Novel Ratio-Based Fluorescent Probe for Intracellular Cys Detection

Zhou, Xinzhu; Cui, Mengyuan; Jia, Chengli; Yang, Min; Ji, Meiling; Wang, Peng

doi:10.6023/cjoc202003007

Cited by 3 publications

(1 citation statement)

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“…But these methods are unfit for hydrazine detection in biological samples because they need to destruct the cells or tissues. Fluorescent probe has attracted great concern for its selectivity, sensitivity, and good consistency for biology samples [7][8][9][10][11][12]. So far, a great number of fluorescent probes based on pyrazoline [13,14], coumarin [15,16], naphthalimide [17,18], BODIPY [19], benzthiazole [20], flavone [21,22], and carbazole [23] have been exploited for hydrazine detection.…”

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confidence: 99%

A novel ESIPT fluorescent probe derived from 3-hydroxyphthalimide for hydrazine detection in aqueous solution and living cells

Wang

Luo

et al. 2021

Anal Bioanal Chem

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Hydrazine is a highly toxic and flammable liquid that can damage human liver, kidney, and central nervous system. Therefore, it is valuable to seek a quick and sensitive method for hydrazine detection in environmental and biological science. Herein, a new fluorescent probe derived from 3-hydroxyphthalimide was synthesized. This probe can rapidly and selectively detect hydrazine with a low detection limit of 4.3 × 10 −7 M. The recognition principle is based on hydrazine-induced acetyl deprotection and excited-state intramolecular proton transfer (ESIPT) process. Moreover, test paper and fluorescence image experiments showed that this probe had potential to monitor hydrazine in the environment and living cells.

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