Nucleoporin 107 is a prognostic biomarker in hepatocellular carcinoma associated with immune infiltration

Nong, Ju‐sen; Zhou, Xin; Liu, Jun‐qi; Luo, Jianzhu; Huang, Jiami; Xie, Haixiang; Yang, Ke‐jian; Wang, Jing; Ye, Xin‐ping; Peng, Tao

doi:10.1002/cam4.5807

Cited by 8 publications

(3 citation statements)

References 74 publications

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“…Chemokines are a class of small molecule cytokines that can specifically recruit immune cells and play an important role in the immunotherapy of gliomas ( Nong et al, 2023 ). Chemokines can promote the directional migration and aggregation of various immune effector cells to tumor tissues ( Do et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Unveiling the landscape of cytokine research in glioma immunotherapy: a scientometrics analysis

Zhang,

Chen,

Jiang

et al. 2024

Front. Pharmacol.

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Background: Cytokines modulate the glioma tumor microenvironment, influencing occurrence, progression, and treatment response. Strategic cytokine application may improve glioma immunotherapy outcomes. Gliomas remain refractory to standard therapeutic modalities, but immunotherapy shows promise given the integral immunomodulatory roles of cytokines. However, systematic evaluation of cytokine glioma immunotherapy research is absent. Bibliometric mapping of the research landscape, recognition of impactful contributions, and elucidation of evolutive trajectories and hot topics has yet to occur, potentially guiding future efforts. Here, we analyzed the structure, evolution, trends, and hotspots of the cytokine glioma immunotherapy research field, subsequently focusing on avenues for future investigation.Methods: This investigation conducted comprehensive bibliometric analyses on a corpus of 1529 English-language publications, from 1 January 2000, to 4 October 2023, extracted from the Web of Science database. The study employed tools including Microsoft Excel, Origin, VOSviewer, CiteSpace, and the Bibliometrix R package, to systematically assess trends in publication, contributions from various countries, institutions, authors, and journals, as well as to examine literature co-citation and keyword distributions within the domain of cytokines for glioma immunotherapy. The application of these methodologies facilitated a detailed exploration of the hotspots, the underlying knowledge structure, and the developments in the field of cytokines for glioma immunotherapy.Results: This bibliometric analysis revealed an exponential growth in annual publications, with the United States, China, and Germany as top contributors. Reviews constituted 17% and research articles 83% of total publications. Analysis of keywords like “interleukin-13,” “TGF-beta,” and “dendritic cells” indicated progression from foundational cytokine therapies to sophisticated understanding of the tumor microenvironment and immune dynamics. Key research avenues encompassed the tumor microenvironment, epidermal growth factor receptor, clinical trials, and interleukin pathways. This comprehensive quantitative mapping of the glioma immunotherapy cytokine literature provides valuable insights to advance future research and therapeutic development.Conclusion: This study has identified remaining knowledge gaps regarding the role of cytokines in glioma immunotherapy. Future research will likely focus on the tumor microenvironment, cancer vaccines, epidermal growth factor receptor, and interleukin-13 receptor alpha 2. Glioma immunotherapy development will continue through investigations into resistance mechanisms, microglia and macrophage biology, and interactions within the complex tumor microenvironment.

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Section: Discussionmentioning

confidence: 99%

Unveiling the landscape of cytokine research in glioma immunotherapy: a scientometrics analysis

Zhang,

Chen,

Jiang

et al. 2024

Front. Pharmacol.

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“…The former samples were used to evaluate the diagnostic value and prognostic significance of SART3 in HCC, while the latter were subjected to next-generation sequencing (NGS) at GENETRON (Beijing, China) or REXPLO (Nanning, China) to examine the correlation between SART3 and TP53 mutations. The immunohistochemical techniques employed in this study were based on previous research [ 22 ]. Two independent pathologists evaluated and scored the immunohistochemical staining.…”

Section: Methodsmentioning

confidence: 99%

SART3, regulated by p53, is a biomarker for diagnosis, prognosis and immune infiltration in hepatocellular carcinoma

Nong,

Yang,

et al. 2023

Aging

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Objective: This study aimed to investigate the role of squamous cell carcinoma antigen recognized by T cells 3 (SART3) in hepatocellular carcinoma (HCC). Methods: SART3 expression and prognostic value were analyzed in TCGA and GEO datasets. The diagnostic value and prognostic significance of SART3 were determined using immunohistochemistry in the Guangxi cohort. The whole-exome mutation spectrum of SART3 was analyzed in high and low expression groups in both TCGA and Guangxi cohorts. The biological functions of the SART3 gene were validated through in vitro experiments using small interfering RNA technology to downregulate SART3 expression in HCC cell lines. Results: SART3 expression was significantly higher in HCC tissues than in adjacent noncancerous liver tissues in TCGA, GEO and Guangxi cohorts. High expression of SART3 was significantly associated with poor prognosis in HCC patients. In TCGA and Guangxi cohorts, the expression of SART3 in the TP53 mutation group was significantly higher than that in the non-mutation group. Downregulation of SART3 expression significantly inhibited the migration and proliferation of HCC cells. SART3 may be involved mainly in immune infiltration of Th2 cells and macrophages in HCC. Additionally, SART3 can upregulate the expression of immune checkpoints (PD-L1 and TIM-3) and predict potential therapeutic agents for HCC. Conclusion: The findings of this study demonstrate the diagnostic and prognostic value of SART3 in HCC. SART3 may be associated with immune infiltration of Th2 cells and macrophages in HCC, highlighting its potential role in the development and progression of HCC.

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“…4 NUP107 not only comes into play in the development of many types of cancer, it is also involved in the construction of nuclear pore complex. 5,6 Regulating nucleocytoplasmic transport and chromatin organization is a crucial role of the nuclear pore complex, which may control the biological properties of cancer and influence the therapeutic effect of cancer. 7 Tumor immunotherapy and immune infiltration are the focus of cancer research and have wide clinical application in LUAD.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Nucleoporin 107 Overexpression and Its Association with Prognosis and Immune Infiltration in Lung Adenocarcinoma by Bioinformatics Methods

Li,

Zhu

et al. 2023

IJGM

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Background: Lung adenocarcinoma (LUAD) has high morbidity and mortality. Current studies indicate nucleoporin 107 (NUP107) is involved in the construction of nuclear pore complex, and NUP107 overexpression contributes to the growth and development in most types of cancers, but its effect in LUAD has not been elucidated. Methods: Differences in NUP107 expression were investigated using the Cancer Genome Atlas (TCGA) and multiple Gene Expression Omnibus (GEO) data sets. Enrichment analysis were implemented to probe the NUP107 function. The association of NUP107 with the degree of immune cell infiltration was investigated by the TIMER database, single-sample gene set enrichment analysis (ssGSEA), and ESTIMATE. The association of NUP107 expression with tumor mutation burden (TMB), TP53, and immune checkpoint was analyzed. Single-cell RNA sequencing data were used to detect NUP107 expression in different cell clusters. Finally, we performed real-time quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry (IHC) to prove the difference of NUP107 expression. Results: NUP107 was overexpressed in LUAD and mainly expressed in cancer stem cell (CSC). Overexpression of NUP107 in LUAD suggested a poorer prognosis. Functional enrichment analysis pointed out that NUP107 was mainly linked to the regulation of cell cycle. Both immune cell infiltration and TMB were found to be in connection with NUP107. Cases in the group with high NUP107 expression had poorer immune infiltration, but had higher expression of immune checkpoints, TMB, and proportion of TP53 mutations. Conclusion: NUP107 is a sensitive diagnostic and prognostic factor for LUAD and may be involved in tumor progression through its effects on cell cycle and immune infiltration.

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Nucleoporin 107 is a prognostic biomarker in hepatocellular carcinoma associated with immune infiltration

Cited by 8 publications

References 74 publications

Unveiling the landscape of cytokine research in glioma immunotherapy: a scientometrics analysis

Unveiling the landscape of cytokine research in glioma immunotherapy: a scientometrics analysis

SART3, regulated by p53, is a biomarker for diagnosis, prognosis and immune infiltration in hepatocellular carcinoma

Analysis of Nucleoporin 107 Overexpression and Its Association with Prognosis and Immune Infiltration in Lung Adenocarcinoma by Bioinformatics Methods

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