Novel Quinolone Derivatives: Synthesis and Antioxidant Activity

Abstract

Novel quinolone derivatives have been designed and readily synthesized according to a simple protocol including O -alkylation and Claisen rearrangement processes. Structures of the synthesized compounds have been confirmed by IR, 1 H and 13 C NMR, and mass spectra. The new products have been tested for their antioxidant activity, and two of those demonstrate high antioxidant activity.

Recent Advances in the Synthesis of Fused‐Cyclic Quinolines

“…The page of the literature is enriched with the glorious achievement of heterocyclo/cyclopenta-fused quinoline such as indoloquinolines, furoquinolines, thioquinolines, and polycyclic quinolines due to the highly biological and pharmacological activities. [32][33][34][35] Due to the existence of polycyclic quinoline backbones in various bioactive natural products, this type of structures has gained extreme popularity in the field of pharmaceutical and synthetic chemistry. [10,[36][37][38] Luotonin A 13 and camptothecin 14 as natural topoisomerases, possessing anticancer activity are examples of pentacyclic quinoline scaffold.…”

“…The page of the literature is enriched with the glorious achievement of heterocyclo/cyclopenta‐fused quinoline such as indoloquinolines, furoquinolines, thioquinolines, and polycyclic quinolines due to the highly biological and pharmacological activities [32–35] …”

Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs – a review

“…Furthermore, functionalized quinoline moieties are highly essential pharmacophoric motifs with undeniable therapeutic propensity owing to their numerous reported biological and pharmacological activities, which include anticancer, 13 antimicrobial, 14 anti-inflammatory, 15 antioxidant, 16 antitubercular, 17 antimalarial, 18 anti-leishmanial, 19 antiprotozoal, 20 anti-HIV, 21 and DNA binding 22 among others. However, the previous review by Sharma and coworkers only highlighted the anti-cancer activities of quinoline derivatives, 2 while the review by Martins and coworkers focused on the quinoline heterocycle as a tool box in nanomedicine.…”