As a new cooling medium, Helium/ Supercritical Carbon Dioxide (He / S-CO2) binary mixture gas can effectively improve the heat transfer capability. In this paper, the heat transfers synergistic performance of He / S-CO2 with fins structure were numerically simulated by ANSYS / CFD method. The results show that the pressure drop in the channel decreases gradually with the increase of volume fraction of S-CO2. Comparing with smooth channel, fin structure can significantly improve the intensity of convective heat transfer intensity, the average Nusselt number of flow channel with finger fins are increased by 80%. The heat transfer efficiency of He/S-CO2 binary mixture gas coupled with heat transfer enhancement structure (triangular fins) is increased by 310% at the condition of volume ratio of S-CO2 to He with 2:1. Further study on the optimized scheme of first wall (FW) of International Thermonuclear Experimental Reactor (ITER) China Helium-Cooled Ceramic Breeder-Test Blanket Module (HCCB-TBM) show that triangular fins are placed on the inner surface of FW faced deuterium-tritium plasma, and the optimized distance between fin pitches is 7 ~ 10mm. The results can provide meaningful references for the cooling scheme design of the FW in ITER.