Numerical Modelling of Transdermal Delivery from Matrix Systems: Parametric Study and Experimental Validation with Silicone Matrices

Snorradóttir, Bergthóra S.; Jónsdóttir, Fjóla; Sigurðsson, Sven; Másson, Már

doi:10.1002/jps.24052

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…The diffusion coefficient value of the reservoir system would depend on the reservoir for TDD of IBU and Diclofenac (MW: 296.15 g mol -1 ) from a silicon matrix. The diffusion coefficient value of IBU in skin and reservoir are taken as 3.6×10 -11 m 2 s -1 and 1×10 -11 m 2 s -1 , as estimated from the experiments performed by Snorradóttir et al (2014).…”

Section: Diffusion Coefficient In Reservoir and Skinmentioning

confidence: 99%

“…properties Snorradóttir et al (2014). developed a model for the TDD of ibuprofen from silicon matrix systems.…”

mentioning

confidence: 99%

“…The model was validated with the in vitro experiments performed using excised dorsal skin of a mouse mounted on a Franz diffusion cell. The modelling study was used to estimate the diffusion coefficient and dissolution rate constant for the matrix system and skin based on the release profile Snorradóttir et al (2014). performed a parametric study…”

mentioning

confidence: 99%

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Super-swelling hydrogel-forming microneedle based transdermal drug delivery: Mathematical modelling, simulation and experimental validation

Yadav

Nasiri

Vora

et al. 2022

International Journal of Pharmaceutics

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Section: Diffusion Coefficient In Reservoir and Skinmentioning

confidence: 99%

“…properties Snorradóttir et al (2014). developed a model for the TDD of ibuprofen from silicon matrix systems.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Super-swelling hydrogel-forming microneedle based transdermal drug delivery: Mathematical modelling, simulation and experimental validation

Yadav

Nasiri

Vora

et al. 2022

International Journal of Pharmaceutics

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“…Scientific community while studying and modelling the medication transfer process throughout the delivery devices and the consequent release to the neighboring environment drove the technological improvement in drug delivery vehicles. Several studies have been publishing, proposing new and more accurate models describing transdermal drug release and the skin barrier (Anissimov et al (2013), Frasch and Barbero (2013), Jepps et al (2013), Kalia and Guy (2001), Khanday and Rafiq (2015), Snorradõttir et al (2014)).…”

Section: Introductionmentioning

confidence: 99%

Drug Release in Transdermal Devices: A Brief Parametric Study

Pinheiro¹,

Almeida²,

Silva³

2019

Frontiers in Heat and Mass Transfer

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In the last decades, polymeric systems were essayed and applied successfully as vehicles for transdermal delivery devices of active principles. Applications in contraception, pain control, and smoking cessation are already frequent. A crucial aspect in the development of new formulations is the maintenance of the therapeutic drug concentration range for long periods. Recognizing this topic as interesting and challenging, simple models to describe drug release from a transdermal device were developed with the purpose to perform a parametric sensitivity analysis. Assuming drug diffusion within the polymeric delivery system as the dominant mechanism the models were developed and implemented. Transdermal patches made of the single adhesive material layer (the drug reservoir) and made of two layers were considered during drug release modeling to the skin. The sensitivity analysis of parameters such as drug diffusion coefficient and initial drug concentration brought insight into drug transfer process inside the patches, revealing itself as a useful tool in the optimization of drug delivery devices.

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A Theoretical Study on Inhibition of Melanoma with Controlled and Targeted Delivery of siRNA via Skin Using SPACE-EGF

et al. 2017

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Melanoma is a potentially lethal skin cancer with high mortality rate. Recently, the peptide-mediated transdermal delivery of small interference RNA (siRNA) emerges as a promising strategy to treat melanoma by inducing the apoptosis of tumor cells, but the related theoretical model describing the delivery of siRNA under the effect of SPACE-EGF, the growth inhibition of melanoma and the dynamic expanding of the bump on the skin due to the growth of melanoma has not been reported yet. In this article, a theoretical model is developed to describe the percutaneous siRNA delivery mediated by SPACE-EGF to melanoma and the growth inhibition of melanoma. The results present the spatial-temporal distribution of siRNA and the growth of melanoma under the inhibition of siRNA, which shows a good consistency with the experimental results. In addition, this model represents the uplift process of tumors on the skin surface. The model presented here is a useful tool to understand the whole process of the SPACE-EGF-mediated delivery of the siRNA to melanoma through skin, to predict the therapeutic effect, and to optimize the therapeutic strategy, providing valuable references for the treatment of melanoma.

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Numerical Modelling of Transdermal Delivery from Matrix Systems: Parametric Study and Experimental Validation with Silicone Matrices

Cited by 6 publications

References 27 publications

Super-swelling hydrogel-forming microneedle based transdermal drug delivery: Mathematical modelling, simulation and experimental validation

Super-swelling hydrogel-forming microneedle based transdermal drug delivery: Mathematical modelling, simulation and experimental validation

Drug Release in Transdermal Devices: A Brief Parametric Study

A Theoretical Study on Inhibition of Melanoma with Controlled and Targeted Delivery of siRNA via Skin Using SPACE-EGF

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