2019
DOI: 10.1515/tnsci-2019-0001
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Nox2-dependent neuroinflammation in an EAE model of multiple sclerosis

Abstract: Background Multiple sclerosis (MS) is an inflammatory disease of the CNS, characterized by demyelination, focal inflammatory infiltrates and axonal damage. Oxidative stress has been linked to MS pathology. Previous studies have suggested the involvement of NADPH oxidase 2 (Nox2), an enzyme that catalyzes the reduction of oxygen to produce reactive oxygen species, in the MS pathogenesis. The mechanisms of Nox2 activation on MS are unknown. The purpose of this study was to investigate the effect of Nox2 deletion… Show more

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Cited by 36 publications
(24 citation statements)
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References 55 publications
(59 reference statements)
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“…1d-e,k). Nox-2 and Ho-1 have previously been found upregulated in MS, and EAE 61,62 . We also found, a tendency towards, upregulation of Nrf2, previously shown to protect against oxidative stress and correlated with disease activity in SOD1 G93A model, in the SOD1 G93A/Cpt1a mice (Fig.…”
Section: Discussionmentioning
confidence: 82%
“…1d-e,k). Nox-2 and Ho-1 have previously been found upregulated in MS, and EAE 61,62 . We also found, a tendency towards, upregulation of Nrf2, previously shown to protect against oxidative stress and correlated with disease activity in SOD1 G93A model, in the SOD1 G93A/Cpt1a mice (Fig.…”
Section: Discussionmentioning
confidence: 82%
“…IL-1β −/− mice displayed the reduced EAE and also failed to remyelinate properly involved with the function of microglia or macrophages [39] and NOS2 [40]. In addition, NOX2-deficient mice exhibited an attenuation of EAE-induced IL-1β transcription in the brain at the day 20 post-immunization [41]. In this paper, we furthered the studies of neutrophil-dependent regulation of EAE development in the mouse model.…”
Section: Discussionmentioning
confidence: 87%
“…It is well-known that BDNF could exert neuroprotective effects against brain damage. Endogenous BDNF protects against kainic acid-induced transneuronal degeneration in the substantia nigra and promotes sprouting of cortical serotonergic axons [18][19][20]. Previous studies have also proved the protective role of BDNF in EAE [21].…”
Section: Discussionmentioning
confidence: 95%