Novel technologies to improve the treatment of endodontic microbial infections: Inputs from a drug delivery perspective

Miranda, Thamires C.; Andrade, Jayanaraian F. Martins; Gelfuso, Guilherme M.; Cunha-Filho, Marcílio; Oliveira, Laudimar A.; Gratieri, Taís

doi:10.1016/j.ijpharm.2023.122794

Cited by 7 publications

(2 citation statements)

References 109 publications

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“…Specifically, for teeth with periapical lesions exceeding 5 mm, the success rates have been reported to vary between 38% and 80% [ 10 , 11 ]. For a long time, many studies have focused on how to improve the debridement of the root canal system and the outcome of root canal treatment [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoarchitectonics-Based Materials as a Promising Strategy in the Treatment of Endodontic Infections

Xiao,

Sun,

Huang

et al. 2024

Pharmaceutics

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Endodontic infections arise from the interactive activities of microbial communities colonizing in the intricate root canal system. The present study aims to update the latest knowledge of nanomaterials, their antimicrobial mechanisms, and their applications in endodontics. A detailed literature review of the current knowledge of nanomaterials used in endodontic applications was performed using the PubMed database. Antimicrobial nanomaterials with a small size, large specific surface area, and high chemical activity are introduced to act as irrigants, photosensitizer delivery systems, and medicaments, or to modify sealers. The application of nanomaterials in the endodontic field could enhance antimicrobial efficiency, increase dentin tubule penetration, and improve treatment outcomes. This study supports the potential of nanomaterials as a promising strategy in treating endodontic infections.

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Section: Introductionmentioning

confidence: 99%

Nanoarchitectonics-Based Materials as a Promising Strategy in the Treatment of Endodontic Infections

Xiao,

Sun,

Huang

et al. 2024

Pharmaceutics

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“…Endodontic treatments aim to effectively reduce the microorganisms responsible for endodontic infections [1]. However, the complete elimination of endodontic pathogens is extremely difficult, if not impossible, with the commonly used instrument methods, due to the complex anatomy of the root canal system and the presence of lateral canals, isthmi, ramifications and fins [2]. Enterococcus faecalis is associated with secondary endodontic infections, refractory infected lesions and periapical biofilms, resulting in endodontic treatment failure [3].…”

Section: Introductionmentioning

confidence: 99%

The Evaluation of SWEEPS Plus Antimicrobial Photodynamic Therapy with Indocyanine Green in Eliminating Enterococcus faecalis Biofilm from Infected Root Canals: An In Vitro Study

et al. 2023

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Objectives: This study aimed to assess the efficacy of shockwave-enhanced emission photoacoustic streaming (SWEEPS) plus antimicrobial photodynamic therapy (aPDT) using indocyanine green (ICG) for the elimination of Enterococcus faecalis biofilm from infected root canals. Materials and Methods: thirty sound human single-canal teeth were chosen and standardized to have 12 mm of root length. The root canals were shaped and prepared by means of ProTaper rotary files. After sterilization of the teeth, the canals were inoculated with E. faecalis for 2 weeks. The teeth were then randomly divided into six groups (n = five) of control, ICG, ICG + 808 nm diode laser, ICG + SWEEPS, ICG + 808 nm diode laser + SWEEPS, and 5.25% sodium hypochlorite (NaOCl). Following treatment, the number of colony-forming units (CFUs)/mL were calculated for each group. Statistical analysis was carried out using one-way ANOVA. For multiple comparisons, Tukey’s test was used as the post hoc test. Results: NaOCl alone showed the highest efficacy (p < 0.001). The ICG + 808 nm diode laser + SWEEPS group displayed significantly lower amounts of bacteria than either the ICG + 808 nm diode laser or SWEEPS (p < 0.001). There was a statistically significant difference detected between the ICG + 808 nm diode laser and ICG + SWEEPS (p = 0.035). Conclusions: SWEEPS can effectively increase the photosensitizer distribution in the root canal space, and its application along with irrigants can bring about promising results.

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Donor–acceptor type COFs with multiple fluorine groups as electron storage units to promote antimicrobial performance

Ma,

Lin,

Zhu

et al. 2024

Colloids and Surfaces B: Biointerfaces

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Novel technologies to improve the treatment of endodontic microbial infections: Inputs from a drug delivery perspective

Cited by 7 publications

References 109 publications

Nanoarchitectonics-Based Materials as a Promising Strategy in the Treatment of Endodontic Infections

Nanoarchitectonics-Based Materials as a Promising Strategy in the Treatment of Endodontic Infections

The Evaluation of SWEEPS Plus Antimicrobial Photodynamic Therapy with Indocyanine Green in Eliminating Enterococcus faecalis Biofilm from Infected Root Canals: An In Vitro Study

Donor–acceptor type COFs with multiple fluorine groups as electron storage units to promote antimicrobial performance

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