NRP-1 expression in bladder cancer and its implications for tumor progression

Cheng, Wen; Fu, Dian; Wei, Zhifeng; Xu, Feng; Xu, Xiaofeng; Liu, You-Huang; Ge, Jingping; Tian, Feng; Han, Conghui; Zhang, Zhengyu; Zhou, Liming

doi:10.1007/s13277-014-1806-3

Cited by 31 publications

(34 citation statements)

References 20 publications

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“…Many studies documented that the increased expression of NRP1 in the tumor cells is a poor prognostic factor in malignant neoplasm since the expression of NRP1 was correlated with advanced tumor stage and/or progression in many cancers [17,[21][22][23][24]. Our study on oral squamous cell cancer patients with or without metastases supports previous findings.…”

Section: Discussionsupporting

confidence: 89%

Immunohistochemical study on neuropilin 1 (NRP1) immunoexpression in oral squamous cell carcinoma

Stasikowska-Kanicka

Wągrowska-Danilewicz

Danilewicz

2018

Folia Histochem Cytobiol.

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The present study revealed overexpression of NRP1 in OSCC, especially in OSCC patients with metasta-sis, suggesting that NRP1 could potentially contribute to metastasis of oral cancer. The correlation between the number of NRP1+ infiltrating cells and CD163+ macrophages suggests that NRP1+ infiltrating macrophages are present in tumor microenvironment and may play a role in the progressions of oral cancer.

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Section: Discussionsupporting

confidence: 89%

Immunohistochemical study on neuropilin 1 (NRP1) immunoexpression in oral squamous cell carcinoma

Stasikowska-Kanicka

Wągrowska-Danilewicz

Danilewicz

2018

Folia Histochem Cytobiol.

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“…NRP1 is considered to be a co-receptor for VEGF and is overexpressed in many human cancers. Recently, the overexpression of NRP1 has been reported to be associated with tumour progression and poor prognosis in patients with BC, but the underlying molecular mechanisms remain poorly understood [7] . Therefore, identifying the mechanisms by which NRP1 modulates the progression of BC has significance for exploring and optimizing the therapeutic strategy for urological malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…Cheng et al demonstrated that NRP1 overexpression is an independent and novel prognostic factor for BC patients, which can help clinicians identify high-risk patients for close follow-up and intensive treatment [7] .…”

Section: Discussionmentioning

confidence: 99%

“…Further, many studies have observed the abnormal high expression of NRP1 in multiple tumour types, including neuroblastomas and bile duct, gastric, pancreas, lung, prostate, breast, and colon cancers [5,7] . Additionally, there is evidence that in patients with BC, overexpression of NRP1 is a sign of poor prognosis [7] . However, the molecular mechanisms underlying how NRP1 regulates the progression of BC remain unclear.…”

Section: Introductionmentioning

confidence: 99%

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The NRP1 gene regulates proliferation, apoptosis, migration, and invasion in T24 and 5637 bladder cancer cells

Han

Dong

Hao

et al. 2020

Preprint

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Background Bladder urothelial carcinoma (BC) is a fatal invasive malignancy and the most common malignancy of the urinary system. In the current study, we investigate the function and mechanisms of Neuropilin-1 (NRP1), the co-receptor for vascular endothelial growth factor, in BC pathogenesis and progression. Methods The expression of NRP1 was assessed in several BC cell lines. Additionally, the biological function of NRP1 in proliferation, apoptosis, angiogenesis, migration, and invasion of BC were validated in vitro by silencing NRP1. Moreover, gene expression profiling chip analysis was conducted, and the related signalling pathways were confirmed by Western blot to reveal the potential molecular mechanisms by which NRP1 promotes the malignant progression of BC. Results Overexpression of NRP1 was observed in several human BC cell lines. NRP1 knockdown inhibited cell proliferation, promoted apoptosis, and decreased angiogenesis, migration, and invasion in T24 and 5637 human BC cells. Microarray analysis results indicated that the expression of NRP1 was correlated with the levels of cyclin dependent kinase (CDK) 4, baculoviral IAP repeat containing 3, Cyclin E 2, CDK2, and AP-1 transcription factor subunit in BC. We also demonstrated that the biological function of NRP1was associated with activation of the mitogen-activated protein kinase (MAPK) signalling pathway. Conclusions Our findings provide evidence that NRP1, as a potential tumour promoter, contributes to the metastasis and invasion of BC, which is associated with the activation of the MAPK pathway. Targeting NRP1 has the potential to become a new therapeutic strategy to benefit more patients with BC or other cancers.

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“…Il s'agit de la neuropiline-1 (NRP-1 ou BDCA4 [blood dendritic cell antigen 4], CD304 ou VEGF165R [vascular endothelial growth factor isoform 165 receptor]). Son expression in vivo est limitée aux lymphocytes T activés, aux cellules dendritiques, aux cellules endothéliales ainsi qu'à certaines cellules tumorales [12]. NRP-1 est en effet exprimée dans la très grande majorité des cellules transformées, dont les lignées de laboratoires [13], ce qui corrèle avec le tropisme de HTLV-1 in vitro.…”

Section: Trois Molécules Impliquées Dans L'entrée Viraleunclassified