Novel self-assembling cyclic peptides with reversible supramolecular nanostructures

Ciulla, Maria Gessica; Fontana, Federico; Lorenzi, Roberto; Marchini, Amanda; Campone, Luca; Sadeghi, Ehsan; Палеари, А.; Sattin, Sara; Gelain, Fabrizio

doi:10.1039/d3qm00198a

Cited by 2 publications

(1 citation statement)

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“…The first SAP, Ac-(AEAEAKAK) 2 -CONH 2 , was discovered in the yeast of protein zuotin, in 1993, by Shuguang Zhang [108]. Subsequently, other SAPs were developed: RADA16 [109,110], KLDL12 [111], biotin-based SAPs [112], Fmoc-FFF [53], LKLK12 [25,30], all-L cyclo-LDLK12 and all-L cyclo-FAQLDLK12 [113], D/L cyclo-FF [114], D/L cyclo-LDLD2 [115], branched-SAPs [51], amphiphilic SAPs [116,117], and oligoSAPs (O n (SL) 6 O n ) [118].…”

Section: Self-assembling Peptidesmentioning

confidence: 99%

Recent Advances in the Development of Biomimetic Materials

Ciulla,

Massironi,

Sugni

et al. 2023

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In this review, we focused on recent efforts in the design and development of materials with biomimetic properties. Innovative methods promise to emulate cell microenvironments and tissue functions, but many aspects regarding cellular communication, motility, and responsiveness remain to be explained. We photographed the state-of-the-art advancements in biomimetics, and discussed the complexity of a “bottom-up” artificial construction of living systems, with particular highlights on hydrogels, collagen-based composites, surface modifications, and three-dimensional (3D) bioprinting applications. Fast-paced 3D printing and artificial intelligence, nevertheless, collide with reality: How difficult can it be to build reproducible biomimetic materials at a real scale in line with the complexity of living systems? Nowadays, science is in urgent need of bioengineering technologies for the practical use of bioinspired and biomimetics for medicine and clinics.

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