2018
DOI: 10.1242/jcs.213595
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Novel role for Grainy head in the regulation of cytoskeletal and junctional dynamics during epithelial repair

Abstract: Tissue repair is critical for the maintenance of epithelial integrity and permeability. Simple epithelial repair relies on a combination of collective cell movements and the action of a contractile actomyosin cable at the wound edge that together promote the fast and efficient closure of tissue discontinuities. The Grainy head family of transcription factors (Grh in flies; GRHL1-GRHL3 in mammals) are essential proteins that have been implicated both in the development and repair of epithelia. However, the gene… Show more

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Cited by 4 publications
(2 citation statements)
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“…Transcription factors belonging to the highly conserved Grainyhead family act as important regulators of epidermal morphogenesis, wound healing, and barrier function [10][11][12][13][14][15][16]. Consistent with this, the three mammalian Grainyhead-like (Grhl) paralogs control the expression of genes important for cell adhesion and extracellular barrier repair.…”
Section: Introductionmentioning
confidence: 76%
“…Transcription factors belonging to the highly conserved Grainyhead family act as important regulators of epidermal morphogenesis, wound healing, and barrier function [10][11][12][13][14][15][16]. Consistent with this, the three mammalian Grainyhead-like (Grhl) paralogs control the expression of genes important for cell adhesion and extracellular barrier repair.…”
Section: Introductionmentioning
confidence: 76%
“…[29] As a member of the GRHL family, GRHL1 plays an important role in regulating embryogenesis, embryonic development, formation of the epidermal barrier and repair of epidermal injury. [30][31][32][33] Furthermore, a great number of research have shown that the GRHL1 acted as a tumor suppressive factor in carcinogenesis, progression and prognosis of various cancer types including liver cancer, skin cancer, neuroblastoma and clear cell renal cell carcinoma. [34] GRHL1 plays a critical role in fate determination of pluripotent cells, which might be relevant to phenotypic plasticity in tumors.…”
Section: Discussionmentioning
confidence: 99%