Nucleus Replacement With the DASCOR Disc Arthroplasty Device

Ahrens, Michael J.; Tsantrizos, Anthony; Donkersloot, Peter; Martens, Frederic; Lauweryns, Philippe; Huec, Jean Charles Le; Moszko, Slawomir; Fekete, Zsolt; Sherman, John E.; Yuan, Hansen A.; Halm, H.

doi:10.1097/brs.0b013e3181a3967f

Cited by 46 publications

(22 citation statements)

References 8 publications

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“…In the case of the DASCOR device no peer-reviewed data appears to be readily available in terms of cell response, although early clinical results for the DASCOR device suggest it is biologically safe [44], Sterilization of the initial components has also been an issue for both acrylic and ceramic cements, where different types of sterilization procedures (e.g. EtO gas or γ-irradiation) may have detrimental effects on the material properties [45,46].…”

Section: Biocompatibilitymentioning

confidence: 99%

“…There are ceramic particles in the degradable material cited previously, which may infer a certain amount of radiopacity, but this was not evaluated [37]. For the polyurethane product, there is no mention of a radiopacifier within the final material, although a balloon is injected with a radiopaque material before its extraction and insertion of a second balloon, which is then filled with polyurethane [44].…”

Section: Radiopacitymentioning

confidence: 99%

“…In a worst-case scenario, the implant can protrude into the spinal canal, possibly giving rise to neurological problems. A balloon containing the actual material, as in the case of the DASCOR device [44,38], is therefore an attractive solution. However, although the natural endplates are concave and may thus be able to contain a material to a certain extent, they may look very different in patients with degenerative disc disease.…”

Section: Containmentmentioning

confidence: 99%

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Strategies towards injectable, load-bearing materials for the intervertebral disc: a review and outlook

Persson

Berg²

2012

J Mater Sci: Mater Med

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Currently available treatments for the degenerated intervertebral disc present disadvantages, such as surgical invasiveness and inadequate load distribution results. Load-bearing, injectable materials may be interesting for future therapies, but have not been studied in depth.In this study, the existing literature was screened for studies on injectable materials for the intervertebral disc and a rationale for load-bearing, injectable materials was formulated.Requirements for such a material were discussed, partly based on the experience of materials used for similar applications. Important properties were discussed and found to include biocompatibility, bioactivity, porosity, handling, injectability, working time, setting time, radiopacity, containment and mechanical properties, where several of these properties are linked to one another.Load--bearing injectables for the disc 2In conclusion, there is a need for consensus on the properties of new materials developed for use in minimally invasive procedures in the spine. A substantial amount of attention may need to be given to non-toxic setting reactions.

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Section: Biocompatibilitymentioning

confidence: 99%

Section: Radiopacitymentioning

confidence: 99%

Section: Containmentmentioning

confidence: 99%

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Strategies towards injectable, load-bearing materials for the intervertebral disc: a review and outlook

Persson

Berg²

2012

J Mater Sci: Mater Med

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“…Mean preoperative visual analog scale pain scores of 7.6 and Oswestry Disability Index (ODI) scores of 57.5% improved significantly after 6 months (decreased to 3.4 and 24.5%, respectively) and were maintained throughout the 2 years (3.3 and 23.2%, respectively). 1 However, forty patients (47.1%) were reported to have experienced adverse events, with 14 patients (16.4%) having serious adverse events, including 7 who had to have the device explanted. Analgesic use following the surgery decreased 84.6% and was almost nonexistent at the 2-year follow-up, and radiographic results demonstrated maintenance of disc height, with no device subsidence or expulsion.…”

mentioning

confidence: 99%

“…The role of these postoperative interventions warrants further research. report, Ahrens et al 1 presented interim 2-year clinical results of the device from patients enrolled in a prospective, nonrandomized, multicenter study. A total of 85 patients (45 male, 40 female; mean  SD age, 38.8  8.6 years; age range, 22.2-59.6 years) were followed before and after nucleoplasty at 6 weeks and at 3, 6, 12, and 24 months.…”

mentioning

confidence: 99%

Rehabilitation Following Lumbosacral Percutaneous Nucleoplasty: A Case Report

Puentedura¹,

Brooksby²,

Wallmann³

et al. 2010

J Orthop Sports Phys Ther

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Development and initial characterization of a chemically stabilized elastin-glycosaminoglycan-collagen composite shape-memory hydrogel for nucleus pulposus regeneration

Mercuri

Addington

Pascal

et al. 2014

J. Biomed. Mater. Res.

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Nucleus pulposus (NP) is a resilient and hydrophilic tissue which plays a significant role in the biomechanical function of the intervertebral disc (IVD). Destruction of the NP extracellular matrix (ECM) is observed during the early stages of IVD degeneration. Herein, we describe the development and initial characterization of a novel biomaterial which attempts to recreate the resilient and hydrophilic nature of the NP via the construction of a chemically stabilized elastin-glycosaminoglycan-collagen (EGC) composite hydrogel. Results demonstrated that a resilient, hydrophilic hydrogel which displays a unique "shape-memory" sponge characteristic could be formed from a blend of soluble elastin aggregates, chondroitin-6-sulfate, hyaluronic acid and collagen following freeze-drying, stabilization with a carbodiimide and penta-galloyl glucose-based fixative, and subsequent partial degradation with glycosaminoglycan degrading enzymes. The resultant material exhibited the ability to restore its original dimensions and water content following multi-cycle mechanical compression and illustrated resistance to accelerated enzymatic degradation. Preliminary in vitro studies utilizing human adipose derived stem cells (hADSCs) demonstrated that the material was cytocompatible and supported differentiation towards an NP cell-like phenotype. In vivo biocompatibility studies illustrated host cell infiltration and evidence of active remodeling following 4 weeks of implantation. Feasibility studies demonstrated that the EGC hydrogel could be delivered via minimally invasive methods.

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Nucleus Replacement With the DASCOR Disc Arthroplasty Device

Abstract: The interim outcomes showed significant improvements in mean ODI and VAS scores. The results of these European studies suggest that the DASCOR Device may be a safe and effective less-invasive surgical option for patients with DDD.

Cited by 46 publications

References 8 publications

Strategies towards injectable, load-bearing materials for the intervertebral disc: a review and outlook

Strategies towards injectable, load-bearing materials for the intervertebral disc: a review and outlook

Rehabilitation Following Lumbosacral Percutaneous Nucleoplasty: A Case Report

Development and initial characterization of a chemically stabilized elastin-glycosaminoglycan-collagen composite shape-memory hydrogel for nucleus pulposus regeneration

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