Novel Treatments for Chronic Ocular Surface Pain

Mangwani-Mordani, Simran; Goodman, Courtney F

doi:10.1097/ico.0000000000003193

Cited by 4 publications

(1 citation statement)

References 78 publications

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“…59 Other therapies that have been studied in the treatment of NOP include transcutaneous trigeminal stimulation, periocular injections of bupivacaine/methylprednisolone, botulinum toxin, and blockade of sympathetic and parasympathetic ganglions. 60 These approaches can be considered in individuals with SS, as appropriate.…”

Section: Therapeutic Implications Of Nerve Alterations In Sjögren Syn...mentioning

confidence: 99%

Rethinking Sjögren Beyond Inflammation: Considering the Role of Nerves in Driving Disease Manifestations

Sanchez,

Dobzinski,

Fox

et al. 2024

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Sjögren syndrome (SS) is a chronic inflammatory autoimmune disease characterized by destruction of mucosal glands resulting in dry eye and dry mouth. Ocular presentations can be heterogenous in SS with corneal nerves abnormalities that are structural, functional, or both. Some individuals present with corneal hyposensitivity, with a phenotype of decreased tear production and epithelial disruption. Others present with corneal hypersensitivity, with a phenotype of neuropathic pain including light sensitivity and pain out of proportion to signs of tear dysfunction. A similar correlate can be found outside the eye, with dry mouth predominating in some individuals while pain conditions predominate in others. Understanding how nerve status affects SS phenotype is an important first step to improving disease management by targeting nerve abnormalities, as well as inflammation.

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Section: Therapeutic Implications Of Nerve Alterations In Sjögren Syn...mentioning

confidence: 99%