Novel Self-Healing Hydrogel with Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties Based on Collagen and Chitosan

Ding, Chaoliang; Tian, Mengdie; Ren, Feng; Dang, Yuan; Zhang, Min

doi:10.1021/acsbiomaterials.0c00588

Cited by 102 publications

(89 citation statements)

References 49 publications

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“… Chitosan‐collagen based hydrogels and their different crosslinking pattern reported by Cuicui Ding et al [19] …”

Section: Biopolymer‐based Hydrogelsmentioning

confidence: 93%

“…Moreover, upon excitation OPEs exhibits antibacterial Figure 3. Chitosan-collagen based hydrogels and their different crosslinking pattern reported by Cuicui Ding et al [19] activities against both Gram-negative and Gram-positive bacteria. Hence, for the preparation of antimicrobial DNA hydrogel, they first synthesized DNA hydrogel through the cross-linking between salmon sperm DNA and ethylene glycol diglycidyl ether (EGDGE).…”

Section: Dna Based Antimicrobial Hydrogelmentioning

confidence: 94%

“…Schematic presentation of silver loaded antimicrobial hydrogel reported by Bihua Xia et al [9] prepared a chitosan-collagen based pH-responsive hydrogel and used the same for wound healing (Figure 3). [19]…”

Section: Chitosan-based Antimicrobial Hydrogelmentioning

confidence: 99%

“…prepared a chitosan‐collagen based pH‐responsive hydrogel and used the same for wound healing (Figure 3). [19] …”

Section: Biopolymer‐based Hydrogelsmentioning

confidence: 99%

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Antimicrobial Hydrogels: Promising Soft Biomaterials

Kundu

Payal

2020

ChemistrySelect

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Hydrogel is a three‐dimensional, hydrophilic network of cross‐linked monomer or polymer units. A modified version of the hydrogel which exhibits antimicrobial properties is known as antimicrobial hydrogel. Antimicrobial properties of the antimicrobial hydrogel are due to the inheritance of antimicrobial monomers/polymers or due to the installation by the incorporation of antimicrobial agents such as a metal nanoparticle, metal oxide, antibiotics, and any other synthetic drug molecule. More attention has been taken towards antimicrobial hydrogel as the pharmaceutical and biomedical field facing the problem of drug resistance. Antimicrobial hydrogel provides a suitable alternative for antibiotic drugs and also successful to replace many antibiotic drugs which cause a serious side effect on the human body. Antimicrobial hydrogel targets the cell membrane of the microorganism and destroys them. Due to this unique type of cell lysis mechanism, microbes are rarely able to develop resistance towards antimicrobial hydrogel. The hydrogel is porous, highly flexible, and holds a particular amount of water. These properties impart a moist and living body tissue‐like environment and hence make it a suitable biomaterial to use in biomedical applications. The present article focused on the recent development of bio‐based antimicrobial hydrogels and their applications in drug delivery, wound healing and dressing, tissue engineering, and agriculture.

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“… Chitosan‐collagen based hydrogels and their different crosslinking pattern reported by Cuicui Ding et al [19] …”

Section: Biopolymer‐based Hydrogelsmentioning

confidence: 93%

Section: Dna Based Antimicrobial Hydrogelmentioning

confidence: 94%

Section: Chitosan-based Antimicrobial Hydrogelmentioning

confidence: 99%

“…prepared a chitosan‐collagen based pH‐responsive hydrogel and used the same for wound healing (Figure 3). [19] …”

Section: Biopolymer‐based Hydrogelsmentioning

confidence: 99%

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Antimicrobial Hydrogels: Promising Soft Biomaterials

Kundu

Payal

2020

ChemistrySelect

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“…Therefore, the production of collagen-based dressing is often accompanied by cross-linkers and other materials. 83 Ding et al 84 introduced a method to generate a hydrogel dressing with injectable and rapid recovery capacity. They utilized dibenzaldehyde-modified PEG2000 (DA-PEG) as a cross-linking agent and constructed a collagen–chitosan (COL–CS) scaffold.…”

Section: Polymers Utilized In Hydrogel Wound Dressingsmentioning

confidence: 99%

Recent advances on polymeric hydrogels as wound dressings

Pan

2021

APL Bioengineering

109

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Severe hemorrhage is a leading cause of high mortality in critical situations like disaster, accidents, and warfare. The resulting wounds could induce severe physical and psychological trauma to patients and also bring an immense socio-economic burden. Hence, rapid hemostasis and wound healing techniques have become critical initiatives for life-saving treatment. Although traditional methods relying on bandages and gauzes are effective in controlling hemorrhage, they suffer from several limitations: nonbiodegradability, being susceptible to infection, being unsuitable for the irregular wound, secondary tissue damage, and being almost ineffective for wound healing. Owing to the merits of high porosity, good biocompatibility, tunable physicochemical properties, and being beneficial for wound healing, hydrogels with excellent performance have drawn intensive attention and numerous novel effective hydrogel dressings have been widely developed. In this Review, after introducing some commonly used strategies for the synthesis of hydrogels, the most recent progress on polymer-based hydrogels as wound dressings is discussed. Particularly, their hemostasis, antibacterial, and biodegradation properties are introduced. Finally, challenges and future perspectives about the development of hydrogels for wound dressings are outlined.

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