Novel Targets and Interventions for Cognitive Complications of Diabetes

Wolf, Victoria; Abdul, Yasir; Ergul, Adviye

doi:10.3389/fphys.2021.815758

Cited by 6 publications

(2 citation statements)

References 146 publications

(224 reference statements)

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“…Interestingly, decreased SUA was observed in diabetic patients with DPN. Similarly, a previous study showed lower SUA in T2DM patients with mild cognitive impairment than those without cognition decline [41], which is a kind of dysfunction in the central nervous system [42,43]. To confirm the occurrence of DPN, the conduction velocity of nerve was compared.…”

Section: Discussionmentioning

confidence: 94%

Serum Uric Acid Levels Are Related to Diabetic Peripheral Neuropathy, Especially for Motor Conduction Velocity of Tibial Nerve in Type 2 Diabetes Mellitus Patients

Zhang

Vladmir

Zhang

et al. 2023

Journal of Diabetes Research

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Background. Oxidative stress is one of the most critical factors that contribute to the pathogenesis of neuronal damage, including diabetic peripheral neuropathy (DPN). Uric acid is a kind of natural antioxidant that plays a major role in the antioxidant capacity against oxidative stress. Here, we aim to determine the role of serum uric acid (SUA) in the DPN of patients with type 2 diabetes mellitus (T2DM). Patients and Methods. 106 patients with T2DM were recruited and divided into the DPN group and the control group. Clinical parameters, especially for motor nerve fiber conduction velocity and sensory nerve fiber conduction velocity, were collected. Differences between T2DM patients with and without DPN were compared. Correlation and regression analyses were performed to explore the association between SUA and DPN. Results. Compare with 57 patients with DPN, 49 patients without DPN showed lower HbA1c and elevated SUA levels. Additionally, SUA levels are negatively associated with the motor conduction velocity of tibial nerve with or without adjusting for HbA1c. Besides, it is suggested that decreased SUA levels may influence the motor conduction speed of the tibial nerve by multiple linear regression analysis. Moreover, we demonstrated that decreased SUA level is a risk factor for DPN in patients with T2DM by binary logistic regression analysis. Conclusion. Lower SUA is a risk factor for DPN in patients with T2DM. Additionally, decreased SUA may influence the damage of peripheral neuropathy, especially for motor conduction velocity of the tibial nerve.

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Section: Discussionmentioning

confidence: 94%

Serum Uric Acid Levels Are Related to Diabetic Peripheral Neuropathy, Especially for Motor Conduction Velocity of Tibial Nerve in Type 2 Diabetes Mellitus Patients

Zhang

Vladmir

Zhang

et al. 2023

Journal of Diabetes Research

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“…Микрососудистые осложнения включают диабетическую ретинопатию, нефропатию, невропатию, энцефалопатию и др. [14,15,17,18], к макрососудистым в первую очередь относят атеросклеротические изменения в сосудах сердца и головного мозга (ГМ) [9,14,15].…”

Section: Introductionunclassified

Cognitive impairments in type 1 diabetes mellitus

Bykov

Baturin

2023

Sibirskij nauchnyj medicinskij zhurnal

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Type 1 diabetes mellitus (DM) is one of the most prevalent endocrinological disorders of childhood. This disorder is accompanied by numerous micro- and macrovascular complications that reduce children’s life expectancy and increase healthcare costs. Central nervous system (CNS) damage in children and adolescents with type 1 DM is a fairly common but poorly studied complication. The leading role among CNS changes is played by cognitive dysfunction (CD). The pathophysiological aspects of CD in type 1 DM haven’t yet been understood completely. The three main triggers are hypoglycemia, chronic moderate hyperglycemia, and acute hyperglycemia (diabetic ketoacidosis). Evidence is presented to show the development of morphological abnormalities of the brain with progression of type 1 DM in children. Damage in the formation of white and gray matter, hippocampus, amygdala, the processes of myelination disorders have been described, which can also be the cause of CD development in this contingent of patients. Peculiarities ofclinical manifestations of CD in children and adolescents with type 1 DM depending on the localization of the brain lesion are described. A more pronounced CD was found in cases when DM debuts in early childhood (up to 5 years). Timely diagnosis and correction of CD in children and adolescents with type 1 DM can improve the therapeutic and prophylactic prognosis in this disease.

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Inhibition of the Proteasome Regulator PA28 Aggravates Oxidized Protein Overload in the Diabetic Rat Brain

Wang

Zhou

et al. 2023

Cell Mol Neurobiol

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Novel Targets and Interventions for Cognitive Complications of Diabetes

Cited by 6 publications

References 146 publications

Serum Uric Acid Levels Are Related to Diabetic Peripheral Neuropathy, Especially for Motor Conduction Velocity of Tibial Nerve in Type 2 Diabetes Mellitus Patients

Serum Uric Acid Levels Are Related to Diabetic Peripheral Neuropathy, Especially for Motor Conduction Velocity of Tibial Nerve in Type 2 Diabetes Mellitus Patients

Cognitive impairments in type 1 diabetes mellitus

Inhibition of the Proteasome Regulator PA28 Aggravates Oxidized Protein Overload in the Diabetic Rat Brain

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