Novel Tandem Three Consecutive Reactions: Aza-Wittig, Imine Condensation and Electrophilic Aromatic Substitution Strategy to Indolizine Synthesis

González-Rodríguez, Julio C.; González‐Romero, Carlos; Cuevas-Yáñez, Erick; Vega, Juan J. Mejía; Jankowski, Christopher K.; Corona‐Becerril, David

doi:10.4236/ijoc.2021.112006

Cited by 2 publications

References 42 publications

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Thienoindolizines and their Benzo‐Fused Derivatives: Synthesis and Physical Properties

Ausekle

Ehlers

Villinger

et al. 2023

Chemistry A European J

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A series of thienoindolizine structural isomers have been synthesized in a one-pot, two-step procedure starting from easily accessible gem-difluoroalkene functionalized bromothiophenes. The developed method gives easy access to a range of thienoindolizine products containing thieno[3,2g]-, thieno[3,4-g]-and thieno[2,3-g]indolizine core structures. The described synthesis strategy consists of a base mediated, transition metal free nucleophilic substitution of fluorine atoms by nitrogen containing heterocycles followed by a Pd catalyzed intramolecular cyclization. A series of 22 final product examples has been obtained with yields ranging from 29 % to 95 %. UV/Vis absorption, fluorescence spectroscopy, fluorescence lifetime measurements and cyclic voltammetry were carried out with selected final products to evaluate structural effects on photophysical and electrochemical properties. (TD)DFT and NICS calculations were performed to provide insight into the electronic properties of the four core molecular structures.

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Thienoindolizines and their Benzo‐Fused Derivatives: Synthesis and Physical Properties

Ausekle

Ehlers

Villinger

et al. 2023

Chemistry A European J

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Pentacoordinated and hexacoordinated compounds

Pajkert,

Röschenthaler

2024

Organophosphorus Chemistry

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The chemistry of penta- and hexa-coordinated compounds continues to expand in its breadth and application. In this context, the synthesis, properties and structural investigations on novel cage-phosphoranes, spirophosphoranes, fluorophosphoranes, metallophosphoranes and pentacoordinated corroles have been briefly described. Pentacoordinated phosphoranes have been also postulated as intermediates and transition states in the synthesis of isoquinolines, indolizines,1,3-dienes or furan-monogenes as well as in the carbamate version of the Kabachnik–Field reaction. Furthermore, studies on hexacoordinated phosphorus(v) corroles, carbene-fluorophosphorane adducts and transition metal complexes stabilized by an FAP anion have been reported.

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Novel Tandem Three Consecutive Reactions: Aza-Wittig, Imine Condensation and Electrophilic Aromatic Substitution Strategy to Indolizine Synthesis

Cited by 2 publications

References 42 publications

Thienoindolizines and their Benzo‐Fused Derivatives: Synthesis and Physical Properties

Thienoindolizines and their Benzo‐Fused Derivatives: Synthesis and Physical Properties

Pentacoordinated and hexacoordinated compounds

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