We study the structure factors for spin-independent WIMP scattering off xenon based on state-ofthe-art large-scale shell-model calculations, which are shown to yield a good spectroscopic description of all experimentally relevant isotopes. Our results are based on the leading scalar one-body currents only. At this level and for the momentum transfers relevant to direct dark matter detection, the structure factors are in very good agreement with the phenomenological Helm form factors used to give experimental limits for WIMP-nucleon cross sections. In contrast to spin-dependent WIMP scattering, the spin-independent channel, at the one-body level, is less sensitive to nuclear structure details. In addition, we explicitly show that the structure factors for inelastic scattering are suppressed by ∼ 10 −4 compared to the coherent elastic scattering response. This implies that the detection of inelastic scattering will be able to discriminate clearly between spin-independent and spin-dependent scattering. Finally, we provide fits for all calculated structure factors.