Novel Tumor-Microenvironment-Based Sequential Catalytic Therapy by Fe(II)-Engineered Polydopamine Nanoparticles

Abstract

Traditional tumor treatments suffer from severe side effects on account of their invasive process and inefficient outcomes. Featuring a unique physical microenvironment, the tumor microenvironment (TME) provides a new research direction for designing more efficient and safer treatment paradigms. In this study, we fabricated a polydopamine (PDA)-based TMEresponsive nanosystem, which successfully integrates glucose degradation, the Fenton reaction, and photothermal therapy for efficient cancer therapy. Through a convenient hydrothermal method, Fe 2+ -doped Fe(II)−PDA nanoparticles were successfully fabricated, which show an excellent photothermal effect and interesting reactivity for the Fenton reaction. Instead of introducing toxic anticancer agents, natural glucose oxidase (GOD) was grafted on Fe(II)−PDA, forming a cascade catalytic nanomedicine for a specific response to the glucose in TME. GOD grafted on Fe(II)−PDA−GOD is ought to catalyze abundant glucose in TME into gluconic acid and H 2 O 2 . The concomitant generation of H 2 O 2 can enhance the efficiency of the sequential Fenton reaction, producing abundant hydroxyl radicals ( • OH) for cancer therapy. Besides, the overconsumption of intratumoral glucose also could inhibit tumor growth by reducing the energy supply. Taken together, the in vitro and in vivo antitumor studies of such TME-based Fe(II)−PDA−GOD nanosystems displayed a favorable synergistic potency of glucose degradation, the Fenton reaction, and photothermal therapy against tumor growth. Our design expands the biological application of multifunctional PDA while providing novel strategies toward effective antitumor treatment with minimal side effects.

Fe-Doped polydopamine nanoparticles with peroxidase-mimicking activity for the detection of hypoxanthine related to meat freshness

“…Fe-PDA nanoparticles were prepared using a high-temperature hydrothermal method. 34 In brief, 11.4 mg DOPA was first adequately dissolved in deionized water (30.0 mL), and then 16.2 mg FeCl 3 was added at a molar ratio of Fe/DOPA of 1 : 1. At this time, the color of the solution swiftly changed from colorless to green.…”

Recent Advances in a Polydopamine-Mediated Antimicrobial Adhesion System

“…Polydopamine finds numerous applications even as stable suspension of nanoparticles (NPs), particularly as biomaterials. The use of PDA/hybrids in various fields, e.g., converting light to heat for cancer treatment by hyperthermia ( Liu F. et al, 2015 ; Dong et al, 2016 ; Wang X. et al, 2016 ; Li Y. et al, 2017 ; Nieto et al, 2018 ; Tian and Lei, 2019 ), catalytic therapy for tumors ( Zhu et al, 2019 ), and for sensing ( Kong et al, 2016 ; Wang Z. et al, 2017 ; Zhao et al, 2017 ; Gu et al, 2018 ), as well as PDA NPs loaded scaffolds in the field of tissue engineering ( Deng et al, 2019 ), are all worth mentioning. A review article that highlights the progress in fluorescent PDA nanomaterials has been published by Yang et al (2020b) .…”

Fenton/Fenton-like metal-based nanomaterials combine with oxidase for synergistic tumor therapy

“…Zhu et al [ 109 ] prepared a TME-reactive nanosystem Fe(II)-PDA-GOx (Fig. 11 , A1, A2) based on polydopamine (PDA).…”

“…A3 The antitumor effects of nanoparticles in vivo and in vitro under different treatments. Reproduced with permission from Ref [ 109 ], copyright © 2019, American Chemical Society. B1 Schematic illustration of the construction of CuS-PGH NMs for multi-gradient antitumor therapy.…”