Novel Principles and Methods in Bacterial Cell Cycle Physiology: Celebrating the Charles E. Helmstetter Prize in 2022

Norris, Vic; Zaritsky, Arieh

doi:10.3390/life13122260

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A New Prize1

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2024

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“…To remedy the paucity of prizes for work related to the bacterial cell cycle, the Charles E. Helmstetter Prize for Groundbreaking Research in Bacterial Cell Cycle Physiology was inaugurated recently at the EMBO Workshop Bacterial cell biophysics: DNA replication, growth, division, size and shape , which was held in Ein Gedi, Israel (Norris and Zaritsky, 2023 ). It was named in honour of the person widely acknowledged as having provided the theoretical and experimental bases for our current understanding of the bacterial cell cycle.…”

Section: A New Prizementioning

confidence: 99%

Science and prizes

Norris

2024

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Section: A New Prizementioning

confidence: 99%

Science and prizes

Norris

2024

EMBO Rep

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Hunting the Cell Cycle Snark

Norris

2024

Life

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In this very personal hunt for the meaning of the bacterial cell cycle, the snark, I briefly revisit and update some of the mechanisms we and many others have proposed to regulate the bacterial cell cycle. These mechanisms, which include the dynamics of calcium, membranes, hyperstructures, and networks, are based on physical and physico-chemical concepts such as ion condensation, phase transition, crowding, liquid crystal immiscibility, collective vibrational modes, reptation, and water availability. I draw on ideas from subjects such as the ‘prebiotic ecology’ and phenotypic diversity to help with the hunt. Given the fundamental nature of the snark, I would expect that its capture would make sense of other parts of biology. The route, therefore, followed by the hunt has involved trying to answer questions like “why do cells replicate their DNA?”, “why is DNA replication semi-conservative?”, “why is DNA a double helix?”, “why do cells divide?”, “is cell division a spandrel?”, and “how are catabolism and anabolism balanced?”. Here, I propose some relatively unexplored, experimental approaches to testing snark-related hypotheses and, finally, I propose some possibly original ideas about DNA packing, about phase separations, and about computing with populations of virtual bacteria.

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Novel Principles and Methods in Bacterial Cell Cycle Physiology: Celebrating the Charles E. Helmstetter Prize in 2022

Abstract: This Special Issue celebrates the creation of the Charles E [...]

Cited by 2 publications

References 14 publications

Science and prizes

Science and prizes

Hunting the Cell Cycle Snark

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