NRF2 is essential for iron-overload stimulated osteoclast differentiation through regulation of redox and iron homeostasis

Zhang, Jian; Zhang, Lingyan; Yao, Gang; Zhao, Hai; Wu, Shuguang

doi:10.1007/s10565-023-09834-5

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Ferroptosis Mechanism1

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2024

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Cited by 11 publications

(1 citation statement)

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“… 47 Furthermore, activation of Nrf2 reduces cellular iron uptake, increases iron storage, and limits ROS production. 48 This shows that Nrf2 plays an important protective role against ferroptosis. Inhibition of Nrf2 is also a very important mechanism of action for ferroptosis inducers.…”

Section: Ferroptosis Mechanismmentioning

confidence: 96%

Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Luo,

Bai,

Zhang

et al. 2024

DDDT

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Section: Ferroptosis Mechanismmentioning

confidence: 96%

Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Luo,

Bai,

Zhang

et al. 2024

DDDT

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Natural Products in the Prevention of Degenerative Bone and Joint Diseases: Mechanisms Based on the Regulation of Ferroptosis

Gao,

Lv,

et al. 2024

Phytotherapy Research

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Degenerative bone and joint diseases (DBJDs), characterized by osteoporosis, osteoarthritis, and chronic inflammation of surrounding soft tissues, are systemic conditions primarily affecting the skeletal system. Ferroptosis, a programmed cell death pathway distinct from apoptosis, autophagy, and necroptosis. Accumulating evidence suggests that ferroptosis is intricately linked to the pathogenesis of DBJDs, and targeting its regulation could be beneficial in managing these conditions. Natural products, known for their anti‐inflammatory and antioxidant properties, have shown unique advantages in preventing DBJDs, potentially through modulating ferroptosis. This article provides an overview of the latest research on ferroptosis, with a focus on its role in the pathogenesis of DBJDs and the therapeutic potential of natural products targeting this cell death pathway, offering novel insights for the prevention and treatment of DBJDs.

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Sulforaphane inhibits multiple myeloma cell-induced osteoclast differentiation and macrophage proliferation by elevating ferroportin1

Sun,

et al. 2024

Cancer Chemother Pharmacol

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NRF2 is essential for iron-overload stimulated osteoclast differentiation through regulation of redox and iron homeostasis

Cited by 11 publications

References 35 publications

Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Natural Products in the Prevention of Degenerative Bone and Joint Diseases: Mechanisms Based on the Regulation of Ferroptosis

Sulforaphane inhibits multiple myeloma cell-induced osteoclast differentiation and macrophage proliferation by elevating ferroportin1

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