Novel prognostic value and potential utility of opioid receptor gene methylation in liquid biopsy for oral cavity cancer

Ishikawa, Ryuji; Imai, Atsushi; Mima, Masato; Yamada, Satoshi; Takeuchi, Kouichi; Mochizuki, Daiki; Shinmura, Daichi; Kita, Junya; Nakagawa, Takuya; Kurokawa, Tomoya; Misawa, Yuki; Nakanishi, Hiroshi; Takizawa, Yoshinori; Misawa, Kiyoshi

doi:10.1016/j.currproblcancer.2021.100834

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…Then, the ctDNA methylation levels of these markers were monitored at different time points during follow-up which demonstrated the potential value of these methylated markers to assess the clinical evolution of the disease in oropharyngeal cancer patients who underwent different treatments [88] . Similarly, Ishikawa et al observed significantly higher OPRL1 gene levels in pretreatment samples with respect to post-treatment ctDNA samples, reflecting the potential utility of ctDNA methylation-based detection in the clinical management of oral cancer [87] .…”

Section: Applications Of Cell-free Dna In Head and Neck Cancermentioning

confidence: 88%

“…However, the performance of these biomarkers could be affected by the different methodological design of each study as well as the different preanalytical and postanalytical factors. Thus, the size of study cohort represents one of the most frequent limitations in the investigations [80] , [84] , [86] , [87] , so a further validation in an independent cohort is required to validate the performance of methylation biomarkers. Regarding the patient clinicopathological characteristics, the TNM stage was specified in only three studies [80] , [82] , [84] whereas the HPV status was described in one research [84] .…”

Section: Applications Of Cell-free Dna In Head and Neck Cancermentioning

confidence: 99%

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Liquid biopsies based on cell-free DNA as a potential biomarker in head and neck cancer

Rapado-González,

Rodríguez-Ces,

López-López

et al. 2023

Japanese Dental Science Review

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Section: Applications Of Cell-free Dna In Head and Neck Cancermentioning

confidence: 88%

Section: Applications Of Cell-free Dna In Head and Neck Cancermentioning

confidence: 99%

Liquid biopsies based on cell-free DNA as a potential biomarker in head and neck cancer

Rapado-González,

Rodríguez-Ces,

López-López

et al. 2023

Japanese Dental Science Review

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“…Furthermore, Inamoto et al reported that NR4A2 is a tumor suppressor in human bladder cancer tissues [ 51 ]. Regarding OPRL1, it belongs to the Aγ family of G protein-coupled receptors, which are involved in various diseases, including cancer [ 54 , 55 ]. Bedini et al revealed that OPRL1 acts as a tumor inhibitor in U87 glioblastoma cells by blocking lipopolysaccharide [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Immune Profiles Can Represent the Tumor Immune Microenvironment Related to the Tumor Budding Histology in Uterine Cervical Cancer

Nguyen

Lee

et al. 2022

Genes

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Tumor budding (TB) histology has become a critical biomarker for several solid cancers. Despite the accumulating evidence for the association of TB histology with poor prognosis, the biological characteristics of TB are little known about in the context related to the tumor immune microenvironment (TIME) in uterine cervical cancer (CC). Therefore, this study aimed to identify the transcriptomic immune profiles related to TB status and further provide robust medical evidence for clinical application. In our study, total RNA was extracted and sequenced from 21 CC tissue specimens. As such, 1494 differentially expressed genes (DEGs) between the high- and low-TB groups were identified by DESeq2. After intersecting the list of DEGs and public immune genes, we selected 106 immune-related DEGs. Then, hub genes were obtained using Least Absolute Shrinkage and Selection Operator regression. Finally, the correlation between the hub genes and immune cell types was analyzed and four candidate genes were identified (one upregulated (FCGR3B) and three downregulated (ROBO2, OPRL1, and NR4A2) genes). These gene expression levels were highly accurate in predicting TB status (area under the curve >80%). Interestingly, FCGR3B is a hub gene of several innate immune pathways; its expression significantly differed in the overall survival analysis (p = 0.0016). In conclusion, FCGR3B, ROBO2, OPRL1, and NR4A2 expression can strongly interfere with TB growth and replace TB to stratify CC patients.

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“…Studies have also explored the role of somatic gene mutations and DNA methylation in cfDNA as biomarkers of HNC [113][114][115][116]. A study by Wang et al reported tissue somatic mutations in TP53, PIK3CA, CDKN2A, FBXW7, HRAS, and NRAS and are found in cfDNA obtained from plasma and saliva of HNC patients [117].…”

Section: Circulating Tumor Dna In Head and Neck Cancermentioning

confidence: 99%

Liquid Biopsy in Head and Neck Cancer: Its Present State and Future Role in Africa

Temilola,

Adeola,

Grobbelaar

et al. 2023

Cells

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The rising mortality and morbidity rate of head and neck cancer (HNC) in Africa has been attributed to factors such as the poor state of health infrastructures, genetics, and late presentation resulting in the delayed diagnosis of these tumors. If well harnessed, emerging molecular and omics diagnostic technologies such as liquid biopsy can potentially play a major role in optimizing the management of HNC in Africa. However, to successfully apply liquid biopsy technology in the management of HNC in Africa, factors such as genetic, socioeconomic, environmental, and cultural acceptability of the technology must be given due consideration. This review outlines the role of circulating molecules such as tumor cells, tumor DNA, tumor RNA, proteins, and exosomes, in liquid biopsy technology for the management of HNC with a focus on studies conducted in Africa. The present state and the potential opportunities for the future use of liquid biopsy technology in the effective management of HNC in resource-limited settings such as Africa is further discussed.

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Novel prognostic value and potential utility of opioid receptor gene methylation in liquid biopsy for oral cavity cancer

Cited by 5 publications

References 28 publications

Liquid biopsies based on cell-free DNA as a potential biomarker in head and neck cancer

Liquid biopsies based on cell-free DNA as a potential biomarker in head and neck cancer

Transcriptomic Immune Profiles Can Represent the Tumor Immune Microenvironment Related to the Tumor Budding Histology in Uterine Cervical Cancer

Liquid Biopsy in Head and Neck Cancer: Its Present State and Future Role in Africa

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