Nucleus accumbens in the pathogenesis of major depressive disorder: A brief review

Yajie, Jiang; Zou, Manshu; Wang, Qianqian; Wang, Yuhong

doi:10.1016/j.brainresbull.2023.03.004

Cited by 11 publications

(3 citation statements)

References 140 publications

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“…The nucleus accumbens is part of the mesolimbic pathway. It is critical for motivated behaviors and reward processing and is thought to play a role in the pathogenesis of major depression ( 94 ) and addiction ( 95 ). While we did not observe differences between HUM1 and HUM2 animals in the post-hoc tests for sucrose preference, there was a main effect of microbiome inoculation group on sucrose preference with HUM1 animals being more similar to SPF animals and HUM2 showing lower preference for sucrose, albeit not as low as the GF animals.…”

Section: Discussionmentioning

confidence: 99%

Effect of Human Infant Gut Microbiota on Mouse Behavior, Dendritic Complexity, and Myelination

Dubey,

Roychoudhury,

Alex

et al. 2023

Preprint

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The mammalian gut microbiome influences numerous developmental processes. In human infants it has been linked with cognition, social skills, hormonal responses to stress, and brain connectivity. Yet, these associations are not necessarily causal. The present study tested whether two microbial stool communities, common in human infants, affected behavior, myelination, dendritic morphology, and spine density when used to colonize mouse models. Humanized animals were more like specific-pathogen free mice than germ-free mice for most phenotypes, although in males, both humanized groups were less social. Both humanized groups had thinner myelin sheaths in the hippocampus, than did germ-free animals. Humanized animals were similar to each other except for dendritic morphology and spine density where one group had greater dendritic length in the prefrontal cortex, greater dendritic volume in the nucleus accumbens, and greater spine density in both regions, compared to the other. Results add to a body of literature suggesting the gut microbiome impacts brain development.

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Section: Discussionmentioning

confidence: 99%

Effect of Human Infant Gut Microbiota on Mouse Behavior, Dendritic Complexity, and Myelination

Dubey,

Roychoudhury,

Alex

et al. 2023

Preprint

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“…Maladaptive neuroplastic changes in patients with MDD may be caused by chronic stress responses or other negative stimuli. A recent meta-analytic study exploring the structural and functional abnormalities in MDD demonstrated a large reduction in volume and loss of dendritic spines essential for neural connections in key brain regions, such as the prefrontal cortex (PFC), nucleus accumbens (NAc), and hippocampus (HIP), which may be due to the disruption of the brain’s pro-adaptation to stress through growth and reorganization in neural networks ( 14 , 15 ). Advances in neuroscience have provided further insights into the dysregulation of neurotrophic factors in the pathogenesis of MDD and anxiety.…”

Section: An Integrated Overview Of Depressive Disordermentioning

confidence: 99%

Exercise as an antidepressant: exploring its therapeutic potential

Hwang,

Koo,

Kim

et al. 2023

Front. Psychiatry

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The COVID-19 pandemic has increased the prevalence of depressive disorders worldwide, requiring alternative treatments beyond medication and psychotherapy. Exercise has positive effects on the brain; therefore, it has emerged as a promising therapeutic option for individuals with depression. Considerable research involving humans and animals offers compelling evidence to support the mental health benefits of physical activity or exercise mediated by the regulation of complex theoretical paradigms. However, challenges such as conducting long-term follow-up assessments and considering individual characteristics remain in human studies despite extensive efforts. While animal studies provide valuable insights into the potential benefits of exercise and its impact on outcomes related to depression and anxiety in rodents exposed to different stress paradigms, translating the findings to humans requires careful evaluation. More research is needed to establish precise exercise prescription guidelines and to better understand the complex relationship between exercise and depressive disorders. Therefore, this concise review explores the evidence supporting exercise intervention as an antidepressant treatment and its underlying mechanisms.

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“…Cortico-striatal structures are regulated by dopaminergic and serotonergic systems which affect impulsive choice ( 1 , 7 , 15 , 18 , 29 – 31 ). Mesolimbic dopamine, originating from the ventral tegmental area terminating in ventral striatum, regulates behavioral activation, motivation, and reinforcing properties ( 12 , 32 , 33 ).…”

Section: Introductionmentioning

confidence: 99%

Methylphenidate, but not citalopram, decreases impulsive choice in rats performing a temporal discounting task

Koloski,

Terry,

Lee

et al. 2024

Front. Psychiatry

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IntroductionDrugs targeting monoamine systems remain the most common treatment for disorders with impulse control impairments. There is a body of literature suggesting that drugs affecting serotonin reuptake and dopamine reuptake can modulate distinct aspects of impulsivity – though such tests are often performed using distinct behavioral tasks prohibiting easy comparisons.MethodsHere, we directly compare pharmacologic agents that affect dopamine (methylphenidate) vs serotonin (citalopram) manipulations on choice impulsivity in a temporal discounting task where rats could choose between a small, immediate reward or a large reward delayed at either 2 or 10s. In control conditions, rats preferred the large reward at a small (2s) delay and discounted the large reward at a long (10s) delay.ResultsMethylphenidate, a dopamine transport inhibitor that blocks reuptake of dopamine, dose-dependently increased large reward preference in the long delay (10s) block. Citalopram, a selective serotonin reuptake inhibitor, had no effect on temporal discounting behavior. Impulsive behavior on the temporal discounting task was at least partially mediated by the nucleus accumbens shell. Bilateral lesions to the nucleus accumbens shell reduced choice impulsivity during the long delay (10s) block. Following lesions, methylphenidate did not impact impulsivity.DiscussionOur results suggest that striatal dopaminergic systems modulate choice impulsivity via actions within the nucleus accumbens shell, whereas serotonin systems may regulate different aspects of behavioral inhibition/impulsivity.

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Nucleus accumbens in the pathogenesis of major depressive disorder: A brief review

Cited by 11 publications

References 140 publications

Effect of Human Infant Gut Microbiota on Mouse Behavior, Dendritic Complexity, and Myelination

Effect of Human Infant Gut Microbiota on Mouse Behavior, Dendritic Complexity, and Myelination

Exercise as an antidepressant: exploring its therapeutic potential

Methylphenidate, but not citalopram, decreases impulsive choice in rats performing a temporal discounting task

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