Novel subgenotype D11 of hepatitis B virus in NaPo County, Guangxi, bordering Vietnam

Ren, Chuang-Chuang; Chen, Qin-Yan; Wang, Xueyan; Harrison, Tim J.; Yang, Qingli; Hu, Liping; Liu, Huabing; He, Xiang; Jia, Hui-Hua; Fang, Zhong-Liao

doi:10.1099/jgv.0.001257

Cited by 7 publications

(7 citation statements)

References 43 publications

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“…Genotypes comprise several subgenotypes having a pairwise divergence of 4% to 7.5%. Over the years, the discovery of new subgenotypes has been extensively described [6][7][8][9][10], but there have been many debates about the possible misclassification of some of them [11]. In the absence of an ICTV classification, several attempts have been made to standardize the ICTV classification system [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide

Marcelino

Ezeonwumelu

Janeiro³

et al. 2022

PLoS ONE

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In Portugal, the genetic diversity, origin of HBV and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are endemic in Portugal. HBV pol gene was sequenced from 130 patients followed in Lisbon. HBV genotype A was the most prevalent (n = 54, 41.5%), followed by D (n = 44, 33.8%), and E (n = 32, 24.6%). Spatio-temporal evolutionary dynamics was reconstructed in BEAST using a Bayesian Markov Chain Monte Carlo method, with a GTR nucleotide substitution model, an uncorrelated lognormal relaxed molecular clock model, a Bayesian skyline plot, and a continuous diffusion model. HBV subgenotype D4 was the first to be introduced in Portugal around 1857 (HPD 95% 1699–1931) followed by D3 and A2 a few decades later. HBV genotype E and subgenotype A1 were introduced in Portugal later, almost simultaneously. Our results indicate a very important role of Portugal in the exportation of subgenotypes D4 and A2 to Brazil and Cape Verde, respectively, in the beginning of the XX century. This work clarifies the epidemiological history of HBV in Portugal and provides new insights in the early and global epidemic history of this virus.

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Section: Introductionmentioning

confidence: 99%

Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide

Marcelino

Ezeonwumelu

Janeiro³

et al. 2022

PLoS ONE

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“…Genotypes B (with sub genotypes B1–B10) and genotype C (with sub-genotypes C1–C17) are more frequent in Asia 10 – 21 . Genotype D (with sub-genotypes D1–D12) is most prevalent in southern Europe Mediterranean, India and Russia 22 – 25 . Genotype F (with 6 sub-genotypes F1–F6) has a worldwide distribution but mainly endemic in central and southern America 26 , 27 .…”

Section: Introductionmentioning

confidence: 99%

“…Genotypes B (with sub genotypes B1-B10) and genotype C (with sub-genotypes C1-C17) are more frequent in Asia [10][11][12][13][14][15][16][17][18][19][20][21] . Genotype D (with sub-genotypes D1-D12) is most prevalent in southern Europe Mediterranean, India and Russia [22][23][24][25] . Genotype F (with 6…”

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confidence: 99%

Mapping hepatitis B virus genotypes on the African continent from 1997 to 2021: a systematic review with meta-analysis

Kafeero

Ndagire

Ocama

et al. 2023

Sci Rep

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Hepatitis B virus (HBV) has ten genotypes (A–J) and over 40 sub-genotypes based on the divergence of ≥ 8% and 4 to < 8% in the complete genome respectively. These genotypes and sub-genotypes influence the disease prognosis, response to therapy and route of viral transmission. Besides, infection with mixed genotypes and recombinant genotypes has also been reported. This study aimed at mapping the de novo genotypes and correlate them with the immigration trends in order to inform future research on the underlying reasons for the relative distribution of HBV genotypes from a large sample size pooled from many primary studies. Data was extracted from 59 full research articles obtained from Scopus, PubMed, EMBASE, Willy library, African Journal Online (AJOL) and Google Scholar. Studies that investigated the genotypes, sub-genotypes, mixed genotypes and recombinant were included. The Z-test and regression were used for the analysis. The study protocol is registered with PROSPERO under the registration number CRD42022300220. Overall, genotype E had the highest pooled prevalence significantly higher than all the other genotypes (P < 0.001). By region, genotype A posted the highest pooled prevalence in eastern and southern Africa, E in west Africa and D in north Africa (P < 0.0001). Regarding the emerging genotypes B and C on the African continent, genotype B was significantly higher in south Africa than C (P < 0.001). In contrast, genotype C was significantly higher in east Africa than west Africa (P < 0.0001). The A1 and D/E were the most diverse sub-genotypes and genotype mixtures respectively. Finally, we observed a general progressive decrease in the prevalence of predominant genotypes but a progressive increase in the less dominant by region. Historical and recent continental and intercontinental migrations can provide a plausible explanation for the HBV genotype distribution pattern on the African continent.

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“…Subclasses within the same genotype, defined as subgenotypes, are characterized by a nucleotide divergence >4% and <7.5% (Pourkarim et al, 2010). HBV sub/genotypes have a distinct geographical distribution (Pineda-Peña et al, 2015;Pourkarim et al, 2014;Ren et al, 2019) with different clinical outcomes and response to antiviral therapies (Amini-Bavil-Olyaee et al, 2011;Mina et al, 2015;McMahon, 2009). To date, several subgenotypes have been identified for genotypes D (D1-D11).…”

Section: Introductionmentioning

confidence: 99%

“…Subgenotypes D2 and D3 have been isolated in North-Eastern Europe and Central Asia (Pineda-Peña et al, 2015), while HBV subgenotypes D4-D8 were present in African countries. Finally, subgenotype D9 is mainly found in India, D10 in Ethiopia and D11 is circulating in Vietnam (Ren et al, 2019). HBV genotype A is also classified in different subgenotypes and quasi-subgenotypes (A1-A7).…”

Section: Introductionmentioning

confidence: 99%

Novel hepatitis B virus subgenotype A8 and quasi-subgenotype D12 in African–Belgian chronic carriers

Thijssen

Trovão

Mina³

et al. 2020

International Journal of Infectious Diseases

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Background: Hepatitis B virus (HBV) is a public health threatening virus and is classified into more than eight genotypes and more than forty subgenotypes. Objectives: To characterize and propose novel strains assigned as A8 and D12. Methods: Four out of 133 HBV complete genome sequences, isolated from Belgian chronic carriers with African origin were phylogenetically analyzed. Results: Phylogenetic analyses of HBV genotypes A and D strains exhibited separate clusters supported by significant bootstrap values. The two genotype A strains isolated from Congolese patients, and two genotype D strains isolated from Ghanaian carriers clustered separately from the other known subgenotypes A (A1-A6 and quasi-subgenotypes) and subgenotypes D (D1-D11). The mean intersubgenotypic nucleotide divergence over the full-length genome sequence between the novel strains (A8 and D12) and A1-A7 and D1-D11 subgenotypes was higher than 4%. Conclusions: Phylogenetic analysis of the full-length HBV genome sequences revealed a novel subgenotype and quasi-subgenotype based on the nucleotide divergence and identification of novel amino acids motifs in different ORFs. We identified two strains of the novel subgenotype A8 and two strains of the novel quasi-subgenotype D12. Notably, the analysis demonstrated that the subgenotype A8 strains are a basal lineage that diverged before the other African subgenotypes A.

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Novel subgenotype D11 of hepatitis B virus in NaPo County, Guangxi, bordering Vietnam

Cited by 7 publications

References 43 publications

Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide

Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide

Mapping hepatitis B virus genotypes on the African continent from 1997 to 2021: a systematic review with meta-analysis

Novel hepatitis B virus subgenotype A8 and quasi-subgenotype D12 in African–Belgian chronic carriers

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