Nuclear Peroxiredoxine: A promising Target for Drug & Diagnostic Solutions of Malaria

Abstract

During development inside the erythrocytes, malaria parasites plasmodium have to face constant attack of oxidative stress build up by reactive oxygen and nitrogen species produced exogenously & endogenously. Plasmodium utilizes a unique antioxidant defense system for their survival against this oxidative attack. A recent report has characterized an unusual nuclear peroxiredoxine in Plasmodium falciparum, PfnPrx that has a broad specificity of substrate and having the ability to reduce peroxides from simple to complex one. Study revealed its association with chromatin of the parasite in genome wide manner which suggests an essential role in protection of nuclear DNA and expression throughout the erythrocytic stage. This mini review will discuss about the possibilities of P. falciparum nuclear peroxiredoxine as a potential target for drug discovery and development of diagnostic products of Malaria.