Nuclear factor Y is a pervasive regulator of neuronal gene expression

Moreira, Pedro; Papatheodorou, Paul; Deng, Shuer; Gopal, Sandeep; Handley, Ava; Powell, David R.; Pocock, Roger

doi:10.1016/j.celrep.2023.113582

Cell Reports

2023

DOI: 10.1016/j.celrep.2023.113582

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Nuclear factor Y is a pervasive regulator of neuronal gene expression

Pedro Moreira,

Paul Papatheodorou,

Shuer Deng

et al.

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2024

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Cited by 3 publications

References 58 publications

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The role(s) of NF-Y in development and differentiation

Dolfini,

Imbriano,

Mantovani

2024

Cell Death Differ

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NF-Y is a conserved sequence-specific trimeric Transcription Factor -TF- binding to the CCAAT element. We review here the role(s) in development, from pre-implantation embryo to terminally differentiated tissues, by rationalizing and commenting on genetic, genomic, epigenetic and biochemical studies. This effort brings to light the impact of NF-YA isoforms on stemness and differentiation, as well as binding to distal vs promoter proximal sites and connections with selected TFs.

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The role(s) of NF-Y in development and differentiation

Dolfini,

Imbriano,

Mantovani

2024

Cell Death Differ

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Nuclear factor Y, a key player in neuronal gene regulation

Moreira,

Pocock

2024

Science Progress

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Establishing a functional nervous system is a complex process requiring tightly controlled gene expression programs to achieve the correct differentiation of distinct neuronal subtypes. The molecular programs required for neurons to acquire neuron-type-specific, and core pan-neuronal features mostly rely on sequence-specific transcription factors (TFs), which recognize and bind to cis-regulatory motifs present in the promoters of target genes. Recently, we investigated the role and mode of action of the NF-Y complex, a ubiquitously expressed transcriptional master regulator, in the Caenorhabditis elegans nervous system. We found that NFYA-1 is a pervasive regulator of neuron-specific and pan-neuronal gene batteries that are essential for neuronal development and function. Furthermore, we concluded that NFYA-1 acts cell autonomously by either directly binding to conserved motifs in target gene promoter regions or indirectly by regulating other transcriptional regulators to fine-tune gene expression. However, further studies are required to fully define the impact of the NF-Y complex on nervous system regulatory networks and how NF-Y coordinates with other TFs in this regard.

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Functions of nuclear factor Y in nervous system development, function and health

Moreira,

Pocock

2024

Neural Regeneration Research

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Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes, one of the most common motifs found in gene promoters and enhancers. Over the last 30 years, research has revealed that the nuclear factor Y complex controls many aspects of brain development, including differentiation, axon guidance, homeostasis, disease, and most recently regeneration. However, a complete understanding of transcriptional regulatory networks, including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains elusive. In this review, we explore the nuclear factor Y complex’s role and mode of action during brain development, as well as how genomic technologies may expand understanding of this key regulator of gene expression.

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Nuclear factor Y is a pervasive regulator of neuronal gene expression

Cited by 3 publications

References 58 publications

The role(s) of NF-Y in development and differentiation

The role(s) of NF-Y in development and differentiation

Nuclear factor Y, a key player in neuronal gene regulation

Functions of nuclear factor Y in nervous system development, function and health

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