Novel semisolid SNEDDS based on PEG-30-dipolyhydroxystearate: Development and characterization

Hassan, Tamer H.; Metz, H.; Mäder, Karsten

doi:10.1016/j.ijpharm.2014.10.063

Cited by 14 publications

(2 citation statements)

References 52 publications

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“…Structure of DPHS adapted from Hassan et al: (A) hydrophobic poly(12-hydroxystearic acid) with n = 9 units and (B) hydrophilic polyethylene glycol with m = 30 units, average molecular weight ≥5000 g/mol.…”

Section: Resultsmentioning

confidence: 99%

Reverse Hexosome Dispersions in Alkanes—The Challenge of Inverting Structures

Pirolt¹,

Glatter

Trimmel³

2018

Langmuir

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Monoglycerides form lipophilic liquid-crystalline (LC) phases when mixed with water. The corresponding LC nanostructures coexist with excess water, which is a necessary condition for the formation of internally nanostructured dispersed particles. These nanostructures comprise bicontinuous cubic phases, inverted hexagonal phases, and inverted micellar cubic phases. The dispersed particles are therefore named cubosomes, hexosomes, or micellar cubosomes. Such dispersions are usually stabilized by hydrophilic high-molecular-weight triblock (TB) copolymers. Another way to stabilize such dispersions is by forming the so-called Pickering or Ramsden emulsions using nanoparticles as stabilizers. In this contribution, we explore the possibility of forming and stabilizing inverted or reverse systems, that is, dispersions of hydrophilic LC phases in an excess oil phase like tetradecane. Our aim was to change from oil-in-water emulsions to water-in-oil emulsions, where the water phase is a LC phase in equilibrium with excess oil and where the oil is nonpolar, for example, an alkane. This work consists of three parts: (1) to find a hexagonal hydrophilic LC phase that can not only incorporate a certain amount of tetradecane but can also coexist with excess tetradecane in the case of higher oil concentration, (2) to find a suitable stabilizer-either polymeric or nanoparticle type-that can stabilize the emulsion without destroying the hexagonal LC phase, and finally (3) to check the stability of this reverse hexosome emulsion. We discovered that it is possible to create a hexagonal hydrophilic LC phase with short-chain nonionic surfactants such as polyethylene glycol alkyl ethers or with high-molecular-weight TB copolymers of type A-B-A. Furthermore, it is possible to successfully stabilize the reverse hexosomes with low hydrophilic-lipophilic balance TB copolymers-either synthesized in our laboratory or commercially available ones-as well as with hydrophobized, commercially available silica nanoparticles.

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Section: Resultsmentioning

confidence: 99%

Reverse Hexosome Dispersions in Alkanes—The Challenge of Inverting Structures

Pirolt¹,

Glatter

Trimmel³

2018

Langmuir

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“…Furthermore, the solidification of lipid formulation is required to enhance its flexibility and feasibility for the further development processes e.g . tablet, granule/powder filled to capsule formulation, and a new concept of dry nanoemulsion (89). In addition, the solidification of liquid SNEDDS formulation is attractive and applicable for pharmaceutical industries (10).…”

Section: Introductionmentioning

confidence: 99%

Understanding the effect of lipid formulation loading and ethanol as a diluent on solidification of pitavastatin super-saturable SNEDDS using factorial design approach

et al. 2019

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Solidification of a preconcentrate lipid formulation namely self-nano emulsifying drug delivery system (SNEDDS) is required to achieve feasibility, flexibility, and a new concept of “dry nano-emulsion”. The purpose of this study was to assess the effect of SNEDDS loading and ethanol as a diluent on the solidification of pitavastatin supersaturable SNEDDS (S-SNEDDS). A 22 full factorial design approach with a center point addition as a curvature was implemented to determine the effect of S-SNEDDS loading and ethanol on the physical characteristics, namely flowability, compactibility, and drug release behavior. Vibrational spectra, thermal behavior, and morphology of solid S-SNEDDS formulation were also evaluated. The results indicated that there was no interaction between S-SNEDDS and carrier, based on vibrational spectra. However, thermal behaviors (enthalpy and weight loss) were depending on SNEDDS loading. Thereafter, the ethanol as a diluent of preconcentrated formulation had no effect on the morphology of carrier structure. However, the S-SNEDDS loading altered the structure of carrier owing to either solubilization or abrasion processes. The statistical model suggested that ethanol as diluent reduced the flowability, compactibility, and drug releases. Meanwhile, the liquid SNEDDS loading affected the reducing of flowability and compactibility. Finally, solidification without diluent and 20% lipid formulation load was recommended. In addition, it was very useful because of ease on handling, flexibility for further formulation, and desired characteristics of final solid dosage form.

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Innovative Self Nano‐Emulsifying Drug Delivery Systems for Peptic Ulcer Therapy: A Review

Mujtaba,

Arshad,

Aman

et al. 2024

Part & Part Syst Charact

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Peptic ulcer disease (PUD) adversely affects ≈4 million individuals globally and remains pervasive among 5–10% of the general population. Mucosal lesions prompted by the ulceration lead to the penetration through mucosal layers, ultimately resulting in cavity formation and inflammation. Conventional therapeutic modalities for peptic ulcers have shown unfavorable effects, relapses, and numerous drug interactions. The genesis of gastric ulcers is catalyzed via an imbalanced interplay between environmental lesions, defensive mechanisms, and the restoration of gastric mucosa. Lipid based nanotechnology involved in self‐nanoemulsifying drug delivery system (SNEDDS) is being tremendously involved in opening avenues in innovative pharmaceutical delivery systems in terms of improving solubility and regenerative healing against peptic ulcers. Biological macromolecules can be incorporated into SNEDDS to embellish the drug delivery system on an advanced level. Herein, in this review, the potential of SNEDDS as a viable carrier for administering biomacromolecules for regenerative healing in ulcers is discussed in detail.

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Novel semisolid SNEDDS based on PEG-30-dipolyhydroxystearate: Development and characterization

Cited by 14 publications

References 52 publications

Reverse Hexosome Dispersions in Alkanes—The Challenge of Inverting Structures

Reverse Hexosome Dispersions in Alkanes—The Challenge of Inverting Structures

Understanding the effect of lipid formulation loading and ethanol as a diluent on solidification of pitavastatin super-saturable SNEDDS using factorial design approach

Innovative Self Nano‐Emulsifying Drug Delivery Systems for Peptic Ulcer Therapy: A Review

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