Nucleus Accumbens Functional Connectivity with the Frontoparietal Network Predicts Subsequent Change in Body Mass Index for American Children

Assari, Shervin; Boyce, Shanika; Bazargan, Mohsen

doi:10.3390/brainsci10100703

Cited by 5 publications

(3 citation statements)

References 90 publications

(168 reference statements)

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“…NAc regulates motivated behaviors and intake and seeking reward, and response to cues related to food and drugs [81][82][83][84][85] . The Adolescent Brain Cognitive Development study (ABCD) 89 and other studies [81][82][83][84][85] show that data suggests that NAc changes predict disorders related to the reward [88][89][90][91][92][93][94] .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, research has established a correlation between NAc modifications and shifts in motivated behaviors, encompassing the regulation and pursuit of cues, food, drugs, addiction, and obesity [81][82][83][84][85] . Insights from research both external [81][82][83][84][85] and internal to the Adolescent Brain Cognitive Development (ABCD) study suggest the potential of NAc alterations as predictive markers for reward-related disorders in the future [88][89][90][91][92][93][94] .…”

Section: Introductionmentioning

confidence: 99%

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Sex Differences in the Relationship Between Nucleus Accumbens Volume and Youth Tobacco or Marijuana Use Following Stressful Life Events

Assari,

Sheikhattari

2024

J Ment Health Clin Psychol

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Background: Exposure to stressful life events (SLEs) can upset balance and affect the healthy brain development of children and youths. These events may influence substance use by altering brain reward systems, especially the nucleus accumbens (NAc), which plays a key role in motivated behaviors and reward processing. The interaction between sensitization to SLEs, depression, and substance use might vary between male and female youths, potentially due to differences in how each sex responds to SLEs. Aims: This study aims to examine the effect of sex on the relationship between SLEs, Nucleus Accumbens activity, and substance use in a nationwide sample of young individuals. Methods: We utilized data from the Adolescent Brain Cognitive Development study (ABCD), a longitudinal study of pre-adolescents aged 9–10 years, comprising 11,795 participants tracked over 36 months. Structured interviews measuring SLEs were conducted using the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS). Initial linear regression analyses explored if SLEs could predict volumes of the right and left NAc. Subsequently, Cox regression models were used to investigate how SLEs and NAc volume might predict the initiation of tobacco and marijuana use, with the analysis stratified by sex to address potential sex differences. Results: Our findings reveal that SLEs significantly predicted marijuana use in males but not in females, and tobacco use was influenced by SLEs in both sexes. A higher number of SLEs was linked with decreased left NAc volume in males, a trend not seen in females. The right NAc volume did not predict substance use in either sex. However, volumes of both the right and left NAc were significant predictors of future tobacco use, with varying relationships across sexes. In females, an inverse relationship was observed between both NAc volumes and the risk of tobacco use. In contrast, a positive correlation existed between the left NAc volume and tobacco and marijuana use in males, with no such relationship for females. Conclusion: This study underscores that the associations between SLEs, NAc volume, and subsequent substance use are influenced by a nuanced interplay of sex, brain hemisphere, and substance type.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sex Differences in the Relationship Between Nucleus Accumbens Volume and Youth Tobacco or Marijuana Use Following Stressful Life Events

Assari,

Sheikhattari

2024

J Ment Health Clin Psychol

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“…The authors discussed the results in the context of obesity and possibly unhealthy eating, although the percentage of obesity or presence of unhealthy eating could not be reported [122]. Another study of the same cohort of children evidenced that higher functional resting state connectivity between the nucleus accumbens and the frontoparietal network was predictive of BMI increase over time, although only for the female group [123]. In adolescents, one study in a community sample (n = 122) observed that those with BED symptoms (possibly a mixed sample sBED/BED), compared to those without, showed an increased reward-receipt response in the caudate in a reward-guessing task when money was won [95].…”

Section: Reward-based Deficitsmentioning

confidence: 99%

Binge-Eating Precursors in Children and Adolescents: Neurodevelopment, and the Potential Contribution of Ultra-Processed Foods

Via

Contreras‐Rodríguez

2023

Nutrients

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Binge-eating disorder (BED) is a highly prevalent disorder. Subthreshold BED conditions (sBED) are even more frequent in youth, but their significance regarding BED etiology and long-term prognosis is unclear. A better understanding of brain findings associated with BED and sBED, in the context of critical periods for neurodevelopment, is relevant to answer such questions. The present narrative review starts from the knowledge of the development of emotional self-regulation in youth, and the brain circuits supporting emotion-regulation and eating behaviour. Next, neuroimaging studies with sBED and BED samples will be reviewed, and their brain-circuitry overlap will be examined. Deficits in inhibition control systems are observed to precede, and hyperactivity of reward regions to characterize, sBED, with overlapping findings in BED. The imbalance between reward/inhibition systems, and the implication of interoception/homeostatic processing brain systems should be further examined. Recent knowledge of the potential impact that the high consumption of ultra-processed foods in paediatric samples may have on these sBED/BED-associated brain systems is then discussed. There is a need to identify, early on, those sBED individuals at risk of developing BED at neurodevelopmental stages when there is a great possibility of prevention. However, more neuroimaging studies with sBED/BED pediatric samples are needed.

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Investigating the brain network characteristics of multimodal emotion recognition and its classification applications based on functional connectivity patterns

Gu,

Luo,

Gong

et al. 2024

Biomedical Signal Processing and Control

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Nucleus Accumbens Functional Connectivity with the Frontoparietal Network Predicts Subsequent Change in Body Mass Index for American Children

Cited by 5 publications

References 90 publications

Sex Differences in the Relationship Between Nucleus Accumbens Volume and Youth Tobacco or Marijuana Use Following Stressful Life Events

Sex Differences in the Relationship Between Nucleus Accumbens Volume and Youth Tobacco or Marijuana Use Following Stressful Life Events

Binge-Eating Precursors in Children and Adolescents: Neurodevelopment, and the Potential Contribution of Ultra-Processed Foods

Investigating the brain network characteristics of multimodal emotion recognition and its classification applications based on functional connectivity patterns

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