2024
DOI: 10.1248/bpb.b23-00630
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NRP1 Induces Enhanced Stemness and Chemoresistance in Glioma Cells <i>via</i> YAP

Liang Jin,
Ai Jin,
Ling Wang
et al.

Abstract: Neuropilin-1 (NRP1), a transmembrane glycoprotein, plays an important role in the malignant progression of gliomas; however, its role in chemoresistance is not fully understood. In this study, we observed the effects of NRP1 on the stemness and chemoresistance of glioma cells and the mediating role of Yes-associated protein (YAP). We constructed NRP1 overexpressing LN-229 glioma cells. Cells were treated with recombinant NRP1 protein (rNRP1) and the YAP inhibitor Super-TDU when necessary. 3-(4,5-Dimethylthiazo… Show more

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