NSAID naproxen in mesoporous matrix MCM-41: drug uptake and release properties

Halamová, Dáša; Zeleňák, Vladimı́r

doi:10.1007/s10847-011-9990-x

Cited by 32 publications

(22 citation statements)

References 34 publications

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“…66 For example, surfactants such as hexadecyltrimethylammonium bromide (C 16 TAB) and dodecyltrimethylammonium bromide (C 12 TAB) are important in controlling pore size, particle morphology and thus loading dose. 61,64,99 The longer chain length of C 16 TAB used in MCM-41 increased pore size and released high dose of therapeutic agent, ibuprofen (68%), than shorter chain length of C 12 TAB, which only released 55% of ibuprofen. 66 Similarly, the addition of surfactant, N -cetyltrimethylammonium bromide (CTAB), prolonged the release of cancer agents, which enhanced the effects of cytotoxicity.…”

Section: Currently Available Drug Delivery Systemsmentioning

confidence: 99%

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Silica-based mesoporous nanoparticles for controlled drug delivery

et al. 2013

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Drug molecules with lack of specificity and solubility lead patients to take high doses of the drug to achieve sufficient therapeutic effects. This is a leading cause of adverse drug reactions, particularly for drugs with narrow therapeutic window or cytotoxic chemotherapeutics. To address these problems, there are various functional biocompatible drug carriers available in the market, which can deliver therapeutic agents to the target site in a controlled manner. Among the carriers developed thus far, mesoporous materials emerged as a promising candidate that can deliver a variety of drug molecules in a controllable and sustainable manner. In particular, mesoporous silica nanoparticles are widely used as a delivery reagent because silica possesses favourable chemical properties, thermal stability and biocompatibility. Currently, sol-gel-derived mesoporous silica nanoparticles in soft conditions are of main interest due to simplicity in production and modification and the capacity to maintain function of bioactive agents. The unique mesoporous structure of silica facilitates effective loading of drugs and their subsequent controlled release. The properties of mesopores, including pore size and porosity as well as the surface properties, can be altered depending on additives used to fabricate mesoporous silica nanoparticles. Active surface enables functionalisation to modify surface properties and link therapeutic molecules. The tuneable mesopore structure and modifiable surface of mesoporous silica nanoparticle allow incorporation of various classes of drug molecules and controlled delivery to the target sites. This review aims to present the state of knowledge of currently available drug delivery system and identify properties of an ideal drug carrier for specific application, focusing on mesoporous silica nanoparticles.

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Section: Currently Available Drug Delivery Systemsmentioning

confidence: 99%

“…In addition, due to the additional interaction between amine group and naproxen, sustained release of naproxen was observed in amine-modified MCM-41. 99 …”

Section: Currently Available Drug Delivery Systemsmentioning

confidence: 99%

Silica-based mesoporous nanoparticles for controlled drug delivery

et al. 2013

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“…However, the drug release rate is comparable and studies show that the drug release rate is within the range of reported results in other articles. The amounts of the released naproxen from amine‐modified and native MCM‐41 mesoporous silica were 90 and 95% of naproxen after 72 h . Naproxen release from chitosan/carbon nanotube nanocomposite hydrogel reached at 50–60% after 72 h at pH 7.4…”

Section: Resultsmentioning

confidence: 99%

In situsynthesized chitosan–gelatin/ZnO nanocomposite scaffold with drug delivery properties: Higher antibacterial and lower cytotoxicity effects

Rakhshaei

Namazi

Hamishehkar

et al. 2019

J of Applied Polymer Sci

108

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In this work, chitosan–gelatin/zinc oxide nanocomposite hydrogel scaffolds (CS–GEL/nZnO) were prepared via in situ synthesis of ZnO nanoparticles (nZnO) to reach a scaffold with both inherent antibacterial and drug delivery properties. The prepared nanocomposite hydrogel scaffolds were characterized using scanning electron microscopy, transmission electron microscopy, atomic absorption spectrometer, Fourier transform infrared spectroscopy, and X‐ray diffraction. In addition, swelling, biodegradation, antibacterial, cytocompatibility, and cell attachment of the scaffolds were evaluated. The results showed that the prepared scaffolds had high porosity with a pore size of 50–400 μm and nZnO were well distributed without any agglomeration on the CS–GEL matrix. In addition, the nanocomposite scaffolds showed enhanced swelling, biodegradation, and antibacterial properties. Moreover, the drug delivery studies using naproxen showed that nZnO could control naproxen release. Cytocompatibility of the samples was proved using normal human dermal fibroblast cells (HFF2). In comparison to the previous reports which nZnO were simply added to the matrix of the scaffold, in situ synthesis of nZnO was led to higher antibacterial and lower cytotoxicity effects as a result of well distribution of nZnO in this method. According to the findings, the in situ synthesized CS–GEL/nZnO is strongly recommended for biomedical applications especially skin tissue engineering. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47590.

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“…MCM-41 and SBA-15 are two common mesoporous silica materials, which have different pore sizes, including 2-5 nm and 5-10 nm, respectively. The smaller pore size helps to slow drug release and provides higher stability in mesoporous silica NPs [98,97,92]. In addition, the surface functionalization of silica NPs with different molecules allows developing silica NPs with various surface properties [96,99].…”

Section: Mesoporous Silica Nanoparticles (Msn)mentioning

confidence: 99%

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

et al. 2015

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The selective and efficient drug delivery to tumor cells can remarkably improve different cancer therapeutic approaches. There are several nanoparticles (NPs) which can act as a potent drug carrier for cancer therapy. However, the specific drug delivery to cancer cells is an important issue which should be considered before designing new NPs for in vivo application. It has been shown that cancer cells over-express folate receptor (FR) in order to improve their growth. As normal cells express a significantly lower levels of FR compared to tumor cells, it seems that folate molecules can be used as potent targeting moieties in different nanocarrier-based therapeutic approaches. Moreover, there is evidence which implies folate-conjugated NPs can selectively deliver anti-tumor drugs into cancer cells both in vitro and in vivo. In this review, we will discuss about the efficiency of different folate-conjugated NPs in cancer therapy.

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NSAID naproxen in mesoporous matrix MCM-41: drug uptake and release properties

Cited by 32 publications

References 34 publications

Silica-based mesoporous nanoparticles for controlled drug delivery

Silica-based mesoporous nanoparticles for controlled drug delivery

In situsynthesized chitosan–gelatin/ZnO nanocomposite scaffold with drug delivery properties: Higher antibacterial and lower cytotoxicity effects

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

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