This study provides insights into large fires in the Pantanal by analyzing the atmospheric conditions that influenced the rapid fire evolution between 13 and 14 November 2023, when fire fronts spread rapidly, leading to critical situations for firefighters. The observation-based analysis helped us to identify some characteristics of the fire’s evolution and the meteorological conditions in the region. Furthermore, two simulations were run with the Meso-NH model, which was configured with horizontal resolutions of 2.5 km and 5 km. The fire behavior, characterized by satellite observations, revealed periods with a sudden increase in active fire numbers. High temperatures and low relative humidity in the region characterized the fire weather conditions. The simulations confirmed the critical fire condition, showing the benefits of increasing the resolution of numerical models for the Pantanal region. The convection-resolving simulation at 2.5 km showed the repeated development of gust fronts in the late afternoon and early evening. This study highlights this dynamic that, coupled with intense surface wind gusts, was crucial for the intensification of the fire spread and unexpected behavior. This study is a first step toward better understanding fire dynamics in the Pantanal through atmospheric modeling, and it can support strategies for firefighting in the region.