Nucleophilic Aliphatic Substitution

Synthesis and in vitro antimicrobial activity evaluation of coumarin-3-carboxylic acids obtained via cascade reaction using chitosan as a recyclable catalyst

“…This result is in agreement with the literature, which demonstrates that more dilute systems favor cyclization reactions. 28 The synthesis of 3a is strongly influenced by the thermodynamic factor, in the same conditions, but in the absence of heating, the reaction is five times slower (entry 6, Table 1).…”