Novel Technologies for Vaccine Development

Lukashevich, Igor S.; Shirwan, Haval

doi:10.1007/978-3-7091-1818-4

2014

DOI: 10.1007/978-3-7091-1818-4

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Novel Technologies for Vaccine Development

Igor S. Lukashevich¹,

Haval Shirwan²

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Cited by 2 publications

References 569 publications

(725 reference statements)

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Veterinary vaccine development: The helical project

Dereja¹

2020

Insights Vet Sci

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Vaccine production process have been fuzzy journey to the public and, in some degrees, to those in the setting. By clearly showing the lengthy and challenging journey of vaccine development process, thereby suggesting the economic and health implication of improper use of veterinary vaccines, the paper tries to add the attention given to infection prevention. Starting from the foundations, the types and requirements of veterinary vaccines are described. The paper concludes with current research and regulatory quos in the topic.

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Veterinary vaccine development: The helical project

Dereja¹

2020

Insights Vet Sci

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Single-Dose Immunogenic DNA Vaccines Coding for Live-Attenuated Alpha- and Flaviviruses

Pushko,

Lukashevich,

Johnson

et al. 2024

Viruses

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Single-dose, immunogenic DNA (iDNA) vaccines coding for whole live-attenuated viruses are reviewed. This platform, sometimes called immunization DNA, has been used for vaccine development for flavi- and alphaviruses. An iDNA vaccine uses plasmid DNA to launch live-attenuated virus vaccines in vitro or in vivo. When iDNA is injected into mammalian cells in vitro or in vivo, the RNA genome of an attenuated virus is transcribed, which starts replication of a defined, live-attenuated vaccine virus in cell culture or the cells of a vaccine recipient. In the latter case, an immune response to the live virus vaccine is elicited, which protects against the pathogenic virus. Unlike other nucleic acid vaccines, such as mRNA and standard DNA vaccines, iDNA vaccines elicit protection with a single dose, thus providing major improvement to epidemic preparedness. Still, iDNA vaccines retain the advantages of other nucleic acid vaccines. In summary, the iDNA platform combines the advantages of reverse genetics and DNA immunization with the high immunogenicity of live-attenuated vaccines, resulting in enhanced safety and immunogenicity. This vaccine platform has expanded the field of genetic DNA and RNA vaccines with a novel type of immunogenic DNA vaccines that encode entire live-attenuated viruses.

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Novel Technologies for Vaccine Development

Cited by 2 publications

References 569 publications

Veterinary vaccine development: The helical project

Veterinary vaccine development: The helical project

Single-Dose Immunogenic DNA Vaccines Coding for Live-Attenuated Alpha- and Flaviviruses

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