Numerical Simulation on Thermal Response of Laser-Irradiated Biological Tissues Embedded with Liquid Metal Nanoparticles

Wang, Dawei; Rao, Wei

doi:10.1007/s11630-022-1623-8

Cited by 8 publications

(3 citation statements)

References 48 publications

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“…5,[18][19][20][21] In particular, sonication techniques, using a common bath sonication or sonication horn, have been reported for the controlled synthesis of micron-sized and nano-sized Ga particles, respectively. 20,[22][23][24] Many parameters, such as sonication time and power, temperature, solution and additives, were investigated and reported to influence the size distribution, oxide content and crystallinity, surface oxide composition and functionalisation, and phase separation. 5,25 The as-formed Ga particles can retain fluidity while exhibiting metallic-like properties such as thermal conductivity and can be utilised to form electrically conductive pathways.…”

Section: Introductionmentioning

confidence: 99%

Formation of inorganic liquid gallium particle–manganese oxide composites

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Formation of inorganic liquid gallium particle–manganese oxide composites

et al. 2023

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“…However, phototherapy faces the limitations of low tissue penetration for treating deep-seated tumors, which brings difficulties in effectively destroying deep-seated tumors for the release of tumor antigens and the activation of ISCVs. Therefore, intermittent heating technique or interventional methods , are still needed. (3) The current investigations have not yet delved into the pervasive mechanisms underlying the antigen adsorbability and delivery routes, particularly regarding the fundamentally different fluidity, deformability and metallicity in comparison with other rigid inorganic or soft organic nanomaterials.…”

Section: Discussionmentioning

confidence: 99%

Liquid Metal Nanoplatform Based Autologous Cancer Vaccines

Wang

et al. 2023

ACS Nano

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Therapeutic cancer vaccines have been vigorously sought to bolster host adaptive immunity against metastatic cancers, but tumor heterogeneity, ineffective antigen utilization, and immunosuppressive tumor microenvironment hinder their clinical applications. Autologous antigen adsorbability and stimulus-release carrier coupling with immunoadjuvant capacity are urgent for personalized cancer vaccines. Here, we propose a perspective strategy of using a multipotent gallium-based liquid metal (LM) nanoplatform for personalized in situ cancer vaccines (ISCVs). The antigen-capturing and immunostimulatory LM nanoplatform can not only effectively destroy orthotopic tumors to generate multifarious autologous antigens upon external energy stimulation (photothermal/photodynamic effect) but also capture and transport antigens into dendritic cells (DCs) to enhance antigen utilization (adequate DCs uptake, antigen-endo/lysosomal escape) and facilitate DCs activation (mimic alum immunoadjuvant capacity), which ultimately awaken systemic antitumor immunity (expand cytotoxic T lymphocytes and modulate tumor microenvironment). With immune checkpoint blockade (anti-PD-L1) to further relieve the immunosuppressive tumor microenvironment, the positive tumoricidal immunity feedback loop was established to effectively eliminate orthotopic tumors, inhibit abscopal tumor growth, relapse, and metastasis as well as tumor-specific prevention. Collectively, this study demonstrates the potential of a multipotent LM nanoplatform for personalized ISCVs, which will open frontier exploration of LM-based immunostimulatory biomaterials and may encourage further investigation of precise individualized immunotherapy.

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“…A mathematical framework coupling a Monte-Carlo photo-transport model with Penne’s bioheat transfer model was used by Wang et al . for calculating the temperature increases of liquid metal NPs [ 155 ]. The heat generation of metallic NPs has been estimated by Beik et al ., who developed computational models to describe the plasmonic excitation of single AuNP and heat generation after laser illumination in a finite-element modelling framework, such as in COMSOL Multiphysics.…”

Section: Atomistic Simulations Of Ptt and Pdt Nanomaterialsmentioning

confidence: 99%

Biomolecule-mimetic nanomaterials for photothermal and photodynamic therapy of cancers: Bridging nanobiotechnology and biomedicine

Yang

Zhu

et al. 2022

J Nanobiotechnol

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Nanomaterial-based phototherapy has become an important research direction for cancer therapy, but it still to face some obstacles, such as the toxic side effects and low target specificity. The biomimetic synthesis of nanomaterials using biomolecules is a potential strategy to improve photothermal therapy (PTT) and photodynamic therapy (PDT) techniques due to their endowed biocompatibility, degradability, low toxicity, and specific targeting. This review presents recent advances in the biomolecule-mimetic synthesis of functional nanomaterials for PTT and PDT of cancers. First, we introduce four biomimetic synthesis methods via some case studies and discuss the advantages of each method. Then, we introduce the synthesis of nanomaterials using some biomolecules such as DNA, RNA, protein, peptide, polydopamine, and others, and discuss in detail how to regulate the structure and functions of the obtained biomimetic nanomaterials. Finally, potential applications of biomimetic nanomaterials for both PTT and PDT of cancers are demonstrated and discussed. We believe that this work is valuable for readers to understand the mechanisms of biomimetic synthesis and nanomaterial-based phototherapy techniques, and will contribute to bridging nanotechnology and biomedicine to realize novel highly effective cancer therapies.

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Numerical Simulation on Thermal Response of Laser-Irradiated Biological Tissues Embedded with Liquid Metal Nanoparticles

Cited by 8 publications

References 48 publications

Formation of inorganic liquid gallium particle–manganese oxide composites

Formation of inorganic liquid gallium particle–manganese oxide composites

Liquid Metal Nanoplatform Based Autologous Cancer Vaccines

Biomolecule-mimetic nanomaterials for photothermal and photodynamic therapy of cancers: Bridging nanobiotechnology and biomedicine

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