Novel skeleton terpenes from Celastrus hypoleucus with anti-tumor activities

Wang, Kuiwu; Mao, Jianshan; Tai, Yuanpo; Pan, Yuanjiang

doi:10.1016/j.bmcl.2006.01.021

Cited by 30 publications

(7 citation statements)

References 14 publications

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“…More than 100 compounds have been isolated and purified from three species, including Celastrus hypoleucus (Oliv.) Warb [ 1 ], Celastrus hypoleucus [ 2 ], and Microtropis triflora Merr [ 3 ] belonging to the Celastraceae family. The structures were determined by IR, UV, MS, and NMR, respectively, and 13 of them were new compounds.…”

Section: Introductionmentioning

confidence: 99%

A New Friedelane Type Triterpene from Euonymus hederaceus

Sun

et al. 2009

Molecules

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Euonymus hederaceus is distributed widely in the south of China; its stems and leaves have been used as folk medicines to treat many diseases such as renal deficiency and chronic diarrhea, traumatic injury, and abnormal menstruation. Chemical investigation of the leaves and stems of Euonymus hederaceus resulted in the isolation for the first time and characterization of a new friedelane type triterpene with a molecular mass of 472 and molecular formula of C30H48O4 by high resolution mass spectrometry. The 1H-NMR 13C-NMR and DEPT1350 spectra matched the characteristic data of the proposed triterpene skeleton. The compound was finally identified as 28-hydroxyfriedelan-3-one-29-oic acid on the basis of spectroscopic evidence, including two dimensional nuclear magnetic resonance as well as its IR spectrum.

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Section: Introductionmentioning

confidence: 99%

A New Friedelane Type Triterpene from Euonymus hederaceus

Sun

et al. 2009

Molecules

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“…5Y9 In particular, the triterpenoid oleanen, isolated from a methanol extract of Celastrus hypoleucus, inhibits proliferation and induces apoptosis in the human colon cancer cell line RKO in vitro. 10 In this study, we found that oleanen strongly inhibited proliferation and induced apoptosis in human cervical cancer HeLa cells. Furthermore, oleanen induced apoptosis in HeLa cells by inducing the expression of proapoptotic proteins such as Bim.…”

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confidence: 60%

Oleanen Induces Apoptosis of Cervical Cancer Cells by Up-Regulation of Bim

Gan¹,

Chen

Zhang³

et al. 2012

International Journal of Gynecological Cancer

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“…The isomers of compound 1, such as daturadiol 16 and 12-oleanene-3β-6α-diol 17 which were oleanane-type triterpenoids with a double bond at C-12 and C-13, have been reported in previous literature. The NMR data of compound 1 were very different from the above two known triterpenoids daturadiol and 12-oleanene-3β-6α-diol.…”

Section: Resultsmentioning

confidence: 89%

Triterpenoids with α-glucosidase inhibitory activities from the roots of Codonopsis pilosula var. modesta

Wang

Zhao

et al. 2020

Journal of Chemical Research

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A new taraxerane-type triterpenoid, codopimodol A (1), together with two known triterpenoids (2 and 3), were isolated from the EtOH extract of the roots of Codonopsis pilosula var. modesta (Campanulaceae). The structure of the new compound was identified by high-resolution electrospray ionization mass spectrometry and extensive spectroscopic analyses, particularly one-dimensional and two-dimensional NMR and IR. All the compounds were first isolated from C. pilosula var. modesta. Compounds 1 and 3 exhibited potential α-glucosidase inhibitory activities.

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Novel skeleton terpenes from Celastrus hypoleucus with anti-tumor activities

Cited by 30 publications

References 14 publications

A New Friedelane Type Triterpene from Euonymus hederaceus

A New Friedelane Type Triterpene from Euonymus hederaceus

Oleanen Induces Apoptosis of Cervical Cancer Cells by Up-Regulation of Bim

Triterpenoids with α-glucosidase inhibitory activities from the roots of Codonopsis pilosula var. modesta

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