Developing ways to increase centrifugal pumps’ pressure and power characteristics is a critical problem in up-to-date engineering. There are many ways to resolve it, but each has advantages and flaws. The presented article aimed to ensure higher energy efficiency indicators by using a counter-rotating pumping stage with trimming. During the research, the comprehensive approach was based on CFD modeling and the Moore–Penrose pseudoinverse approach for overestimated systems. According to the obtained data, pumps with a counter-rotating stage allowed the pressure head to be significantly increased compared with the standard design of the flow part. Notably, for pumping units CPS 180/1900 with a basic stage, the pressure head of 127 m was reached. However, when using a counter-rotating stage, the pressure head could be increased up to 270 m, which was 2.1 times higher. Therefore, to ensure unchanged characteristics when using centrifugal pumps with the counter-rotating stage, the weight and size indicators can be significantly reduced compared to the traditional design scheme. The proposed numerical and analytical approaches allow estimating the highest pressure and energy characteristics values.