Novel thiocyanato complexes with potent cytotoxic and antimicrobial properties

Abstract

The aim of the present study was to assess the cytotoxic and antimicrobial properties of seven new thiocyanato complexes: Ni(C(9)H(11)N(2)O)(SCN), Cu(C(9)H(11)N(2)O)(SCN), Pd(C(9)H(11)N(2)O)(SCN), Pt(C(9)H(11)N(2) O) (SCN), K[Ti(C(9)H(11)N(2)O)(SCN)(3)], Au(C(9)H(11)N(2)O)(SCN), and K[V(O)(C(9)H(11)N(2)O)(SCN)] (T(1)-T(7), respectively). All the complexes showed toxicity against brine shrimp nauplii (Artemia salina L.). The titanium-based complex, T(5), exhibited potent toxicity, with a lethal concentration 50% (the concentration of test compound that kills 50% of A. salina) value of 1.59 microg mL(-1). These new complexes also exhibited promising antibacterial and antifungal properties. A macrodilution technique was used to estimate the minimum inhibitory concentrations of the seven bioactive complexes. Minimum inhibitory concentrations were found to be 8-64 microg mL(-1) against the tested bacterial species.

Surfactant–cobalt(III) complexes: Synthesis, critical micelle concentration (CMC) determination, DNA binding, antimicrobial and cytotoxicity studies

“…The discdiffusion method is highly effective for rapidly growing microorganisms and the activities of the test complexes are expressed by measuring the diameter of the zone of inhibition [25]. The complexes were stored dry at room temperature and dissolved in DMSO (1%).…”

Surfactant-Ruthenium(II) Complexes: Synthesis, Characterization, DNA Binding, Anticancer and Antimicrobial Activity

“…Antimicrobial screening: The antibacterial activities of complexes were evaluated using disk diffusion method by Kirby-Bauer disc diffusion process [31]. This method is extremely effective for fast emergent microorganisms and the actions of the test complexes are noted by assessing the diameter of the zone of inhibition [28,32]. The surfactant-ruthenium(II) complexes were taken in extreme dry condition at room temperature and dissolved in 1 % DMSO.…”

Synthesis, Characterization and Antimicrobial activity of protected dipeptides and their deprotected analogs

“…In this method the antimicrobial activity of test compounds was examined by measuring the diameter of zone of inhibition 9 . The antimicrobial activity was checked against two fungal strains Aspergillus fumigatus (NCIM-902), Pencillium chrysogenum(NCIM-738) and two Gram-negative E. coli (NCIM-2563), Salmonella typhimurium(NCIM-2501) bacterial strains.…”