Nuclear fermidynamics and T. D.−S−H. F.

Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.

“…Several lines ofevidence suggest that it does. Fust, protein C levels decrease after E. coil infusion, and since when we block protein C activation, this decrease is also blocked, it appears that in this animal model the decrease is due to protein C activation and not inhibition of synthesis, as has been suggested in patient studies (23)(24)(25). Second, when protein C activation is blocked, the concentration of E. coli required to elicit a lethal response is reduced at least 10-fold.…”

Detection of protein C activation in humans.

“…Human protein C is a vitamin K-dependent glycoprotein of molecular weight -62,000 that circulates in plasma as an inactive zymogen at a concentration of -4 sg/ml (1,2). This component consists of a heavy chain and a light chain, which are joined by a single disulfide bridge (1).…”

Pituitary hormones influence polyphosphoinositide metabolism in rat brain

“…A similar loss of labelled phosphate from TPI and DPI was found in response to influx of Ca2+ into synaptosomes [4]. A relation has been suggested between the enhanced turnover of TPI and DPI, the PI effect and processes dependent on the influx of Ca2+ into the cell [ 1,2].…”

“…In contrast to the low quantities of DPI and TPI in membranes from a variety of cell types, brain cell plasma membranes contain appreciable amounts of these polyphosphoinositides [3]. It appears that they play a role in the Ca2+ influx into the cell [ 1,2,4].…”