Nr1d1 affects autophagy in the skeletal muscles of juvenile Nile tilapia by regulating the rhythmic expression of autophagy-related genes

Wu, Ping; Cheng, Jia; Chen, Lin; Xiang, Jing; Pan, Ya–Xiong; Zhang, Yongzhan; Zheng, Tao; Liu, Naiyuan; Chu, Wuying; Zhang, Jianshe

doi:10.1007/s10695-019-00757-9

Cited by 7 publications

(3 citation statements)

References 22 publications

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“…In contrast, rapamycin-induced autophagy and ATG5 expression are partly inhibited by treatment with SR9009 (NR1D1 agonist), indicating that NR1D1 maintains autophagy homeostasis in mouse GCs [ 31 ]. Wu et al [ 32 ] discovered that in GSK4112 (an NR1D1 agonist)-treated tilapia, the majority of autophagy-related genes were decreased and exhibited altered rhythmicity involving Atg4c, Bnip3la, Lc3a, Lc3b , and Lc3c mRNA levels. Moreover, Chandra et al [ 33 ] demonstrated that NR1D1 activation by GSK4112 stimulated an increase in autophagic flux and lysosome formation in human macrophages via transcription factor EB (TFEB)-associated pathways.…”

Section: Nr1d1 In Autophagy Immunity Inflammation Metabolism and Agingmentioning

confidence: 99%

Targeting NR1D1 in organ injury: challenges and prospects

Zhang-sun,

Xu,

Escames

et al. 2023

Military Med Res

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Nuclear receptor subfamily 1, group D, member 1 (NR1D1, also known as REV-ERBα) belongs to the nuclear receptor (NR) family, and is a heme-binding component of the circadian clock that consolidates circadian oscillators. In addition to repressing the transcription of multiple clock genes associated with circadian rhythms, NR1D1 has a wide range of downstream target genes that are intimately involved in many physiopathological processes, including autophagy, immunity, inflammation, metabolism and aging in multiple organs. This review focuses on the pivotal role of NR1D1 as a key transcription factor in the gene regulatory network, with particular emphasis on the milestones of the latest discoveries of NR1D1 ligands. NR1D1 is considered as a promising drug target for treating diverse diseases and may contribute to research on innovative biomarkers and therapeutic targets for organ injury-related diseases. Further research on NR1D1 ligands in prospective human trials may pave the way for their clinical application in many organ injury-related disorders.

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Section: Nr1d1 In Autophagy Immunity Inflammation Metabolism and Agingmentioning

confidence: 99%

Targeting NR1D1 in organ injury: challenges and prospects

Zhang-sun,

Xu,

Escames

et al. 2023

Military Med Res

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“…Some studies have implicated it in the circadian system. Thus, daily oscillations of nr1d1 expression have been described in zebrafish ( Danio rerio ) [ 28 , 29 , 30 ], Nile tilapia ( Oreochromis niloticus ) [ 31 , 32 ], Chinese perch ( Siniperca chuatsi ) [ 33 ], Atlantic cod ( Gadus morhua ) [ 34 ], and goldfish ( Carassius auratus ) [ 35 ]. Moreover, REV-ERBα inhibits bmal expression in zebrafish [ 36 ] and goldfish (own unpublished results), in agreement with the known role of REV-ERBα as a repressor of the molecular clock transcription network [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

REV-ERBα Agonist SR9009 Promotes a Negative Energy Balance in Goldfish

Sáiz

Herrera-Castillo

Isorna

et al. 2022

IJMS

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REV-ERBα (nr1d1, nuclear receptor subfamily 1 group D member 1) is a transcriptional repressor that in mammals regulates nutrient metabolism, and has effects on energy homeostasis, although its role in teleosts is poorly understood. To determine REV-ERBα’s involvement in fish energy balance and metabolism, we studied the effects of acute and 7-day administration of its agonist SR9009 on food intake, weight and length gain, locomotor activity, feeding regulators, plasma and hepatic metabolites, and liver enzymatic activity. SR9009 inhibited feeding, lowering body weight and length gain. In addition, the abundance of ghrelin mRNA decreased in the intestine, and abundance of leptin-aI mRNA increased in the liver. Hypocretin, neuropeptide y (npy), and proopiomelanocortin (pomc) mRNA abundance was not modified after acute or subchronic SR9009 administration, while hypothalamic cocaine- and amphetamine-regulated transcript (cartpt-I) was induced in the subchronic treatment, being a possible mediator of the anorectic effects. Moreover, SR9009 decreased plasma glucose, coinciding with increased glycolysis and a decreased gluconeogenesis in the liver. Decreased triglyceride levels and activity of lipogenic enzymes suggest a lipogenesis reduction by SR9009. Energy expenditure by locomotor activity was not significantly affected by SR9009. Overall, this study shows for the first time in fish the effects of REV-ERBα activation via SR9009, promoting a negative energy balance by reducing energetic inputs and regulating lipid and glucose metabolism.

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“…Autophagy has been recognized as a circadian‐driven process in animals. The transcript levels of ATGs and the numbers of autophagosomes exhibit daily rhythms in zebrafish and Nile tilapia (Huang et al, 2016; Wu et al, 2020). The core clock gene Nr1d1 represses the expression of ATGs by directly binding to their promoters (Huang et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

The plant circadian clock regulates autophagy rhythm through transcription factor LUX ARRHYTHMO

Yang

Zhu

Chen

et al. 2022

JIPB

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Autophagy is an evolutionarily conserved degradation pathway in eukaryotes; it plays a critical role in nutritional stress tolerance. The circadian clock is an endogenous timekeeping system that generates biological rhythms to adapt to daily changes in the environment. Accumulating evidence indicates that the circadian clock and autophagy are intimately interwoven in animals. However, the role of the circadian clock in regulating autophagy has been poorly elucidated in plants. Here, we show that autophagy exhibits a robust circadian rhythm in both light/dark cycle (LD) and in constant light (LL) in Arabidopsis. However, autophagy rhythm showed a different pattern with a phase‐advance shift and a lower amplitude in LL compared to LD. Moreover, mutation of the transcription factor LUX ARRHYTHMO (LUX) removed autophagy rhythm in LL and led to an enhanced amplitude in LD. LUX represses expression of the core autophagy genes ATG2, ATG8a, and ATG11 by directly binding to their promoters. Phenotypic analysis revealed that LUX is responsible for improved resistance of plants to carbon starvation, which is dependent on moderate autophagy activity. Comprehensive transcriptomic analysis revealed that the autophagy rhythm is ubiquitous in plants. Taken together, our findings demonstrate that the LUX‐mediated circadian clock regulates plant autophagy rhythms.

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Nr1d1 affects autophagy in the skeletal muscles of juvenile Nile tilapia by regulating the rhythmic expression of autophagy-related genes

Cited by 7 publications

References 22 publications

Targeting NR1D1 in organ injury: challenges and prospects

Targeting NR1D1 in organ injury: challenges and prospects

REV-ERBα Agonist SR9009 Promotes a Negative Energy Balance in Goldfish

The plant circadian clock regulates autophagy rhythm through transcription factor LUX ARRHYTHMO

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