Numerical dosimetric calculations for in vitro field expositions in the THz frequency range

Jastrow, C.; Kleine‐Ostmann, Thomas; Schräder, Thorsten

doi:10.5194/ars-8-1-2010

Cited by 9 publications

(4 citation statements)

References 12 publications

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“…This analysis was performed according to the “ISO/IEC Guide 98-3:2008: Uncertainty of measurement – Part 3: Guide to the expression of uncertainty in measurement (GUM)”. Using the finite integration method, it has been determined numerically that empty field power densities of 2 mW/cm 2 result in maximum specific absorption rates of 13.34 W/kg [28] .…”

Section: Methodsmentioning

confidence: 99%

Terahertz Electromagnetic Fields (0.106 THz) Do Not Induce Manifest Genomic Damage In Vitro

et al. 2012

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Terahertz electromagnetic fields are non-ionizing electromagnetic fields in the frequency range from 0.1 to 10 THz. Potential applications of these electromagnetic fields include the whole body scanners, which currently apply millimeter waves just below the terahertz range, but future scanners will use higher frequencies in the terahertz range. These and other applications will bring along human exposure to these fields. Up to now, only a limited number of investigations on biological effects of terahertz electromagnetic fields have been performed. Therefore, research is strongly needed to enable reliable risk assessment.Cells were exposed for 2 h, 8 h, and 24 h with different power intensities ranging from 0.04 mW/cm2 to 2 mW/cm2, representing levels below, at, and above current safety limits. Genomic damage on the chromosomal level was measured as micronucleus formation. DNA strand breaks and alkali-labile sites were quantified with the comet assay. No DNA strand breaks or alkali-labile sites were observed as a consequence of exposure to terahertz electromagnetic fields in the comet assay. The fields did not cause chromosomal damage in the form of micronucleus induction.

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Section: Methodsmentioning

confidence: 99%

Terahertz Electromagnetic Fields (0.106 THz) Do Not Induce Manifest Genomic Damage In Vitro

et al. 2012

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“…In addition, we analyzed the project summaries for the "THz-BRIDGE" project-the first international THz biological research project [149]. We also examined more recent work initiated by the German Federal Office for Radiation Protection (Bundesamt für Strahlenschutz -BfS) [150] and the THz-BEAM projects. We also searched for relevant publications in the journal entitled "Bulletin of Experimental Biology and Medicine."…”

Section: Challenges and Considerations For Conducting Terahertz Biolomentioning

confidence: 99%

Invited Review Article: Current State of Research on Biological Effects of Terahertz Radiation

Wilmink

Grundt

2011

J Infrared Milli Terahz Waves

277

186

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In recent years, terahertz radiation sources are increasingly being exploited in military and civil applications. However, only a few studies have so far been conducted to examine the biological effects associated with terahertz radiation. In this study, we evaluated the cellular response of mesenchymal mouse stem cells exposed to THz radiation. We apply low-power radiation from both a pulsed broad-band (centered at 10 THz) source and from a CW laser (2.52 THz) source. Modeling, empirical characterization, and monitoring techniques were applied to minimize the impact of radiation-induced increases in temperature. qRT-PCR was used to evaluate changes in the transcriptional activity of selected hyperthermic genes. We found that temperature increases were minimal, and that the differential expression of the investigated heat shock proteins (HSP105, HSP90, and CPR) was unaffected, while the expression of certain other genes (Adiponectin, GLUT4, and PPARG) showed clear effects of the THz irradiation after prolonged, broad-band exposure.

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“…A detailed model of the sample container with DMEM has been set up with εr=5.98 and tanδ=1.83 measured for DMEM by using THz time-domain spectroscopy and values for the container material taken from product data sheets (dish: εr=2.28 and tanδ=0.0001, foil: εr =2.34 and tan δ=0.005, lid: εr=3 and tanδ=0.01) [3]. No distinction has been made between the dielectric properties of DMEM and the cells contained in there.…”

Section: Dosimetric Calculationsmentioning

confidence: 99%

“…In order to verify the results and further clarify the effect, a field exposition setup for frequencies between 100 GHz and 2.52 THz was designed. In order to produce reliable results, the field strength can be set to a value determined traceable to the SI units, the environmental and exposition parameters are monitored during exposition and, at 106 GHz, dosimetrical calculations have been performed to determine the SAR values at the location of the cells [3]. Using the setup, an extensive exposition campaign on human skin cells (HaCaT keratinocyte cell line and primary dermal fibroblasts), has been performed.…”

Section: Introductionmentioning

confidence: 99%

Field exposition and dosimetry with (sub)mm waves

Kleine‐Ostmann

Jastrow

Schräder

2012

2012 Conference on Precision Electromagnetic Measurements

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In vitro field exposition experiments with biological samples performed to explore possible detrimental effects of non-ionizing radiation on biological systems require appropriate experimental setups, careful control and monitoring of environmental and exposition conditions and a reliable dosimetry to quantify the amount of stress imposed upon the sample. In the Terahertz frequency range, the experimental conditions are difficult to control and exact dosimetry is hindered by the fact that numerical field calculations are restricted due to computational complexity. Here we present a field exposition setup that has been used for in vitro studies in the THz frequency range. At 106 GHz, the empty-field power density at the location of the sample containers was set traceable to the SI units and dosimetric calculations yielding the specific absorption rate and heat distribution in the sample container were performed.Index Terms -In vitro field exposition experiments, biological effects of sub-mm and Terahertz radiation, dosimetry of nonionizing radiation.

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Numerical dosimetric calculations for in vitro field expositions in the THz frequency range

Cited by 9 publications

References 12 publications

Terahertz Electromagnetic Fields (0.106 THz) Do Not Induce Manifest Genomic Damage In Vitro

Terahertz Electromagnetic Fields (0.106 THz) Do Not Induce Manifest Genomic Damage In Vitro

Invited Review Article: Current State of Research on Biological Effects of Terahertz Radiation

Field exposition and dosimetry with (sub)mm waves

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