Novel spectrophotometric method for determination of cinacalcet hydrochloride in its tablets via derivatization with 1,2-naphthoquinone-4-sulphonate

Darwish, Ibrahim A.; Al‐Shehri, Mona M.; El-Gendy, Manal A.

doi:10.1186/1752-153x-6-11

Cited by 11 publications

(8 citation statements)

References 19 publications

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“…Subsequently, Legua and co-workers [56,57] applied this method to determine amphetamines in urine. Figure 3 highlights some important drugs containing primary or secondary amino groups in capsules, tablets, powders, formulations, formulations of associated drugs, injection formulations, and biological fluids [42,[58][59][60][61][62][63][64][65][66][67][68][69].…”

Section: Synthesis Of 4-amino-β-naphthoquinones and Analogues From β-Nqsmentioning

confidence: 99%

1,2-Naphthoquinone-4-sulfonic acid salts in organic synthesis

Ribeiro¹,

Ferreira²,

Borges³

et al. 2022

Beilstein J. Org. Chem.

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Several low molecular weight naphthoquinones are very useful in organic synthesis. These compounds have given rise to thousands of other naphthoquinones that have been tested against various microorganisms and pharmacological targets, including being used in the preparation of several drugs that are on the pharmaceutical market. Among these naphthoquinones, the series of compounds prepared from 1,2-naphthoquinone-4-sulfonic acid salts (β-NQS) stands out. In addition to being used in organic synthesis, they are excellent analytical derivatization reagents to spectrophotometrically determine drugs containing primary and secondary amino groups. This review summarizes the literature involving β-NQS.

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Section: Synthesis Of 4-amino-β-naphthoquinones and Analogues From β-Nqsmentioning

confidence: 99%

1,2-Naphthoquinone-4-sulfonic acid salts in organic synthesis

Ribeiro¹,

Ferreira²,

Borges³

et al. 2022

Beilstein J. Org. Chem.

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“…The reagent NQS has been a useful reagent in developing simple spectrophotometric method for the determination of pharmaceutically important drugs [14]. The reaction proceeded by the nucleophilic substitution of NQS at secondary amino group of the drug GPZ in slightly alkaline medium to yield a reddish-orange colored chromogen.…”

Section: Methods Amentioning

confidence: 99%

Spectrophotometric Methods for the Determination of Anti-diabetic Drug Glipizide in Pure and Pharmaceutical Formulations

Ismail¹,

Narayana²

2016

Eurasian J Anal Chem

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Four simple and precise spectrophotometric methods were developed and optimized for the assay of glipizide (GPZ) in pure form and in its pharmaceutical preparations. Method A was based on the reaction of drug with 1,2-naphthoquinone-4-sulfonate (NQS) in alkaline medium to form orange colored product (λmax 456 nm). In the method B, drug reduced the reagent tetrazolium blue (TB) which lead to the formation of intense violet colored formazan (λmax 515 nm). The method C employed Folin-Ciocalteu reagent (FC) that reacted with drug in alkaline medium to form blue colored complex (λmax 760 nm). Method D was based on the reduction of iron(III) to iron(II) by the drug and their complexation with bathophenanthroline (BPT) to form pink colored complex (λmax 547 nm). Linearity of Beer's plots was observed in the concentration range of 10.00 -100.00 µg mL -1 , 2.00 -22.00 µg mL -1 , 5.00 -40.00 µg mL -1 , 0.50 -7.50 µg mL -1 for method A, B, C and D respectively. The proposed methods were validated and values of analytical parameters like molar absorptivity, Sandell's sensitivity, limits of detection and quantification were also calculated. The methods were found to be selective for the quantitative determination of GPZ in commercially available formulations.

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“…There are several spectroscopic methods reported for estimation of Cinacalcet. (Darwish et. Al., 2012;Loni et.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Stability Indicative Analysis for Cinacalcet Hydrochloride and Stress Study

Chaudhari¹,

Lokhande²,

Yadav³

2021

JSR

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The present research deals with development and validation of simple, economical, for Cinacalcet Hydrochloride along with its process impurities. The mobile phase consists of phosphate buffer (pH 3.0) and Acetonitrile. The YMC pack butyl column was used for separation. The LOD value for Cinacalcet and known impurities were about 0.17 ppm and 0.20 ppm respectively, whereas LOQ values were about 0.50 and 0.60 ppm. The regression coefficient was more than 0.999. The % accuracy for each impurity was within the range of 90 to 110. The method is capable to quantify the degradant impurities generated during stress study, thus proving stability indicative nature of method.

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Novel spectrophotometric method for determination of cinacalcet hydrochloride in its tablets via derivatization with 1,2-naphthoquinone-4-sulphonate

Cited by 11 publications

References 19 publications

1,2-Naphthoquinone-4-sulfonic acid salts in organic synthesis

1,2-Naphthoquinone-4-sulfonic acid salts in organic synthesis

Spectrophotometric Methods for the Determination of Anti-diabetic Drug Glipizide in Pure and Pharmaceutical Formulations

Development and Validation of Stability Indicative Analysis for Cinacalcet Hydrochloride and Stress Study

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