Numerical study of the effect of nasopharynx airway obstruction on the transport and deposition of nanoparticles in nasal airways

Sun, Qinyuan; Dong, Jingliang; Zhang, Ya; Tian, Lin; Tu, Jiyuan

doi:10.1007/s42757-022-0143-9

Cited by 14 publications

(5 citation statements)

References 36 publications

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“…In this study, we explored the adjoint-CFD approach in studying the effects of mouth-tongue shape on the dosimetry of orally inhaled vapors. A practical method to study the influences of morphological variations on aerosol transport and deposition can open a new door to understanding drug bioavailability and bioequivalence among different subjects and between health and disease [58][59][60][61]. Despite large intersubject and intrasubject variability in respiratory anatomy, their effects on inhalation dosimetry have been historically less studied than other parameters, such as the flow rate and particle size.…”

Section: Discussionmentioning

confidence: 99%

Adjoint Solver-Based Analysis of Mouth-Tongue Morphologies on Vapor Deposition in the Upper Airway

Talaat,

Si,

2024

Preprint

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Even though inhalation dosimetry is determined by three factors (i.e., breathing, aerosols, and the respiratory tract), the first two categories have been more widely studied than the last. Both breathing and aerosols are quantitative variables that can be easily changed, while respiratory airway morphologies are difficult to reconstruct, modify, and quantify. Despite several methods are available for model reconstruction and modification, developing an anatomically accurate airway model and morphing it to various physiological conditions remains labor-intensive and technically challenging. The objective of this study is to explore the feasibility of using an adjoint-CFD model to understand airway shape effects on vapor deposition and control vapor flux into the lung. A mouth-throat model was used, with the shape of the mouth and tongue being automatically varied via adjoint morphing, and the vapor transport being simulated using ANSYS Fluent coupled with a wall absorption model. Two chemicals with varying adsorption rates, Acetaldehyde and Benzene, were considered, which exhibited large differences in dosimetry sensitivity to airway shapes. For both chemicals, large shape deformations were explored to find the maximal possible morphing; both the maximal and intermediate deformations were simulated for morphology parametric studies. Results show that changing the mouth-tongue shape can alter the oral filtration by 3.2% for Acetaldehyde and 0.27% for Benzene under a given inhalation condition. This study demonstrates that the hybrid adjoint-CFD approach can be a practical and efficient method to investigate morphology-associated variability in inhalation dosimetry of vapors and nanomedicines.

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Section: Discussionmentioning

confidence: 99%

Adjoint Solver-Based Analysis of Mouth-Tongue Morphologies on Vapor Deposition in the Upper Airway

Talaat,

Si,

2024

Preprint

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“…The mechanisms of droplet capturing particles mainly involve impaction, interception, and diffusion. − The capturing efficiency of a single droplet due to impaction can be calculated by the following equation: E normalI = true( S t k normald S t k normald + 1.0 true) l S t k normald = v rel d normalp 2 ρ normalp 18 μ normalg d normald l = 0.759 S t k normald − 0.245 …”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Pilot-Scale Investigation on a Spraying Pretreatment Process Integrated with an Axial Flow Cyclone to Separate Fine Particles with Low Energy Consumption

Wang,

Song,

Liu

et al. 2023

Ind. Eng. Chem. Res.

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This study was designed to explore the synergistic enhancement of the spraying pretreatment section and axial flow cyclone on the separation of particles from gases. First, in the spraying pretreatment section, the effects of the gas flow rate, droplet flow rate, droplet diameter, and gas or droplet temperature on the collection efficiency of the particles and the supersaturation degree were analyzed. Then, the nucleation and growth process of fine insoluble particles were discussed. At last, combined with an axial flow cyclone, the influences of operating parameters on the separation efficiency and energy consumption were presented. Our results show that the spraying pretreatment can capture 80% of particles larger than 5 μm and can maintain a supersaturated environment. Fine particles (PM1.0) will be aggregated to above 6 μm quickly and removed in the axial flow cyclone with a separation efficiency of above 98%. In addition, the energy consumption of the integrated purification process in this study is reduced by 20.65%, on average, compared to that of an electrostatic precipitator. These findings provide new insights into the separation of fine particles in industrial applications.

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“…Sun et al [89] compared pre-and post-operative nasal airway models based on a 3-year-old nasal cavity model with apparent adenoid hypertrophy. The results showed that nasopharynx obstruction can induce significantly biased flow distribution in the central nasal passage even if the obstruction site is downstream of the nasal airway.…”

Section: Software For Selecting Desiccant Wheelsmentioning

confidence: 99%

Desiccant Technologies for Improving Air Quality: An Overview of the Brazilian Scenario and Comparison of Available Design Software for Manufactured Desiccant Wheels

Santiago

Nunes²,

Fontana³

et al. 2023

Processes

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A review of desiccant dehumidification technologies for improving air quality is presented, mainly focusing on alternatives for air conditioning systems for minimizing Sick Building Syndrome. The principles and types of desiccant wheels, as well as the existing selection software for these types of equipment, were reviewed and comparatively evaluated. The study focused on the Brazilian context; thus, information about this country’s air conditioning systems and laws were evaluated. Possible applications of desiccant wheels, such as their integration into cooling cycles and the sensible heat wheel, were also analyzed. Finally, several examples of commercial desiccant wheel selection software that are useful in many situations were evaluated. Nevertheless, it was evidenced that the available software could not perform an operation analysis for only a specific period. Therefore, creating computational tools to select desiccant wheels is essential when considering the data from the different Brazilian regions for a year.

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Numerical study of the effect of nasopharynx airway obstruction on the transport and deposition of nanoparticles in nasal airways

Cited by 14 publications

References 36 publications

Adjoint Solver-Based Analysis of Mouth-Tongue Morphologies on Vapor Deposition in the Upper Airway

Adjoint Solver-Based Analysis of Mouth-Tongue Morphologies on Vapor Deposition in the Upper Airway

Pilot-Scale Investigation on a Spraying Pretreatment Process Integrated with an Axial Flow Cyclone to Separate Fine Particles with Low Energy Consumption

Desiccant Technologies for Improving Air Quality: An Overview of the Brazilian Scenario and Comparison of Available Design Software for Manufactured Desiccant Wheels

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