Nucleotide Sequence Variation in the Insulin-Like Growth Factor 1 Gene Affects Growth and Carcass Traits in New Zealand Romney Sheep

Li, Shaobin; Zhou, Huitong; Zhao, Fangfang; Qian, Fang; Wang, Jiqing; Liu, Xiu; Luo, Yuzhu; Hickford, Jonathan G. H.

doi:10.1089/dna.2020.6166

Cited by 7 publications

(5 citation statements)

References 28 publications

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“…The same gene with two SNPs in the intron region was also identified by Yuan et al (2012) in sheep in addition to observations in cattle (Chen et al, 2018). IGF1 gene polymorphisms have been reported consistently in three studies (Grochowska et al, 2021;Li et al, 2021;Meira et al, 2019) in concordance with reports in other species such as cattle (Yang, Zhu, et al, 2022), pigs (Bouquet et al, 2021), and fish (Chandhini et al, 2021) suggesting IGF1 to be a possible marker of growth and FE. Polymorphisms in the intron region of IGF1 was found to be associated with carcass traits such as length of carcass and rib yield (Meira et al, 2019).…”

Section: Other Putative Omics Markers Of Fe Carcass and Meat Quality ...supporting

confidence: 78%

“…Two IGF1 genotypes namely A 2 and B 2 were detected by Li et al. ( 2021 ) where A 2 was associated with increased HCW and B 2 with decreased HCW. Furthermore, SNPs in the MEF2B and IGF1 genes had connections with indices of meat quality and were reported to be employed as markers for meat quality in sheep (Trukhachev, Belyaev, et al., 2016 ; Yang et al., 2014 ).…”

Section: Resultsmentioning

confidence: 94%

“…Two other studies report SNPs in the intron 1 region to have associations with sheep body weight (Trukhachev, Skripkin, et al, 2016) and carcass traits (Su et al, 2014). Two IGF1 genotypes namely A 2 and B 2 were detected by Li et al (2021) where A 2 was associated with increased HCW and B 2 with decreased HCW. Furthermore, SNPs in the MEF2B and IGF1 genes had connections with indices of meat quality and were reported to be employed as markers for meat quality in sheep (Trukhachev, Belyaev, et al, 2016;Yang et al, 2014).…”

Section: Other Putative Omics Markers Of Fe Carcass and Meat Quality ...mentioning

confidence: 93%

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Insights into the influence of diet and genetics on feed efficiency and meat production in sheep

Chacko Kaitholil,

Mooney,

Aubry

et al. 2023

Animal Genetics

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Feed costs and carcass yields affect the profitability and sustainability of sheep production. Therefore, it is crucial to select animals with a higher feed efficiency and high‐quality meat production. This study focuses on the impact of dietary and genetic factors on production traits such as feed efficiency, carcass quality, and meat quality. Diets promote optimal sheep growth and development and provide sufficient protein can lead to higher‐quality meat. However, establishing an optimized production system requires careful consideration and balance of dietary parameters. This includes ensuring adequate protein intake and feeding diets with higher intestinal absorption rates to enhance nutrient absorption in the gut. The study identifies specific genes, such as Callipyge, Calpastatin, and Myostatin, and the presence of causal mutations in these genes, as factors influencing animal growth rates, feed efficiency, and meat fatty acid profiles. Additionally, variants of other reported genes, including PIGY, UCP1, MEF2B, TNNC2, FABP4, SCD, FASN, ADCY8, ME1, CA1, GLIS1, IL1RAPL1, SOX5, SOX6, and IGF1, show potential as markers for sheep selection. A meta‐analysis of reported heritability estimates reveals that residual feed intake (0.27 ± 0.07), hot carcass weight (0.26 ± 0.05), dressing percentage (0.23 ± 0.05), and intramuscular fat content (0.45 ± 0.04) are moderately to highly heritable traits. This suggests that these traits are less influenced by environmental factors and could be improved through genetic selection. Additionally, positive genetic correlations exist between body weight and hot carcass weight (0.91 ± 0.06), dressing percentage (0.35 ± 0.15), and shear force (0.27 ± 0.24), indicating that selecting for higher body weight could lead to favorable changes in carcass quality, and meat quality.

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Section: Other Putative Omics Markers Of Fe Carcass and Meat Quality ...supporting

confidence: 78%

Section: Resultsmentioning

confidence: 94%

Section: Other Putative Omics Markers Of Fe Carcass and Meat Quality ...mentioning

confidence: 93%

See 1 more Smart Citation

Insights into the influence of diet and genetics on feed efficiency and meat production in sheep

Chacko Kaitholil,

Mooney,

Aubry

et al. 2023

Animal Genetics

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show abstract

“…A response in sheep similar to that of TNFSF8 to IGF1 in cows could be of great interest for ewe lamb replacement selection. IGF1 is a well-accepted candidate gene impacting growth and development in sheep [ 50 , 51 ], in particular at nine months of age in Hulun Buir sheep [ 52 ]. The association between TNFSF8 function and live weight of ewe lambs at eight months of age is not clear and requires further research.…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Association Studies of Live Weight at First Breeding at Eight Months of Age and Pregnancy Status of Ewe Lambs

Haslin

Pettigrew²,

Kenyon

et al. 2023

Genes

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This study estimated genetic parameters and identified candidate genes associated with live weight, and the occurrence of pregnancy in 1327 Romney ewe lambs using genome-wide association studies. Phenotypic traits considered were the occurrence of pregnancy in ewe lambs and live weight at eight months of age. Genetic parameters were estimated, and genomic variation was assessed using 13,500 single-nucleotide polymorphic markers (SNPs). Ewe lamb live weight had medium genomic heritability and was positively genetically correlated with occurrence of pregnancy. This suggests that selection for heavier ewe lambs is possible and would likely improve the occurrence of pregnancy in ewe lambs. No SNPs were associated with the occurrence of pregnancy; however, three candidate genes were associated with ewe lamb live weight. Tenascin C (TNC), TNF superfamily member 8 (TNFSF8) and Collagen type XXVIII alpha 1 chain (COL28A1) are involved in extracellular matrix organization and regulation of cell fate in the immune system. TNC may be involved in ewe lamb growth, and therefore, could be of interest for selection of ewe lamb replacements. The association between ewe lamb live weight and TNFSF8 and COL28A1 is unclear. Further research is needed using a larger population to determine whether the genes identified can be used for genomic selection of replacement ewe lambs.

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“…Another study in Santa Ines sheep, showed SNPs in IGF1 intron 1 were found to be associated with many carcass traits including rump girth, internal carcass length, neck weight, and rib yield (Meira et al 2019). The study in 848 New Zealand Romney lambs using PCR-single strand conformation polymorphism (SSCP) analyses for nucleotide sequence variation in three regions of ovine IGF1 (part of the 5′ flanking region showed that polymorphism in exon 3 of ovine IGF1 has potential for use as a gene-marker for some carcass and growth traits (Li et al 2021). Furthermore, the association between IGF1 and IGF-1R genetic polymorphisms and growth traits in Hulun Buir sheep has been studied by Ning Ding et al (2022).…”

Section: G [254]mentioning

confidence: 99%

Identification of Boerka Goats Raised in Bali by using Molecular Analysis of IGF1 (Insulin-Like Growth Factor 1) Gene

2024

Int J Vet Sci

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The fulfillment of the lamb demand in Bali, Boerka goats was developed by the local government in 2019. Boerka goats resulting from a cross between male Boer breeds and female Kacang goats are categorized as meat goats and predicted to have good adaptation to unfavorable environments like the Kacang goats and have good meat quality like Boer goats as their parents. The study aims to analyze insulin-like growth factor 1 (IGF1) as a gene related to the growth of Boerka goats. A total of 16 Boerka goats from a group of livestock farmers in Sanda village were used as objects of study. The blood samples were taken in a venoject tube filled with EDTA anticoagulant. DNA total was extracted from each sample and subjected to PCR with IFG-1 gene target by using IGF677F 5'-ATTACAAAGCTGCCTGCCCC-'3 and IGF879R 5'-ACCTTACCCGTATGAAAGGAATATACGT-'3 primers. PCR products were then sequenced and analyzed with the MEGA 11 program. Results of the study showed the IFG-1 gene of Boerka goats compose of nucleotides dominated by adenine base guanine (22.3%), and pyrimidine tyrosine (33.9%). In conclusion, Boerka goats raised in Bali genetically share a clade with Ovis aries and Capra malabari with a bootstrap value is 99% as a type of meat and milk goats so that Boerka goats tend to have characteristics and appearance resembling Ovis aries and Capra malabari goats.

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Nucleotide Sequence Variation in the Insulin-Like Growth Factor 1 Gene Affects Growth and Carcass Traits in New Zealand Romney Sheep

Cited by 7 publications

References 28 publications

Insights into the influence of diet and genetics on feed efficiency and meat production in sheep

Insights into the influence of diet and genetics on feed efficiency and meat production in sheep

Genome-Wide Association Studies of Live Weight at First Breeding at Eight Months of Age and Pregnancy Status of Ewe Lambs

Identification of Boerka Goats Raised in Bali by using Molecular Analysis of IGF1 (Insulin-Like Growth Factor 1) Gene

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