Nuclear magnetic resonance lipoprotein abnormalities in newly-diagnosed type 2 diabetes and their association with preclinical carotid atherosclerosis

Amor, Antonio J.; Catalan, Marta; Pérez, Antonio; Herreras, Zoe; Pinyol, Montserrat; Sala‐Vila, Aleix; Cofán, Montserrat; Gilabert, Rosa; Ros, Emilio; Ortega, Emilio

doi:10.1016/j.atherosclerosis.2016.02.014

Cited by 38 publications

(24 citation statements)

References 39 publications

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“…Insulin resistance is strongly associated with several lipoprotein profile derangements [ 34 ]. Previous NMR studies performed in non-diabetic and type 2 diabetes mellitus patients have shown that either markers of adiposity or several non-invasive scores of fatty liver disease (both closely related with insulin resistance) were directly associated with VLDL-related variables, and inversely with HDL-related variables [ 27 , 28 ]. In our study, the adiposity marker most closely associated with insulin resistance (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, analysis of covariance (ANCOVA) was used for adjusting these differences by age, sex and lipid-lowering drugs (model 1), and additionally by BMI and leukocyte count (model 2). The variables included in the models were selected according to the prior knowledge [ 27 , 28 ], or after evaluating the significative correlations with NRM-lipoproteins found in our sample of participants. Further between-group differences in NMR-lipoprotein variables were performed only in participants without lipid-lowering drugs, or according to gender, smoking habit or chronic diabetic complications (i.e., diabetic nephropathy and retinopathy).…”

Section: Methodsmentioning

confidence: 99%

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Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles

Amor

Castelblanco

Hernández

et al. 2020

Cardiovasc Diabetol

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Background: Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profile in T1DM individuals, and analysed differences with non-diabetic counterparts. Methods: This cross-sectional study involved 508 adults with T1DM and 347 controls, recruited from institutions in a Mediterranean region of Spain. Conventional and advanced (assessed by nuclear magnetic resonance [NMR] spectroscopy) lipoprotein profiles were analysed. Crude and adjusted (by age, sex, statin use, body mass index and leukocyte count) comparisons were performed. Results: The median (interquartile range) age of the study participants was 45 (38-53) years, 48.2% were men. In the T1DM group, the median diabetes duration was 23 (16-31) years, and 8.1% and 40.2% of individuals had nephropathy and retinopathy, respectively. The proportion of participants with hypertension (29.5 vs. 9.2%), and statin use (45.7% vs. 8.1%) was higher in the T1DM vs. controls (p < 0.001). The T1DM group had a better conventional (all parameters, p < 0.001) and NMR-lipid profile than the control group. Thus, T1DM individuals showed lower concentrations of atherogenic lipoproteins (VLDL-particles and LDL-particles) and higher concentrations of anti-atherogenic lipoproteins (HDL-particles) vs. controls, even after adjusting for several confounders (p < 0.001 for all). While non-diabetic women had a more favourable lipid profile than non-diabetic men, women with T1DM had a similar concentration of LDL-particles compared to men with T1DM (1231 [1125-1383] vs. 1257 [1128-1383] nmol/L, p = 0.849), and a similar concentration of small-LDL-particles to non-diabetic women (672.8 [614.2-733.9] vs. 671.2 [593.5-761.4] nmol/L, respectively; p = 0.790). Finally, T1DM individuals showed higher discrepancies between NMR-LDL-particles and conventional LDLcholesterol than non-diabetic subjects (prevalence of LDL-cholesterol < 100 mg/dL & LDL-particles > 1000 nmol/L: 38 vs. 21.2%; p < 0.001). All these differences were largely unchanged in participants without lipid-lowering drugs (T1DM, n = 275; controls, n = 317).

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles

Amor

Castelblanco

Hernández

et al. 2020

Cardiovasc Diabetol

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“…Patients with diabetes have shown enhanced blood lipid profiles due to increased mobilization of FFAs from fat depots (Amor et al. 2016 ). Moreover, a study demonstrated that higher FFA levels are a cardiovascular risk factor in patients with diabetes.…”

Section: Discussionmentioning

confidence: 99%

Galangin, a dietary flavonoid, ameliorates hyperglycaemia and lipid abnormalities in rats with streptozotocin-induced hyperglycaemia

Aloud

Veeramani

Govindasamy

et al. 2018

Pharmaceutical Biology

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Context: Galangin, a natural flavonoid, is found in honey and Alpinia officinarum Hance (Zingiberaceae). Galangin has antiviral, antimicrobial, antidiabetic and anticancer properties, without side effects. The effects of galangin on hyperglycaemia and lipid abnormalities are not known.Objective: To elucidate the effectiveness of galangin on hyperglycaemia-associated complications and lipid changes in rats with streptozotocin (STZ)-induced hyperglycaemia.Materials and methods: Diabetes was induced in adult Wistar rats by administering 40 mg/kg of STZ. In our previous study, galangin had no toxicity at concentrations up to 320 mg/kg. Therefore three doses of galangin (4, 8 or 16 mg/kg BW) or glibenclamide (600 µg/kg BW) were administered daily to diabetic rats orally for 45 days.Results: Diabetic rats showed a significant (p < 0.05) increased levels of plasma glucose (281.10 mg/dL) and decreased levels of insulin (6.01 μU/mL). Additionally, diabetic rats showed a significant (p < 0.05) increased levels of plasma lipid profiles such as total cholesterol (149.05 mg/dL), triglycerides (143.28 mg/dL), free fatty acids (139.37 mg/dL), phospholipids (127.53 mg/dL), plasma low-density lipoprotein-cholesterol (98.72 mg/dL), plasma very low-density lipoprotein-cholesterol (28.65 mg/dL), and significant (p < 0.05) decreased in plasma high-density lipoprotein-cholesterol (21.68 mg/dL). When galangin was administered to the hyperglycaemic rats, plasma glucose and insulin levels and lipid profiles reverted to levels similar to those in healthy control rats.Discussion and conclusions: Administration of galangin reduced hyperlipidaemia related to the risk of diabetic complications and could be beneficial for diabetic hyperlipidaemic patients. Further work detailing its mechanism-of-action for improving hyperglycaemic-associated lipid abnormalities is needed.

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“…The VLDL 3 , which is the smallest and densest VLDL subfraction, has been previously associated with the presence of subclinical atherosclerosis particularly in diabetics, and might be associated with higher CVD risk (24)(25)(26). VLDL is fractioned into remnant VLDL particles (VLDL 3 ) and IDL, which contains proportionally less triglycerides but more cholesterol than larger, less dense VLDL, and, consequently, is implicated in atherogenesis due to its direct deposition into the sub-intimal space in the arterial wall (27,28). Significantly, no previous study has reported the association between VLDL 3 -C and migraine headache.…”

Section: Discussionmentioning

confidence: 99%

The relationship between migraine and lipid sub-fractions among individuals without cardiovascular disease: A cross-sectional evaluation in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

et al. 2017

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Introduction Recent studies have explored the relationship between dyslipidemia and migraine in a cardiovascular context. Thus, we aimed to evaluate the possible association between lipids, lipoprotein subfractions and migraine according to aura symptoms in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods 1,560 women and 1,595 men, without CVD or lipid disorders requiring medication, underwent a baseline clinical assessment. Total-cholesterol and its sub-fractions (LDL, VLDL and HDL subclass cholesterol); triglycerides and triglyceride-rich lipoprotein cholesterol [TRL-C (VLDL-C VLDL-C + IDL-C)] were determined by vertical auto profile (VAP). We also calculated logarithmic LDL density ratio [LLDR = ln ((LDL-C + LDL-C)/(LDL-C + LDL-C))], T-Chol/HDL-C and triglycerides/HDL-C ratios. Odds ratios (OR) with 95% confidence intervals (CI) were obtained to evaluate the relationship between lipids tertiles and migraine for both sexes. Results Main findings revealed positive associations between migraine without aura (MO) and the highest tertiles of VLDL-C (OR, 1.61; 95%CI, 1.07-2.40) and TRL-C (OR, 1.55; 95% CI, 1.03-2.34) in women. In men, the highest tertile of VLDL-C (OR, 3.87; 95%CI, 1.23-12.19) was positively associated with MO, as well. Conclusions In middle-aged participants without CVD or lipid disorders requiring medication, the worst lipid profile was determined by the highest levels of TRL-C and their cholesterol-rich remnants in migraineurs without aura for both sexes.

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Nuclear magnetic resonance lipoprotein abnormalities in newly-diagnosed type 2 diabetes and their association with preclinical carotid atherosclerosis

Cited by 38 publications

References 39 publications

Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles

Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles

Galangin, a dietary flavonoid, ameliorates hyperglycaemia and lipid abnormalities in rats with streptozotocin-induced hyperglycaemia

The relationship between migraine and lipid sub-fractions among individuals without cardiovascular disease: A cross-sectional evaluation in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

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