Numerical simulation of the effect of necrosis area in systemic delivery of magnetic nanoparticles in hyperthermia cancer treatment

Sefidgar, Mostafa; Bashooki, Ehsan; Shojaee, Pejman

doi:10.1016/j.jtherbio.2020.102742

Cited by 21 publications

(7 citation statements)

References 48 publications

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“…Moreover, the heating efficiency of MNPs exposed to AMF at targeted cells can also be limited due to tumor properties. The diverse tumor properties such as its heterogeneity and diameter can significantly affect the MNPs concentration, their heating efficiency, and the temperature distribution [41][42][43]. In addition, design and construction of devices that are capable of generating pulsed power with short cycles such as 10 s and duty of 0.9 is a challenging task.…”

Section: Discussionmentioning

confidence: 99%

Theoretical Analysis for Using Pulsed Heating Power in Magnetic Hyperthermia Therapy of Breast Cancer

Cao

Hadadian

et al. 2021

IJMS

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In magnetic hyperthermia, magnetic nanoparticles (MNPs) are used to generate heat in an alternating magnetic field to destroy cancerous cells. This field can be continuous or pulsed. Although a large amount of research has been devoted to studying the efficiency and side effects of continuous fields, little attention has been paid to the use of pulsed fields. In this simulation study, Fourier’s law and COMSOL software have been utilized to identify the heating power necessary for treating breast cancer under blood flow and metabolism to obtain the optimized condition among the pulsed powers for thermal ablation. The results showed that for small source diameters (not larger than 4 mm), pulsed powers with high duties were more effective than continuous power. Although by increasing the source domain the fraction of damage caused by continuous power reached the damage caused by the pulsed powers, it affected the healthy tissues more (at least two times greater) than the pulsed powers. Pulsed powers with high duty (0.8 and 0.9) showed the optimized condition and the results have been explained based on the Arrhenius equation. Utilizing the pulsed powers for breast cancer treatment can potentially be an efficient approach for treating breast tumors due to requiring lower heating power and minimizing side effects to the healthy tissues.

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Section: Discussionmentioning

confidence: 99%

Theoretical Analysis for Using Pulsed Heating Power in Magnetic Hyperthermia Therapy of Breast Cancer

Cao

Hadadian

et al. 2021

IJMS

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“…With regards to the question of which is the best cell death pathway in MH applications, there exists a conflict between two postures: some authors claim that only necrosis, associated with ablation, can exterminate cancer cells [158], while others highlight that extensive necrosis can be dangerous for healthy tissues and reduce tissue permeability to drugs and thus apoptosis must be the sought for alternative [159]. On the other hand, unbalanced apoptosis plays a crucial role in many diseases, including degenerative disorders and many cancer types.…”

Section: Magnetic Hyperthermia and The Heat Shock Responsementioning

confidence: 99%

Physical and Cellular Basis of Oncologic Magnetic Thermotherapy

Ghilini¹

2023

Magnetic Nanoparticles for Biomedical Applications

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Magnetic thermotherapy (MT) for treating solid tumors employs magnetic hyperthermia (MH) protocols. Superparamagnetic iron oxide nanoparticles -nowadays considered nanomedicines- are delivered to the tumor to induce temperature elevations upon the application of an external alternating magnetic field in the radiofrequency range. This treatment activates cell death pathways and sensitizes cells to other cancer therapies. Much information is available on magnetic materials preparation and functionalization, physical relaxation mechanisms behind magnetic heating, and designed devices for field generation and magnetic material tracking, but further insight is still needed about the nature and characteristics of the cellular response to MH. In this chapter, the physical foundations of MT are thoroughly discussed and complemented by a general overview of the cellular responses induced to counteract the various sources of stress associated with this technology.

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“… 96 Traditionally, necrosis is regarded as an accidental and genetically unprogrammed form of cell death (programmed necrosis is known as “necroptosis”). 97 Necrosis is regarded as “repair cell death” in tumor progression and aggressiveness. 98 During necrosis, the cell swells, the cell membrane is ruptured, and the cytoplasmic content is released into the extracellular space.…”

Section: The Role Of Lncrnas In Necrosismentioning

confidence: 99%

The Crosstalk Between Long Non-Coding RNAs and Various Types of Death in Cancer Cells

Tang

Zhu

Liang

et al. 2021

Technol Cancer Res Treat

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With the increasing aging population, cancer has become one of the leading causes of death worldwide, and the number of cancer cases and deaths is only anticipated to grow further. Long non-coding RNAs (lncRNAs), which are closely associated with the expression level of downstream genes and various types of bioactivity, are regarded as one of the key regulators of cancer cell proliferation and death. Cell death, including apoptosis, necrosis, autophagy, pyroptosis, and ferroptosis, plays a vital role in the progression of cancer. A better understanding of the regulatory relationships between lncRNAs and these various types of cancer cell death is therefore urgently required. The occurrence and development of tumors can be controlled by increasing or decreasing the expression of lncRNAs, a method which confers broad prospects for cancer treatment. Therefore, it is urgent for us to understand the influence of lncRNAs on the development of different modes of tumor death, and to evaluate whether lncRNAs have the potential to be used as biological targets for inducing cell death and predicting prognosis and recurrence of chemotherapy. The purpose of this review is to provide an overview of the various forms of cancer cell death, including apoptosis, necrosis, autophagy, pyroptosis, and ferroptosis, and to describe the mechanisms of different types of cancer cell death that are regulated by lncRNAs in order to explore potential targets for cancer therapy.

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Numerical simulation of the effect of necrosis area in systemic delivery of magnetic nanoparticles in hyperthermia cancer treatment

Cited by 21 publications

References 48 publications

Theoretical Analysis for Using Pulsed Heating Power in Magnetic Hyperthermia Therapy of Breast Cancer

Theoretical Analysis for Using Pulsed Heating Power in Magnetic Hyperthermia Therapy of Breast Cancer

Physical and Cellular Basis of Oncologic Magnetic Thermotherapy

The Crosstalk Between Long Non-Coding RNAs and Various Types of Death in Cancer Cells

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