell lines when treated with NIR irradiated synthesized Cordia myxa L. leaf extract-PtNPs and Memecylon edule leaf extract-graphene oxide nanoparticles (GO-NPs) respectively. The effects were induced apoptosis in MCF-7/ A549 cells due to photothermal transduction (conversion of low energy into heat) by the respective PtNPs and GO-NPs.…”

Section: Photothermal and Photocatalytic Effectsmentioning

confidence: 99%

Phyto-Metallic Nanoparticles: Biosynthesis, Mechanism, Therapeutics, and Cytotoxicity

Omolaja Akinfenwa,

Abdelfattah Hussein

2024

Toxicity of Nanoparticles - Recent Advances and New Perspectives

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Nanoparticles synthesized from noble metals have wide applications in therapeutics and medicine due to their excellent properties. Properties such as surface plasmon resonance, low toxicity, biocompatibility, and ease of surface modification account for the recent surge in nanoscience and technology. Noble metals such as gold, silver, copper, iron, and platinum with nano size are well-known metallic nanoparticles with increasing applications in nanomedicine. Biomedical applications of these particles especially for diagnosis and targeted drug delivery in living systems require considering the toxicity level. Because of their surface electrons, metal ions in solution affect cellular activities via cell division, apoptosis, DNA replication, homeostasis etc. They influence cell viability through metabolic outputs in both desired and undesired paths which may result in chemical and or biological toxicity to cells. Phyto-metallic nanoparticles biosynthesised from plant extracts are reported with improved functionalities for biomedical applications over those from chemical and physical methods. The synergies from the natural organic properties of the plant and the metallic properties elicit minimal cytotoxicity paving way for their different biomedical applications. This chapter is intended to provide an overview of recent advances and new perspectives in phyto-metallic nanoparticles, their biosynthesis and mechanism, therapeutics, and cytotoxicity to biomedical industries, research centres, and academia.

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Characterization of silver nanoparticles (AgNPs) synthesized using polyphenolic compounds from Phyllanthus emblica L. and their impact on cytotoxicity in human cell lines

Sivalingam,

Pandian

2024

Carbohydrate Polymer Technologies and Applications

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Novel photothermal therapy using platinum nanoparticles in synergy with near-infrared radiation (NIR) against human breast cancer MCF-7 cell line

Cited by 16 publications

References 42 publications

Dual Stimuli‐Responsive Ternary Core‐Shell Polystyrene@Pnipam‐Pedot Latexes

Dual Stimuli‐Responsive Ternary Core‐Shell Polystyrene@Pnipam‐Pedot Latexes

Phyto-Metallic Nanoparticles: Biosynthesis, Mechanism, Therapeutics, and Cytotoxicity

Characterization of silver nanoparticles (AgNPs) synthesized using polyphenolic compounds from Phyllanthus emblica L. and their impact on cytotoxicity in human cell lines

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